After being fired, I became the light of medicine

Chapter 163 Durex, it's time to fight back! (Subscribe)
Doctor Feng Yan paused for a moment and said:

"The cost of the first-generation test-tube baby is about 3 yuan, and the second-generation test-tube baby you are going to do is about 5 yuan."

"However, there is one thing I must explain to you in advance. IVF is not always successful in one try. On the contrary, based on our previous clinical experience, the chances of success the first time are very low."

"Most couples succeed after 3-4 attempts, and some even get pregnant after 7-8 attempts. For serious cases like yours, you should be mentally prepared."

After saying this, Feng Yan looked at Xu Min and Liu Qiang's expressions changing from anxious to shocked, and then she added:

"This is how things work in medicine. IVF can only be said to be artificial intervention to force sperm and eggs to form a fertilized egg, and then transplant the fertilized embryo into the uterus."

"But the human body has a strict and sophisticated screening mechanism. After we think that good embryos are transplanted into the uterus, they often have developmental abnormalities and cannot implant, which eventually causes the embryo to stop developing and lead to miscarriage."

"So, once this happens, we have to do the IVF again... until the embryo develops successfully in the uterus."

Dr. Feng Yan’s explanation is easy to understand, but...

Xu Min bit her lip and looked at her husband Liu Qiang.

If what Dr. Feng Yan said is true, and the IVF fails 3-4 times or even more, then it would cost at least 20 yuan.

At least 20!
It is a huge sum of money for an ordinary family like theirs!

"What about reimbursement, doctor? How much can medical insurance reimburse?"

Xu Min asked with his last hope.

Feng Yan shook her head:
"Medical insurance reimbursement... Currently, most outpatient clinics in reproductive technology departments are reimbursed by local policies. The policies in each region are different. We in Chengdu can reimburse some, but not much!"

"For example, the cost of your second-generation test tube is 50,000 yuan, and about 10,000 yuan can be reimbursed; and even the 10,000 yuan is a policy that was just introduced this year. In the past, it was almost not reimbursed."

After he finished speaking, Liu Qiang and Xu Min fell silent. This means that each test tube costs at least 4 yuan.

One IVF test costs nearly half a year's salary.

half an hour.

Xu Min's eyes flashed with determination, and she looked at the doctor Feng Yan:
"Doctor, we will listen to you and start IVF!"

"it is good!"

Feng Yan nodded, then looked at the two of them:

"Now that you've made the decision, sign the consent form."

"Bring your marriage certificate and ID cards tomorrow. We need to give you a comprehensive physical examination first, and then you need to take medicine, take progesterone, and do other preliminary preparations."

"With luck, I can start trying IVF after my period ends next month."

"Then I'll trouble you, doctor."

After two years of trying to get pregnant naturally without success, and after taking medication and increasing exercise, the sperm quality was still seriously abnormal.
Liu Qiang and Xu Min finally decided to start in vitro fertilization immediately.

of course,

It is not as simple as it sounds before doing IVF. Both men and women need to undergo a comprehensive examination, especially women who need to inject a lot of injections to artificially regulate the hormone levels in their bodies...

Xu Min began to cooperate with the doctor to prepare for in vitro fertilization.

the other side.

The sAC cyclase project of Qingshan Pharmaceutical R&D Center is also progressing in an orderly manner.

With the help of Zhang Yang, the "sAC cyclase project" completed the screening of "lead compounds" in just 2 months, with incredibly high efficiency!
The next step is to optimize the internal molecular structure of the compound and start animal experiments.

Once animal testing is complete, clinical trials can begin!

In addition to the smooth progress of the "sAC cyclase" project to enhance sperm activity, Zhang Yang also insists on running the "severe teratozoospermia" project to explore targets in the simulation laboratory every day.

quickly,

Ten days, half a month, a month.

Just as Zhang Yang watched his energy value decrease every day, on the 45th day, after 450 hours, or 4500 hours,

The simulation laboratory finally discovered an important target through a large amount of experimental data!

Sperm Morphology Regulator Protein (SMRP);
Abbreviation: SMRP.

As we all know, the process of male sperm production is mainly completed in the testicles, and the production process involves the influence of male hormones such as luteinizing hormone (LH) and testosterone.

Zhang Yang initially thought that it was the hormone maximization that affected the morphology of sperm during male sperm production, but after a large number of experiments and data screening, he found that the relevant hormone levels in the bodies of many men/male animals with severe teratospermia were actually normal.

In other words, the hormone levels in men's bodies are not necessarily positively correlated with sperm abnormalities.

He then changed the direction of his research.

As we all know, sperm is a complex cell structure composed of multiple substances.

The most important substances are proteins and nucleic acids.

Nucleic acid can be understood as the genetic material that carries paternal DNA, which includes various important genetic information.

This genetic information is combined with the genetic information of the egg after fertilization to determine the genetic characteristics of the offspring, such as appearance, physical characteristics, susceptibility to certain diseases, etc.

Protein is an important substance for maintaining the structure of sperm, and it also plays an important role in protecting DNA!
It was when Zhang Yang was analyzing a substance called "structural protein" in proteins that he finally discovered the target named "sperm morphology regulatory protein" (SMRP).

SMRP is also a protein that is involved in the formation and development of sperm throughout the sperm production process.

It can bind to specific gene promoter regions and regulate the expression of a series of genes related to sperm morphology.

In simple terms, although it is just a protein, it is the brain that produces every sperm and controls the shape of every sperm!
The results of the experiment also confirmed Zhang Yang's judgment.

Once the expression level of SMRP protein decreases, it will lead to insufficient synthesis of some key structural proteins, resulting in abnormal morphology of the sperm head, such as a head that is too large, too small, or irregular in shape.

On the other hand, if the activity of SMRP is disturbed, it may affect the assembly of the sperm tail and the function of dynein, leading to sperm tail deformities, such as bending, short tails, multiple tails, etc. In addition, environmental factors, genetic mutations or certain disease states may affect the stability and function of SMRP, causing it to lose its normal regulatory function, thereby causing teratozoospermia.

In other words, the target that causes teratozoospermia or even azoospermia has been found!

The next step is to find the right and effective compound!
Zhang Yang did not hesitate and continued to search for the "lead compound" in the "simulation laboratory".

Simultaneously,

He immediately extracted the target data obtained in the "simulation laboratory" over a period of 450 hours, and then quickly established the ninth project team under his direct charge, and began preparing to complete the realistic reproduction of the "SMRP" target!
But just as Zhang Yang was excitedly transferring the "SMRP" target results to the real world, Ren Xiaomin suddenly came to the office again.

This time, Ren Xiaomin's mood was obviously much better than the last time he reported to Weibo celebrity Liu Zhiyuan.

As soon as he entered the door, he said cheerfully:
"Zhang Yang, I heard that the 'sAC cyclase' that our R&D center has developed for treating sperm activity has made rapid progress recently. They have begun the final molecular structure adjustment. The next step is animal testing!
Isn’t this progress too fast? "

Zhang Yang put down the documents in his hand and laughed.

What Brother Ren didn’t know was that there is an even more amazing drug on the way, a drug for treating teratozoospermia and even azoospermia.

“It wasn’t too fast. After all, we already had a foundation in sAC cyclase, and we found the corresponding compound very quickly after discovering the target.”

"You'll understand it soon enough."

"Too……"

Ren Xiaomin didn't say more about this matter, as this was not the main purpose of his visit today.

After a moment, he talked about something else.

"Zhang Yang, do you still remember Liu Zhiyuan, the medical bigwig who previously posted an article on Weibo to slander and attack us?"

"The two articles he published before did cause us a lot of public pressure, especially the one that said 'Qingshan Pharmaceutical should not develop contraceptives, but infertility products', which made it impossible for us to promote the 'sAC male contraceptive pill' for a while, which put us in a passive position."

"However, yesterday the domestic sales figures for the last two months of 'sAC male contraceptive pills' were released, and the sales are pretty good, far better than we expected."

Oh?
Hearing this, Zhang Yang was a little surprised, and then he laughed:

"It seems that the majority of people are normal people, and they are not led by the influencers and internet trolls."

"That's right. Just because we are Qingshan Pharmaceutical, does that mean we should develop infertility drugs? So it's wrong for us to develop male contraceptives? What kind of bandit logic is that?"

Ren Xiaomin smiled bitterly and then poured half a glass of water from the water dispenser.

He moistened his throat and said:

"In addition, I have discovered an important clue these days. The medical big V Liu Zhiyuan was indeed instructed by someone."

"His should be an overseas condom company."

"Condom company?!"

Zhang Yang was stunned and his expression instantly became serious.

"Do you know which one specifically? Durex? Okamoto? Or any other?"

Ren Xiaomin's expression also turned serious.

"I guess it's Durex, but I don't have absolute evidence yet."

Durex.

Zhang Yang stood up from his chair and fell into deep thought. At this moment, Ren Xiaomin continued:

"According to our retail sales data for the two male contraceptive pills, our main customers are not only middle-aged men aged 35-45, but also unmarried young people under 25 years old."

"Most of these young people used to use condoms for contraception, but now some of them choose us... And coincidentally, these unmarried young people under the age of 25 are also Durex's core user group."

"In other words, the emergence of our male contraceptive pills has robbed them of their core customers."

"No wonder……"

Zhang Yang reacted immediately.

If it was Durex then everything would make sense.

sAC male contraceptive is Durex's direct competitor, so Durex has a complete motive to find ways to attack Tsingshan Pharmaceutical's male contraceptive, even at the cost of hiring internet trolls.

At this time:
"Zhang Yang, they previously invited a big V to criticize us for developing infertility drugs. Now you see, our 'sAC cyclase' for treating asthenospermia is about to begin animal experiments. Should we make this news public?"

"Didn't they lead the way by saying, 'We should develop a fertility drug?' And we actually have some results!"

A second later, Zhang Yang nodded:

"That's right, now the heat of this matter has cooled down, let's heat it up!"

"Send a press release to report the latest progress of 'sAC cyclase' and its possible use in treating weak sperm in men!"

"Tell them that we at Qingshan Pharmaceutical can not only develop male contraceptives, we can also develop infertility drugs."

"I want to see what other reasons they have to criticize us!"

A gleam of brilliance flashed in Ren Xiaomin's eyes. It's time to fight back!

Two hours later, the news that Tsingshan Pharmaceutical had made a breakthrough in the treatment of "male asthenospermia" and was about to conduct animal experiments spread throughout the entire Internet.

Originally about Qingshan Pharmaceutical's male contraceptive pills;

A topic that had been quiet for a few days suddenly became popular again!

A heated discussion immediately broke out on the Internet.

(End of this chapter)