After being fired, I became the light of medicine

Chapter 161 Simulator 2.0 comprehensive update!
"Welcome host to Medical Life Simulator 2.0."

After telling his office assistant that he needed to take a break, Zhang Yang locked the office door and entered the simulator.

As soon as he entered the simulator, Zhang Yang was stunned by the brand new scene.

Previously, the simulator was a light blue translucent light curtain, which displayed the nodes of the current plot that could be simulated.

But after this update, the entire simulator scene has been fully upgraded, and even the environment in which you are in has undergone tremendous changes!
The previous light blue translucent task panel is still there, but the entire simulator background has become a huge...

Biological laboratory?!

That's right!

Zhang Yang glanced around and saw various precision instruments shining in the neat laboratory under the bright lights.

There are cryo-electron microscopes that cost up to tens of millions of yuan each;
The third-generation gene sequencer that only top laboratories are equipped with;
There is also a Beckman ultra-high-speed centrifuge that can separate viral nucleic acids...

hiss.

Even though Qingshan Pharmaceutical's R&D center is already the best in the country, Zhang Yang was still surprised to see so many of the world's top precision equipment placed in one laboratory.

At this moment, the system's clear prompt sound rang.

"Dear host, the Medical Life Simulator 2.0 version upgrade is complete."

"The 'Story Simulator' in version 1.0 is still retained. You can select the simulated story from the light blue screen to enter the simulation. You can get the corresponding energy points and drug rewards as before."

Zhang Yang's gaze then fell on the light blue translucent light curtain.

Several previously completed "simulated plot copies" were displayed on the light screen and were lit up.

"The Tragedy of Blood" - "The Fate of a Generation" - "The Silent Killer".

He tried it, and found that the ones that were already lit up could still view the ending and even re-simulate.

but.

After the last simulation scenario "The Silent Killer", the next node still shows a small lock (not unlocked).

Zhang Yang didn't expect that there would be no new nodes after such a long time.

I can’t help but ask:

"Why hasn't it been unlocked yet?"

The system sounded:

"The first three plots are for beginners, and the subsequent simulation plots are for coherent plots!"

"The drug research and development capabilities of Qingshan Pharmaceutical, created by the host, are currently weak and have not met the conditions for opening a coherent plot. Once they are met, the system will automatically unlock them."

The drug development capability is weak.

The conditions for opening the subsequent plot have not been met...

Zhang Yang was a little surprised, but quickly shook his head.

Compared with the simulator, Tsingshan Pharmaceutical's R&D capabilities are indeed weak.

"The 1.0 version of the simulator did not update the new simulation nodes, so what features did the 2.0 version add?"

"Hello, dear host. The new feature added in version 2.0 is the biological research and development laboratory in front of you."

Zhang Yang was stunned and looked around the huge drug research and development laboratory in front of him.

"You mean I can run new drug simulations here?"

"That's right!"

The sound of the system is very stable.

"This simulator is designed to promote the development of human medicine. Currently, Qingshan Pharmaceutical, founded by the host, already has certain drug research and development capabilities."

"But in the long history of pharmaceutical research and development, the emergence of a new drug often requires several years or even more than ten years of research and development. Even after more than ten years, it is discovered that the research and development direction is on the wrong track, and ultimately the research ends in failure, wasting a lot of time."

“The 2.0 version of the drug development simulation laboratory can accelerate the development process, with the real time and laboratory simulation time being 1:10.”

"In layman's terms, in the real world, it only takes one month to obtain 10 months of data that would otherwise take 1 months to observe in the real world, thus greatly reducing R&D time."

Zhang Yang was surprised and immediately realized the power of the simulation laboratory.

You know, why does the research and development process of a new drug often take several years or even more than ten years?
Identifying the target and finding effective compounds is one of the factors, but more importantly,
After finding many effective compounds, the verification and screening stages are also extremely time-consuming.

For example, for the sAC cyclase activator that is being developed, even if an effective compound is discovered, it will take at least three to six months to test it, right?

If the effect is not good after waiting for three to six months, the drug ingredients will have to be modified, and then another three to six months of trial phase will be needed.

In addition, the same is true for clinical trials. Constant modification and verification all take time.

However, after being surprised, Zhang Yang suddenly had an idea and asked:
"The time acceleration in the simulation lab is 10 times. Can it be faster? For example, 1:20?"

The system was silent for two seconds, then replied:
"The time ratio of this simulation laboratory is fixed and cannot be modified. However, if the host wants to increase the research and development speed, he can pay energy points."

"Energy value?"

Zhang Yang seemed familiar.

"You mean the energy you gained from completing the 'simulated scenario'?"

"Yes, the host currently has 1000 energy points accumulated; the energy points can be used to accelerate drug research and development."

"This function is relatively complex, and it is recommended that the host directly try a new drug that has not yet been developed."

"Oh?"

Zhang Yang's eyes lit up and he became very interested. He immediately thought that the first project team of the Drug Research and Development Center was currently developing the "sAC cyclase activator" to enhance sperm activity.

Just enough to try it out.

“How do I try?”

As soon as he finished speaking, the light blue screen in front of Zhang Yang disappeared, and he appeared in the simulation laboratory.

After a moment, several data options appeared on the center console of the simulation laboratory.

Disease type,

Research direction:

Drug targets,

Compound molecular formula, animal experiment data...

"The host only needs to enter the data of new drugs that have not yet been successfully developed into the system, and the simulation laboratory will automatically calculate the current development progress of the drug, thereby creating a simulation process."

As a drug developer, Zhang Yang took a look at the data options on the center console and instantly understood them.

He immediately exited the simulator and quickly went to the Drug Research and Development Center to obtain the latest research and development data on "sAC cyclase activator" from the first project team.

The "sAC cyclase activator" project was launched just over a month ago, and the results are limited. The first project team is still looking for targets for the production of "sAC cyclase".

But that's just right.

Zhang Yang returned to the office again and entered the simulation laboratory.

Disease type: Asthenozoospermia.

Research direction: Improving "soluble adenylate cyclase sAC" in men.

Targets discovered: None.

Compound formula: None.

Zhang Yang filled in the data quickly, and about a minute later, a piece of text appeared on the central console of the simulation laboratory.

New drug development project: "sAC cyclase activity generator".

Current drug progress: 5%, the research and development direction has been discovered - sAC cyclase.

Next stage: target exploration (10%).

"Soluble adenylate cyclase sAC" is an important substance for maintaining the activity of male sperm and helps to improve the activity of male sperm.

At this stage, we need to find the target for the production of "sAC cyclase" in the male body, so that we can use drugs to make the male epididymis produce more "sAC cyclase" and improve sperm activity.

The host can explore the target autonomously in the simulation laboratory without paying any energy.

At the same time, you can also pay energy points to start automatic exploration.

"It costs 50 energy points to conduct target exploration. Once completed, the research and development progress will be increased to 10%, and the corresponding data simulation laboratory will be automatically replenished."

"May I ask if the host would like to proceed to the next stage of 'target exploration'?"

50 energy points.

Zhang Yang glanced at the 1000 energy points in the upper right corner and confirmed without hesitation:
"Conduct 'target exploration'."

"Payment successful, 'target exploration' in progress...Exploration failed, no effective target found."

What the hell!

Exploration failed?

Still fail?

Zhang Yang was stunned, it was unbelievable.

At this moment, the system voice sounded.

"The simulated drug laboratory uses deep scanning and data mining at the biomolecular level to lock targets in combination with the disease pathogenesis."

"The more complex the disease, the more unclear the pathogenesis, such as ALS and Parkinson's disease, the more data is needed to lock in the target, and the more difficult it is to discover."

Zhang Yang understood the system's explanation. If 50 energy points could 100% identify the target of a disease, it would be too easy.

However, he was still a little unhappy. 50 energy points were gone just like that?
"It is recommended that the host continue to try."

Zhang Yang shook his head helplessly, and then said:

"Continue with 'target exploration'."

"Target exploration is in progress..."

"Congratulations to the host for successfully discovering the target for 'sAC cyclase' generation. The current drug development progress is 10%."

“Next stage: lead compound screening (30%).”

This time, Zhang Yang was not in a hurry to advance the research and development progress, but took a look at the data on the console.

Sure enough, the drug target was changed from "none" to "HCO in the epididymis".

He then clicked on a more detailed information interface, and all the information about the target appeared in front of him. "HCO is the most important physiological activator of sAC. In the cell, HCO binds to the specific regulatory site β-C of sAC, triggering conformational changes in the sAC protein, thereby activating its catalytic activity and prompting it to convert ATP into cAMP..."

After reading it quickly, Zhang Yang was even more shocked. He could almost immediately tell that this target should be authentic!
After all, although these materials look very professional, in the eyes of professionals like Zhang Yang, they are just a complete instruction manual!
And the most shocking thing is!

According to his previous experience, if a drug development team wants to figure out the target information of sAC, it may take half a year if they are lucky, or a year if they are unlucky!
just now!

The simulation lab was completed in just a few minutes...

Thinking of this, his eyes fell on "next stage: lead compound screening (30%)".

The system sounded at the perfect time:
"After the target is identified, the simulation laboratory will conduct a 'target-compound' binding simulation in a huge database of compounds to preliminarily screen out a series of compounds that may interact with the target, which are the 'lead compounds'."

“At the same time, after the initial screening, there will be preliminary laboratory tests, using simple cell models to observe their effects on the target;
In this process, most compounds will be eliminated due to insufficient activity or poor selectivity, and only a few compounds that show certain potential can enter the next round of optimization. "

"This process is huge in terms of data. Each attempt requires 100 energy points. Once completed, the research and development progress will be increased to 30%."

“Similarly, all the information on ‘lead compounds’ screened out will be automatically completed.”

"Of course, host, you can try to find compounds in the simulation laboratory by yourself. Independent research and development does not require any energy value."

Independent research and development?

Zhang Yang couldn't help but smile bitterly. Who would switch back to manual transmission after trying automatic transmission?
The next second, his eyes fell directly on the required energy value.

100 points.

With the experience of exploring targets in the previous stage, he knew that there was a high probability of failure in this link.

And the probability should be quite high.

But seeing that there were still 900 energy points left, after a little thought, Zhang Yang decided to give it a try.

"Pay 100 energy points to conduct 'lead compound screening'."

"'Lead compound screening' is in progress..."

"Screening failed."

“Keep filtering.”

"Screening failed."

Two consecutive failures made Zhang Yang a little overwhelmed.

However, he also determined the operating mechanism of the simulated biological laboratory.

The simulation laboratory should determine the effect of the compound by observing the target-compound, just like the normal R&D team.

If you are lucky, you can successfully discover an effective compound in one try; if you are unlucky, you may fail dozens or even hundreds of times.

"try again!"

Fortunately, I finally succeeded on the third time.

"Congratulations to the host for successfully discovering multiple effective 'lead compounds'. The current drug development progress is 30%."

“Next stage: compound optimization and candidate drug identification (50%).”

Zhang Yang smiled bitterly again. This was really a series of links connected to each other, making it hard to stop.

The system prompts again:

"After discovering a variety of effective 'lead compounds', the core components of the new drug have basically been determined. The next step is to optimize the structure of the screened 'lead compounds'."

“This stage requires the use of chemical synthesis technology to change the molecular structure, crystal form and other small but critical changes of the compound, so as to enhance its binding and affinity to the target, improve its pharmacokinetic properties and reduce potential toxicity.”

“After multiple rounds of optimization and repeated testing, one or several most promising follow-up drugs will be identified from among the many optimized compounds.”

"This link does not require a large amount of data, but it is the most technically difficult. Each attempt requires 200 energy points. Once completed, the research and development progress will be increased to 50%."

"At the same time, it also means that the drug has basically completed the main research and development stage."

"May I ask if the host is conducting research and development?"

Zhang Yang did not make a choice immediately.

He had just checked that the research and development progress of the "sAC cyclase activity generator" had been completed by 30%, and the simulation laboratory had screened out nearly 25 effective "lead compounds".

He can download all the details.

He now has several options:

1. Provide the downloaded data to Tsingshan Pharmaceutical's new drug research and development center. There are 25 "lead compounds" and it is expected that the drug will be developed within a few years.

2. Carry out simulations in a simulation laboratory by yourself. The speed should be slightly faster than that of the R&D team, but you need to conduct simulation tests for a long time.

3. That is to continue to use 200 energy values ​​to allow the simulation laboratory to complete the experiment.

The three options can be said to be from slow to fast.

"Forget it. I still have 600 energy points. Let's give it a try."

“Once we have completed the ‘compound optimization and candidate drug identification’ stage, we should be able to develop our own products.”

"Perform 'Compound Optimization'."

"In progress of 'compound optimization'... optimization attempts failed."

Zhang Yang's heart skipped a beat. He still had 400 energy points left.

try again.

"Continue with 'Compound Optimization'."

"Congratulations to the host for successfully completing 'compound optimization and candidate drug identification'. The current drug development progress is 50%."

“Next stage: preclinical research (70%).”

“Once the candidate drug has been optimized and selected, it means that the main research and development phase of the drug has been completed.”

"However, before the drug is clinically marketed, it is necessary to conduct comprehensive 'pharmacokinetics', 'pharmacodynamics' and 'toxicology studies' on large animals, and to record parameters such as the duration and intensity of the drug effect after the drug binds to the target."

"The most important thing is to strictly record possible toxic reactions in preparation for submitting a clinical trial application."

"You need to pay 100 energy points to carry out this step. Once completed, the research and development progress will be increased to 70%, and all animal experiment data will be automatically completed."

After he finished speaking, Zhang Yang decisively refused.

He has completely understood that his energy value is the currency in the simulation laboratory!

Having energy value means that everything from "target exploration" to the final "animal experiment" can be completed quickly in the simulation laboratory.

Thinking of this,

Zhang Yang looked at the "sAC cyclase activity generator" which was already 50% finished.

Half an hour ago, the “sAC cyclase activity generator” had not even identified a drug target;

Half an hour later, the "sAC cyclase activity generator" had been completed and the "candidate drug was determined", and a large amount of information was available for download in the simulation laboratory.

This is so fast!
Of course, you need to have enough energy in advance!
Thinking of the energy value, Zhang Yang looked at the only 200 energy points left in his system.

correct……

It’s really cool, but how do I get the energy points?

The system replied:
“There are three ways to obtain energy:

1. Complete the "simulated plot" and get the corresponding energy value after reaching the valid ending;
2. Complete the research and development tasks provided by the "simulation laboratory", such as "lead compound screening" and "clinical trials" of a certain drug, and obtain corresponding energy value after completion;
3. Provide the "simulation laboratory" with complete drug data that is patented by the host. (Complete drugs are required.)
Note: The better the drug is, and the more difficult the disease is, the higher the points you can get. "

After reading to the end, Zhang Yang focused his attention on the second and third items.

At present, the "Simulation Plot" in the simulator 1.0 has not had any new nodes for a long time, and it is difficult to obtain energy values ​​from it regularly.

The second "simulation laboratory" research and development task... you can take a look at what the task is later.

The third thing Zhang Yang least expected was that such a powerful "simulation laboratory" would actually "collect" his own patented drug information?

You know, the simulator has provided me with drugs such as "ITG human myelopoietin" and "kidney toxin clearing dialysis needle", which are among the top drugs in the history of human medicine!
And now!
You actually think highly of the drugs you developed independently?

But gradually, he realized:

The "simulated drug laboratory" in front of us seems like a huge drug database, an extremely powerful computer?
You can pay energy points to let the "Simulation Laboratory" help you complete drug simulation at an unimaginable speed.

But if you want to gain energy points, you need to complete tasks and provide patented drug data.

Both sides help each other?

"It's interesting!"

Zhang Yang thought this method was pretty good. Just when he was about to complete 50%,

When the progress had reached the point where all the information on the "sAC cyclase activity generator" in the "animal experiment" was downloaded into the mind, the system voice sounded again.

"Dear host, I would like to introduce you to the 'Medical Simulator 2.0' version, the last function of the simulation laboratory."

"Looking back at the history of human medicine, there are countless drug formulas that cannot be marketed due to side effects and other reasons, and are eventually discarded in garbage dumps."

“The ‘Simulation Lab’ provides drug formulation optimization capabilities, which also require energy values.”

“Note: not all drug formulations can be optimized, only some drug formulations with optimization potential are available.”

After hearing the last word, Zhang Yang fell silent, and he thoroughly felt the powerful function of the "Simulation Laboratory".

The first thing that popped into his mind were the many drugs that were ultimately unable to be marketed around the world in recent years due to side effects.

"It seems that I have to pay more attention to the abandoned prescriptions of other pharmaceutical companies in the future..."

After expressing his feelings, Zhang Yang quit Medical Life Simulator 2.0.

This update is really a huge achievement.

Thinking about the "sAC cyclase activity generator" that had already completed "animal experiments" in his mind, Zhang Yang quickly came to Qingshan Pharmaceutical's drug research and development center.

Of course, he wouldn't be stupid enough to take out 50% of all the information at once.

After a while, Wei Tian appeared in the laboratory.

Zhang Yang said:
"Wei Tian, ​​I suddenly had an idea and I seem to have found a target for 'sAC cyclase'. Can you help me? I'll give it a try."

Wei Tian was a little surprised, but he had experienced Zhang Yang's talent many times.

"Good boss."

Two days later, there was a surprise sound from Qingshan Pharmaceutical's Drug Research and Development Center!
"Boss, you are amazing. It is hard to believe that you found the target of 'sAC cyclase' so quickly!"

"Well, I'm lucky. The next step is to start screening for 'lead compounds'. I happen to have some ideas about 'lead compounds'!"

　6K, I also know that there have been few updates recently, I will update more and more!
　　
　
(End of this chapter)