After being fired, I became the light of medicine

Chapter 160 The simulator finally "woke up"
"Is it related to male sperm activity?"

"You mean the sAC male contraceptive pill?"

Ren Xiaomin quickly realized that the only thing currently related to male sperm is the sAC male contraceptive pill!

But, this is the birth control pill!
Zhang Yang also saw Ren Xiaomin's confusion and explained:

"The full name of our 'sAC male contraceptive' is 'soluble adenylate cyclase sAC inhibitor'. Its essence is an inhibitor that inhibits the 'cyclase sAC' in the epididymis that provides activity for sperm, thereby achieving the purpose of contraception."

"So I was wondering, if we increase the level of 'cyclase sAC' in the male epididymis, can we increase sperm motility?"

"Of course, the global medical community currently does not have much research data on the specific causes and treatment plans for asthenozoospermia, so we can only explore step by step."

As he spoke, Zhang Yang handed a more detailed document to Ren Xiaomin and continued:

“Besides this, I would like to conduct drug research on teratozoospermia.”

"At present, the medical community believes that there are many reasons for the high rate of sperm deformity in men, and they are also very complicated, such as prostatitis, seminal vesiculitis, varicocele, and even smoking, drinking, staying up late and sitting for a long time can cause a high rate of deformity."

"These causes can be slightly improved by quitting smoking and drinking and improving your work and rest habits, but after reading a lot of research materials, I found that there is another common cause that has not been deeply studied in the medical community."

“It is well known that sperm production is regulated by a variety of hormones, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone.”

"These hormones are regulated by the hypothalamus-pituitary-gonad axis and control the rate and quality of sperm production. It can be said that they are the most important part of the sperm production process!
If any link in this regulatory system goes wrong, it will inevitably affect sperm production abnormalities and high deformity rates.
I even think that azoospermia is partly due to problems with the endocrine system that produces sperm.”

"However, there is no in-depth and reliable research in the medical community at home or abroad at present."

After hearing the end, Ren Xiaomin couldn't help but frown. Zhang Yang talked about too many knowledge points in one breath.

He slowly flipped through the information in his hands and gradually sorted out Zhang Yang's thoughts.

There are probably two reasons that lead to abnormal sperm and reduced activity in men: one is that there is an abnormality in the sperm production process;
Another type is that the sperm produced was originally fine, but when stored in the epididymis, its activity decreased due to various reasons and the sperm did not move.

Zhang Yang not only wants to increase sperm activity by increasing the sAC cyclase in the male epididymis, but also wants to solve the problem of abnormal sperm production from the source.

but!

This is a huge project. Just thinking about it makes me feel that the things involved are too complicated.

After thinking for a moment, he rubbed his temple and said:

"Zhang Yang, I have no objection to setting up a research project to study this drug that improves male sperm. After all, there are indeed more and more infertile men in the world now, and there will be more in the future;"

"From a business perspective, the future looks bright."

"But how can I put it? Just from your simple introduction, I can already feel the difficulty of the research and development. I'm afraid it won't produce results in a short period of time."

"We even have to be prepared for failure after investing a lot of resources."

Zhang Yang suddenly fell silent.

indeed.

Although infertility has only experienced explosive growth in the last decade, there are currently almost no drugs on the market to treat male sperm, and there are not even any pharmaceutical companies that have set up projects to develop related drugs.

On the one hand, although there are many infertile couples, there is always in vitro fertilization as a backup, and most couples can still get pregnant through in vitro fertilization.

On the other hand, as Ren Xiaomin said, the production and storage of male sperm involves too much and is too complicated.

To be honest, he had no idea.

After a moment, Zhang Yang took a deep breath and shook his head:

"Brother Ren, I understand your concerns, but just like what the medical celebrity who spread rumors about us on Weibo said, infertility has been a big deal in our traditional concept since ancient times."

"We now have sAC inhibitors as a breakthrough, and the market prospects are good. Even if there are difficulties in research and development, I think we can still give it a try."

Upon hearing this, Ren Xiaomin knew that Zhang Yang had made up his mind and stopped trying to persuade him. He just mentioned his own opinion at the end.

"Zhang Yang, I think it's too difficult to develop both asthenospermia and teratospermia or azoospermia together."

"It would be better to conduct separate research. For asthenospermia (activity), we should focus on sAC cyclase; for teratospermia, we should focus on endocrine hormones. If we develop the two projects separately as two drugs, I think the chances of success will be much higher."

Zhang Yang nodded:
"I think so too."

The communication between Zhang Yang and Ren Xiaomin ended quickly, and a drug for asthenospermia was determined based on the research idea of ​​"soluble adenylate cyclase sAC".

The other one studies male hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, and drugs for teratospermia and azoospermia are also determined simultaneously.

The two drugs were quickly assigned to Qingshan Pharmaceutical's drug research and development center.

The first drug, “sAC cyclase activator”, was naturally assigned to the first project team which had experience in the research and development of sAC cyclase.

However, the second drug involving hormones ran into a bit of trouble.

As we all know, the development of unknown drugs without clear targets is the most difficult.

Take the hepatitis B virus for example. Although the hepatitis B virus is relatively stubborn, the researchers and researchers still have a clear goal, ideas and direction.

For example, although kidney disease cannot be cured, researchers know that it is caused by damage to the glomeruli. The solution is to find ways to prevent damage to the glomeruli and protect them.

However, male sperm is produced in the testicles and is affected by a variety of male hormones, chromosome selection, and a production cycle of up to three months.
It can be said that any problem in any of these links may cause sperm deformity or even azoospermia.

In order to find out the specific cause and then pin it down to a specific target such as protein synthase, this requires a large number of repeated experiments and long-term observation and research.

If you think about it, you will know that the project is huge and it will take more than three to five years to produce results.

Therefore, after the project was announced, the leaders of several project teams showed little interest in it. In addition, each of them already had projects under development, so no one was willing to take over this hot potato.

Zhang Yang can understand it.

At this time, Wei Tian took the initiative to step forward and was willing to take over the research and development of this project.

Zhang Yang was quite pleased, but after thinking about it, he finally refused. He decided to lead the research and development himself. After all, as the head of the drug research and development center, Wei Tian was very busy at work, and he had other drug research and development projects on hand, so it was almost impossible for him to take care of it.

There is no need to rush for this hormone drug for treating teratozoospermia, and the current research and development focus is on "sAC cyclase activator".

In this case, it would be better for me to take charge of the research and development of this drug myself, and take it slowly over three to five years.

Thinking of this, Zhang Yang couldn't help but sigh.

The various drugs previously launched by Qingshan Pharmaceutical, such as "ITG Human Myelopoietin" and "Kidney Toxin Clearing Dialysis Needle", are not necessarily simpler than this endocrine drug for "teratozoospermia".

I didn’t feel anything at first, but now I think about it and realize the difficulty of research and development behind these drugs.

"Simulator, when can you start it up again?"

Just as Zhang Yang was sighing over the simulator, the article criticizing Tsingshan Pharmaceutical on Weibo began to ferment on the Internet slowly, just as Ren Xiaomin had said.

Many netizens were convinced by the views in the article and agreed that Qingshan Pharmaceutical did not need to develop any male contraceptives. It would be better to invest more energy in developing infertility drugs.

It has to be said that this situation would never happen to any domestic pharmaceutical company!
Are you kidding? It’s an independent biopharmaceutical company’s own business what kind of drugs it develops. What does it have to do with netizens?
But this is Qingshan Pharmaceutical!
Tsingshan Pharmaceutical's reputation and influence in China are simply too great.

“ITG human myelopoietin” that cured 400 million patients with aplastic anemia;
Afovir, which cured 1.2 million hepatitis B patients and troubled a generation of people;
As well as the chronic kidney disease drug "Kidney Toxin Clearing Dialysis Replacement Injection" which has an audience of 1 million people!
It can be said,
Every drug produced by Qingshan Pharmaceutical has brought rebirth and hope to countless patients!

But at the same time, it also makes patients with other diseases have unparalleled expectations for Qingshan Pharmaceutical.

Many patients have left messages before hoping that Tsingshan Pharmaceutical could develop drugs to cure liver cancer and lung cancer, but after all, they are only a few and scattered.

But this time, there are more and more such voices under the articles on Weibo.

Besides, a big tree attracts the wind.

The strong rise of Tsingshan Pharmaceutical in recent days has made the situation of many pharmaceutical companies increasingly difficult, and many people hope that Tsingshan Pharmaceutical will fall into a public opinion crisis.

With the combination of these two factors, there is more and more public opinion against Tsingshan Pharmaceutical on the Internet, and public opinion on Tsingshan Pharmaceutical is gradually falling into a passive position.

Zhang Yang saw it, frowned, and finally decided to ignore it.

Although Qingshan Pharmaceutical's R&D center has already initiated the research and development of "sAC cyclase activator", it will take more than one or two days to produce results, and it is still unclear whether there will be any results in the end.

Moreover.

As soon as there is a little public opinion on the Internet, I have to respond to the development of a new drug. If netizens make even more excessive demands, do I have to agree to all of them?
impossible!
There is no way Tsingshan Pharmaceutical will accept being coerced by the Internet.

But what Zhang Yang didn't expect was that his silence not only failed to cool down the online public opinion, but instead intensified it.

In Shanghai, in an exquisite room, Weibo celebrity Liu Zhiyuan was smiling as he read the various comments hoping that Qingshan Pharmaceutical would develop infertility drugs.

Half a month ago, he received a new task from his MCN company, hoping that he could criticize and discredit Qingshan Pharmaceutical's contraceptive pills from the perspective of a medical doctor, thereby affecting its sales.

At the same time, we also hope that he can try his best to create some influence on public opinion for Qingshan Pharmaceutical.

After much deliberation, he finally came up with a perfect idea, which was to link Qingshan Pharmaceutical's "sAC male contraceptive" with infertility drugs, thereby embroiling Qingshan Pharmaceutical in a whirlpool of public opinion.

The results seem good so far.

Not only did he feel good about it, but even the financial sponsor behind him was quite surprised by the good results. Just ten days later, Liu Zhiyuan received another notification from his financial sponsor.

This time, they did not continue to ask Liu Zhiyuan to attack Qingshan Pharmaceutical's "sAC male contraceptive pills", but asked...

"Continue to incite netizens online to hope that Qingshan Pharmaceutical will develop infertility drugs, causing it to be caught in a whirlpool of public opinion and unable to back down."

As soon as the new task was issued, Liu Zhiyuan quickly understood the thoughts of the financial backer behind the scenes.

This person is determined to lead Qingshan Pharmaceutical into a trap!

He even guessed that the main financier behind the scenes was either a contraceptive manufacturer or a condom manufacturer. In any case, it must be in direct conflict with Qingshan Pharmaceutical's "sAC male contraceptive".

From the perspective of the domestic market, the domestic contraceptive market is very small, and it is almost impossible to spend so much effort targeting Tsingshan Pharmaceutical.

On the contrary, China is the world's largest condom market!

So……

He almost guessed who the financial backer was.

However, he doesn't care. As long as he is paid, he is willing to act as a water army.

quickly,

Driven by Liu Zhiyuan and more internet trolls, there was more and more public opinion about Tsingshan Pharmaceutical on the Internet. Some reporters even called the headquarters of Tsingshan Pharmaceutical to inquire whether there were any plans to develop "infertility drugs".

Zhang Yang has been devoted to the research and development of drugs for "teratozoospermia" for some time. He originally didn't want to pay attention to it, but gradually, some staff members began to respond that it was almost impossible to promote "sAC male contraceptive" on the Internet!

Almost all the promotional screens have messages like "Don't bother with contraceptives, instead develop infertility drugs!"

This kind of comments are obviously from a cyber army, but they do reduce the effectiveness of the promotion of Qingshan Pharmaceutical's "sAC male contraceptive".

"sAC male contraceptive pill" seems to be bundled with infertility drugs.

Zhang Yang is not very concerned about the sales of "sAC male contraceptive pills". To be honest, the domestic market is just an initial market, and its sales are far less than those in the European and American markets!
He was just very upset about being controlled by the Internet!

Moreover, when things got to this point, big Vs and internet trolls have all appeared, which clearly shows that there is someone behind the scenes!
This is someone clearly trying to discredit the "sAC male contraceptive pill"!
You know, the "sAC male contraceptive" has just been launched on the market, and with the publicity from Mr. Huang and Duke at its peak, it's a good time to expand the market!
If this happens, all the rhythm will be broken!
It will not be easy to develop the market again and gain greater popularity in the future!

But what can he do?
It was announced that Tsingshan Pharmaceutical has begun to develop infertility drugs, and then it was followed by the rhythm?
This is not what he wants!
The best way, naturally, is to bring out the results of infertility drugs now and use them to slap others in the face, so don’t talk nonsense!
but!

The two drugs have just been launched and there will be no results for another three to five years!

Zhang Yang shook his head.
But at this moment, a clear voice suddenly sounded in my mind:

"Medical Simulator 2.0 version update completed, please enter and check as soon as possible!"

(End of this chapter)