1995, Starting as a Criminal Investigation Expert

Leaving Bao Yaning dumbfounded, Li Shu took the prepared materials and went directly to find Ni Jingsong.

Then we went straight to the Institute of Genetics and Developmental Biology with him.

Although it's called the Institute of Genetics and Developmental Biology, it's actually two institutes: the Institute of Genetics and the Institute of Developmental Biology.

The two institutes don't even share the same office location.

The institute we were going to was the Institute of Genetics. The Institute of Developmental Biology mainly studies animal embryos, cell differentiation, and transgenics, but does not conduct research on human NA typing.

In fact, even genetic research institutes don't seriously conduct DNA typing research in the field of forensics.

His main job is to study plants, primarily focusing on cellular genetics and chromosome engineering in crops such as wheat, rice, and soybeans.

The goal was to solve the major problem of feeding the entire nation, and the study of genetics was only incidentally taken as an opportunity.

inside the car.

Ni Jingsong flipped through the feasibility report written by Li Shu, becoming increasingly alarmed with each reading.

"Li Shu, you're... about to do something big."

Ni Jingsong put down the documents, her mind still unsettled.

This is an outline-style report that comprehensively explains the importance and role of NA typing technology.

But Ni Jingsong didn't look at this; he knew in his heart whether the T-fractal was important or not.

It's mainly below.

Li Shu listed nine research directions, with the ultimate goal of completing the 13-site fluorescence t-complex amplification and capillary electrophoresis technique.

To be honest, Ni Jingsong wouldn't even dare to think about a problem of this magnitude.

Li Shu, on the other hand, is like a newborn calf unafraid of tigers; not only does he dare to think, but it seems he also intends to do it.

Of course, Li Shu has already solved many problems in the area of ​​Na typing, and now he has even made magnetic beads to solve the problem of automated Na extraction equipment.

In theory, he should be qualified to do this research, but Ni Jingsong still thinks it's an exaggeration.

They're young people after all, so daring to dream!

He looked Li Shu up and down and felt a pang of emotion. Logically speaking, he was also quite young, only 47, but in front of Li Shu, he felt old.

Li Shu asked, "Director Ni, this is just a preliminary idea. What do you think?"

I've only written an outline and planned the research direction; there's still a lot of specific content to be covered.

Li Shu made a preliminary estimate and found that, not counting equipment such as capillary electrophoresis apparatus, there are probably dozens of technical problems to be solved just in terms of reagents alone.

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Even if they knew the standard answer and it could guide the research direction, a research project of this scale was not something that Ni Jingsong and his team could handle.

"What can I say?"

Ni Jingsong chuckled self-deprecatingly, thinking to himself, "These are things you've brought up. I wouldn't even normally think about them. What thoughts could I possibly have about them?"

"By the way, why are there 13 loci?"

Ni Jingsong pointed to the first item and asked a question.

The first item is the screening of 13 sites and the design of primer systems.

Ni Jingsong continued, "I did see a report that said in April of this year, Facebook was preparing to screen loci for T-sites in preparation for its establishment. The report mentioned that they selected 17 loci. So why did we only do 13?"

13 and 17 are several orders of magnitude different.

Li Shu was actually trying to figure out the problem, but according to the data, the first generation of standardized fluorescent T-segmentation technology used 13 points.

It seems to involve factors such as site heterozygosity and linkage, which Li Shu is gradually trying to understand.

But since the standard answer is 13, let's just copy it first.

After thinking for a moment, Li Shudao said, "I think 13 is my lucky number."

"what?"

Ni Jingsong's eyes widened. "Doing research? Is this some kind of childish game?"

Li Shu laughed and said, "Just kidding. I mainly think the scale is sufficient. 13 points can reach 10 to the power of negative 14, which is in the tens of trillions, far exceeding the global population."

"You also need to factor in the degradation of the sample, the richness of the ethnic group, and the close kinship. 13 should be a more appropriate number."

Ni Jingsong breathed a sigh of relief, almost thinking that Li Shu had just randomly chosen a lucky number.

This statement is sufficient proof that Li Shu's report was indeed the result of careful consideration and research.

Holding the report for a moment, Ni Jingsong asked, "So, are we going back to the Institute of Genetics this time?"

Li Shudao said, "Take a look around. After all, it's such a big project. If you can handle it, then we can head back home now."

Ni Jingsong quickly shook his head: "No, I can't handle that."

This isn't like making magnetic beads, where you combine existing technical solutions.

Even so, Bao Yaning lost a lot of hair and had terrible headaches during that period.

With so many research areas involved, even if I were to divide myself into ten pieces, I still wouldn't be able to figure it all out.

But Ni Jingsong immediately frowned and said, "Li Shu, there's a problem. If we go to the Institute of Genetics for this kind of research, I feel like they won't be able to handle it either."

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"Firstly, their research direction is different from ours."

Humans are engaged in basic scientific research, focusing on human molecular genetics.

On the other hand, the second institute focuses on the identification of identity in the field of forensic medicine.

The research samples are all different.

They recruited volunteers legitimately, and the blood drawn was from clean, human bodies.

However, in the field of forensic medicine, the blood at the scene has been contaminated countless times. The research direction is to make a determination of identity under interference.

"Also, if we're really talking about fractal technology, I'm not bragging, but they might not actually be as good as us."

A proud and self-satisfied expression inevitably appeared on Ni Jingsong's face.

Because Li Shu is truly the best in the country when it comes to na extracting.

He then explained his concerns in detail.

In terms of gene research and theory, the gap between China and foreign countries is not very large, and in some areas, China has even reached the first-class level.

However, when it comes to theoretical research alone, the gap is huge when it comes to specific technologies.

The equipment, reagents, tools, and technology were all imported from abroad.

Every research institute in China is the same; they buy foreign equipment and reagents, without any distinction between high and low quality.

Therefore, in this horizontal comparison, the second institute is actually stronger in fractal technology.

In particular, the automatic extraction equipment that we are about to develop will be the first in the country and a world leader.

In that case, going to the Institute of Genetics and cooperating with them would not be of much help or significance, in Ni Jingsong's view.

In fact, Li Shu had already considered the point that Ni Jingsong mentioned.

After searching for relevant information, I found that the Institute of Genetics is not a domestic research institution specializing in NA typing, human chromosomes, and medical genetics.

For example, the Yunnan Provincial Institute of Zoology is a leading institution for chromosome marker work.

The old research team was working on it at the Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences.

Then there's the medical field.

The Academy of Sciences has a Institute of Medicine, and Matsuura is also quite impressive, with a Cell Biology Institute.

There are also schools.

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Sun Yat-sen University of Medical Sciences in Guangdong and Changning Medical University are both quite prestigious.

Furthermore, within the department itself, the Liaoning Provincial Criminal Police Academy also conducts in-depth research in the field of forensic medicine.

As Ni Jingsong said, in terms of simple typing and extraction technology, the two institutes are indeed the strongest in the country.

Li Shudao said, "Director, I think it's still different. After all, this is the Institute of Genetics."

The Institute of Genetics, Chinese Academy of Sciences.

To conduct such large-scale research in the future, we need to collaborate with others and mobilize resources, which requires finding a heavyweight research institution.

As the saying goes, it's good to take shelter under a big tree, and it's also true that finding the right person can make things twice as easy.

After much deliberation, Li Shu felt that the Institute of Genetics was the most suitable option.

When Li Shu shared his thoughts, Ni Jingsong suddenly understood and looked at Li Shu with surprise, saying, "You're quite shrewd."

Having a sharp mind is a good thing.

Ni Jingsong always felt that he was too honest and only thought about doing research.

After thinking for a moment, Ni Jingsong said, "If that's the case, wouldn't it be more suitable to approach the Human Genome Project?"

In 93, two academicians spearheaded the project, with funding from the National Natural Science Foundation of China, to initiate the domestic human genome sequencing project.

"Didn't you write in your report that you were going to conduct a nationwide screening of 50,000 ethnic groups across all ethnic groups?"

Li Shu shook his head decisively: "They're not good enough."

What they did was essentially using readily available foreign kitchen equipment to cook domestic dishes.

What Li Shu wanted to do was to build a kitchen that was more advanced than those abroad, which was a completely different concept.

Ni Jingsong understood and said, "If that's the case, then no one in China is doing this kind of research."

They used readily available foreign technologies for research.

Then the genetics institute is naturally out of the question.

Li Shudao said, "Director Ni, we've only just begun, it's not even close to being done yet. Let's take it slow and not try to achieve everything at once."

Ni Jingsong's eyes widened slightly.

Can you achieve everything in one go?

In his view, Li Shucai truly wanted to achieve the goal in one step, and not even to catch up with foreign countries, but to surpass them.

While other countries are still struggling with reagent kits for 9 sites, Li Shu is already working on 13 sites.

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As they were talking, the car arrived at its destination.

In the northern suburbs, there is a nine-story building, which was originally planned to be used as an experimental building for a university of science and technology.

As a result, the University of Science and Technology did not settle in Anjing, but was assigned to the Institute of Genetics.

It's not just their institute; the Institute of Geography of the Chinese Academy of Sciences is also here, as is a Comprehensive Scientific Expedition Committee—three units in one building.

The courtyard directly opposite the building is the experimental field of the Institute of Genetics, where all sorts of crops are grown, and there are even greenhouses.

The "Old Zhao" that Ni Jingsong mentioned earlier is Zhao Anmin, the head of the department in the Institute of Genetics who is in charge of human genetics research.

He is very familiar with Ni Jingsong, and they have a good relationship.

He was over forty years old and had been engaged in research for many years. He had much less hair than Ni Jingsong, thick lips, and a very amiable appearance. Upon hearing the name Li Shu, his eyes lit up immediately.

Grasping Li Shu's hand tightly, he said excitedly, "Li Shu, I've heard so much about you!"

Although they couldn't use the NA purification technology developed by Li Shu, since they were drawing clean blood, the techniques and methods were common and useful.

Not to mention, he also learned from Ni Jingsong that Li Shu was researching an automated naphthalene extraction device.

Once this technology is developed, it will help research institutes across the country bypass the limitations of silica column reagent kits.

Everyone in the country who is engaged in genetic research should remember Li Shu's kindness.

He enthusiastically brewed tea, inquired about the research progress, and said apologetically, "Li Shu, don't forget us when you successfully develop this, we're all waiting for you."

The entire department has twenty or thirty people, with a bunch of graduate students working like beasts of burden, but it still isn't enough.

"OK."

Li Shu smiled and nodded, exchanged a few more pleasantries, and then got down to business, talking about his plans.

As Zhao Anmin flipped through Li Shu's report, his expression was similar to Ni Jingsong's when he first saw it; the more he read, the more alarmed he became.

After a long while, when Li Shu finished speaking, he had also finished reading.

He put down the report and froze, arms crossed, lost in thought.

After a long while, Ni Jingsong couldn't help but ask, "Old Zhao, say something! If this doesn't work, we'll go find your Chief Li."

Zhao Anmin then spoke, shaking his head and saying, "No, it's no use going to Officer Li. To be honest, we can't do this, and Li Shu, you don't need to run around anymore."

"Let me put it this way, no one in the whole country can do it. Even if you bring all the relevant research institutes in the country together and they all study it together, you still can't do it."

Li Shu was taken aback.

Ni Jingsong was also stunned, and frowned, saying, "Old Zhao, don't discourage yourself."

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Zhao Anmin shook his head and said, "I'm not trying to discourage us, but it's a fact. They started researching reagents and equipment abroad in the 1970s and 80s, more than 20 years ahead of us."

"Moreover, it wasn't developed by one country. It was the result of the combined efforts of so many countries, top research institutes, and commercial companies around the world that gradually achieved this level of research."

"If you want to complete the entire technology chain and surpass others, it's like taking on the whole world by yourself."

"Then tell me, how can you possibly do that?"

After spending more than an hour at the Institute of Genetics, Li Shu and his companion went downstairs to leave.

"That old Zhao is infuriating, and such a coward! Li Shu, if you can't find someone else, go to the Medical Research Institute. I know people there," Ni Jingsong said indignantly.

Li Shu shook his head.

What Zhao Anmin said was actually correct; what he was doing now was taking on the whole world single-handedly.

The key issue is that Li Shu can't directly reveal that he has obtained the standard answer, otherwise he won't be able to convince Zhao Anmin that he can succeed by following him in research.

Moreover, as he mentioned, there is a very real problem: his human genetics department has limited funding, and even the entire institute of genetics has limited funding.

So money is also a big problem.

The cost of screening groups of 50,000 or more is enormous.

Seeing Li Shu remain silent, Ni Jingsong comforted him, "Li Shu, don't think too much about it. Let's take it slow. We've given them a chance, but they didn't know how to seize it. Once we figure it out, they'll regret it."

Li Shu didn't think much of it. After hesitating for a moment, he suddenly said, "Director Ni, what if we handled this ourselves?"

Ultimately, it requires a strong governing body that believes in its ability to handle the research and development and is willing to invest money and manpower.

Since we can't rely on other units, we might as well do it ourselves.

Anyway, within the ministry, one's word still carries weight.

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