1995, Starting as a Criminal Investigation Expert

When Li Shu met Sun Bomin at the Institute of Chemistry last time, he felt that Sun Bomin was quite a character.

Sure enough, a person came strolling over with a water cup in hand, without notifying Liu Yaoqing.

"As for tea, let me try what kind of tea your fingerprint department drinks. I like to wander around and drink tea to see which unit has the best tea."

He sat down with an air of authority, tapped the table, and ordered tea to be made.

Bao Yun hurriedly went to make tea.

"Academician Sun, this is some Maojian tea my father-in-law gave me. Please try it." Bao Yun brought over the brewed tea.

Sun Bomin blew away the foam, took a small sip, and said after tasting it, "It's so-so."

They didn't give me any face at all.

But as an academician, he has truly reached the point where he doesn't need to give face to anyone.

"Li Shu".

Seeing that Li Shu was still standing, Sun Bomin asked, "What kind of tea do you want to drink?"

Li Shu was wondering why Liu Yaoqing hadn't arrived yet when he immediately said, "Academician Sun, I'm just having a casual drink."

I occasionally drink tea, which I can easily buy for a few yuan per kilogram on the street.

Li Shu preferred to drink a little sweet water.

Unexpectedly, Sun Bomin put down his teacup and was about to drink Li Shu's.

Bao Yunchong and Li Shu exchanged a glance, giving each other an inquiring look: What does this mean? Are you here to interrogate me?

Li Shu didn't know.

I reckon it was because I asked Bao Yaning to inquire at the Institute of Chemistry last week that Sun Bomin found out.

As soon as I walked in, I asked myself if I had any new ideas.

"Then I'll brew it for you." Li Shu hurriedly went back to his office, grabbed some tea leaves, and brewed the tea.

Taking the teacup, Sun Bomin also tasted it and nodded, saying, "Not bad, good tea. I like drinking this kind of tea."

Bao Yun smiled wryly, thinking to himself that what he was drinking wasn't tea, but rather a person.

Sun Bomin, holding a teacup, got up and walked towards Li Shu's office. Bao Yun and the others followed, but he turned around and stopped them: "What are you doing following us?"

As he spoke, he closed the door behind him.

Everyone stared at each other in disbelief, and Zhang Yanbei muttered softly, "She's got quite a temper."

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Bao Yun glared at him.

Wang Ze'an patted him on the shoulder and said, "Kid, when you become an academician, you can be as temperamental as you want."

Inside the office.

Sun Bomin sat down directly in Li Shu's chair, wiggled his hips, and nodded, saying, "Not bad, quite comfortable."

Then he asked Li Shu what books he had been reading lately.

He picked up a thick, gold-embossed book from the table, glanced at it, and said, "Monoclonal Antibodies in Biology and Biotechnology, Cambridge Edition."

It's the original English version.

"Wait, you're actually planning to do genetic biology research?"

I put down the book and glanced at the bookshelf behind me. It was a mess, with all sorts of books, but at a glance, there were indeed quite a few books on genetics and biology.

Li Shu pulled up a chair, sat down, and nodded, saying, "That's right. After all, we develop magnetic beads specifically for na typing."

Upon hearing the mention of magnetic beads, Sun Bomin immediately sat up straight and said, "I heard you're going to make decorative items for magnetic beads?"

Li Shu thought to himself that they had indeed come by following the scent.

Of course, since he had already planned to find Sun Bomin, Li Shu immediately picked up an unfinished feasibility report from the table.

"I don't read this stuff, there are too many words, just tell me directly."

Li Shu nodded and had no choice but to explain his thoughts.

In other words, a chemical modifier targeting drugs is added to the magnetic beads to accurately capture drugs in sewage.

The system's documentation actually introduces many specific types of modifiers.

Some are specifically targeted at opioids, while others are specifically targeted at methamphetamine.

Considering technical feasibility and convenience, and given that opioids are still the mainstream, Li Shu chose benzenesulfonic acid group.

This is a commonly used packing material for traditional β-extraction columns, and the technology is relatively mature.

Sun Bomin frowned slightly: "Benzenesulfonic acid group, positively charged alkali molecule? You...you're testing for drugs?"

Extraction columns using benzenesulfonic acid groups as packing material have existed since the 1980s. As Sun Bomin said, they capture positively charged base molecules and are mainly used in fields such as medicine.

But as I said before, the domestic production technology for commercial extraction columns is not up to par, so we cannot produce them and rely entirely on imports.

Who can afford that?

Seeing Li Shu nod, Sun Bomin said again, "Why don't you come up with something with some real technical content? You have such a useful little brain, stop trying to copy other people's ideas all the time."

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His previous research and development of magnetic beads had shown him Li Shutian's imaginative ideas, which left a deep impression on him.

At the time, he even went so far as to argue with Liu Yaoqing, hoping to get Li Shu to come to the Institute of Chemistry.

Yesterday I heard that Bao Yaning had inquired about chemical modifications, and I immediately guessed that Li Shu might have a new idea.

He said at the time that Li Shu's improved Stobber method was very innovative, but its greatest significance was that it found a way to decouple the functional core from the interface.

Then, in the field of nanomaterials, it has absolutely enormous research value.

He thought Li Shu had some new ideas and should explore nanomaterials, so he took the initiative to come over and ask him.

Little did anyone know, Li Shu was still studying methods from ten years ago, which, in his view, was nothing more than copying others' ideas.

Li Shu wanted to refute it, but after thinking about it carefully, he realized that what he said made sense.

But since there are readily available and usable methods that can balance efficiency and cost, why not use benzenesulfonic acid groups?

"Academician Sun, the main reason I'm working on this is to explore magnetic solid-phase extraction."

Faced with a powerful figure who wouldn't even look at a feasibility report, what could Li Shu do but explain his own ideas?

"etc!"

Before he could finish his sentence, Sun Bomin abruptly interrupted him, glaring at him and demanding, "What did you say? Magnetic solid-phase extraction?"

Li Shu nodded, about to explain why they were doing this, when Sun Bomin's expression suddenly changed as if he had just had an epiphany. He stared wide-eyed and muttered to himself, "That's right, the functional core, then it can be directly purified and extracted. Just use a magnet to attract it and it's done."

"Then, wouldn't all the silane modification groups be able to be transferred onto magnetic beads...?"

"Holy shit!"

Sun Bomin suddenly swore, which startled Li Shu.

"Damn it, how come I didn't think of that?"

Sun Bomin scratched his increasingly thinning hair, still muttering to himself, "Magnetic beads are used for naphthalene purification, so they can also be used for extraction."

"With this, why would we need to spend money on extraction columns? We can synthesize a batch of magnetic beads for repeated use; how much money could that cost?"

As he was speaking, he suddenly looked up and stared intently at Li Shu.

Li Shu felt a little uncomfortable under their stares.

"You've got some brains, you're really something, impressive." Sun Bomin gave a thumbs up, looking completely convinced.

Li Shu was about to speak when Sun Bomin interrupted him again.

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He was excited and said, "Your method is great, it's fantastic! Just think about it, in medicine, food, chemistry, biology, and all those laboratories across the country, who doesn't use this extraction column?"

This thing is a basic consumable in the laboratory.

"It's so expensive, a box costs several hundred US dollars and can only be used a few times. Moreover, we can't produce the column tubes, sieve plates, and packing materials for this stuff. With magnetic beads, wouldn't that be a workaround?"

"They don't even need a vacuum manifold, how much money can they save?"

The research, frankly speaking, is all about money.

You need money to do research; without money, you can't do any research.

Anything that can reduce costs is a good thing.

Sun Bomin became more and more excited as he spoke, and involuntarily stood up, pointing at Li Shu and saying, "Li Shu, hurry up and write your paper, I'll help you submit it, and then we'll apply for a patent. The method of coating magnetic beads is something you developed yourself; it's an exclusive secret."

"We'll produce magnetic beads too, and sell them. We'll sell each tube for five hundred US dollars, no, a thousand. Damn it, we're always out of stock of extraction columns. Who are we trying to disgust?"

He was already fed up with the constant shortage of imported consumables and the problem of not being able to buy them even when he had the money.

It's time to turn things upside down and disgust people.

"Academician Sun, please don't get agitated." Li Shu quickly stood up and pulled Sun Bomin to sit down.

Sun Bomin was so excited that he said, "Li Shu, I'm serious. You have to write this paper. Think about it yourself. There are so many silane modification groups, and the application fields are so wide."

"It's not just silicon-based coating; other materials work too, like polymers. And there are also modifying groups, like amino and carboxyl groups, that works too."

"Li Shu, you're going to start a new school of thought, which will inspire a lot of research. Don't take this lightly, hurry up and finish your paper, or someone will steal it from you."

"No, I have to find Old Liu and have him keep an eye on you. That old guy, he didn't even think of that, he's not even as good as me."

Using magnetic beads purified from sodium for solid-phase extraction seems like a logical step at first glance.

But I just didn't expect that before.

But Li Shu had an idea and immediately broke through this barrier.

He excitedly stood up and was about to leave.

Li Shu quickly grabbed him and said, "Academician Sun, can you let me say something?"

This is just the beginning; we haven't even gotten to the important stuff yet.

Sun Bomin was startled and gasped, "You little rascal, you don't have any other ideas, do you? Come on, tell me quickly, let me see for myself."

He pulled Li Shu down to sit.

Li Shu remained silent, thinking that Sun Bomin's personality was just like that of an old rascal.

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After handing over the tea, Li Shucai explained his idea: to measure the presence of drugs in sewage to achieve overall monitoring and trace the source.

"Academician Sun, the amount of toxins in the wastewater must be very low, possibly at the nanogram level, so it is necessary to enrich it. However, using a traditional extraction column would be too costly and inconvenient to operate."

"I'm considering using magnetic beads, which can reduce costs and achieve high enrichment, reaching a level that can be detected by instruments."

"Academician Sun, your institute has the most complete and advanced liquid chromatography-mass spectrometry (LC-MS) equipment. Could you help me analyze whether it can realize my idea?"

According to the system documentation, it is technically feasible, and there is a lot of successful application experience.

But that's the future. In this day and age, if Li Shu wants to replicate it, he needs an authority to help him evaluate it.

"It's drugs again."

Sun Bomin frowned and said, "Stop messing around with your little gadgets. Research something bigger, something meaningful, something that will help all of humanity."

In his eyes, solving a case is a trivial matter.

"By the way, you mentioned enrichment, that's right. Using magnetic beads eliminates the limitations of the column and allows for repeated stirring, which means enrichment can be performed on large samples. That's a great method."

"Let's go, let's go find Old Liu."

He grabbed Li Shu and left.

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