I have a traffic system

Chapter 229 “Rapid detection technology based on CRISPR”

Starting in May, Wu Zhou's Aiying Medical has begun to produce results, such as related equipment for virus detection.

It was originally a special research and development project carried out by the company for the purpose of researching virus purifiers, but we did not expect the surprise of unexpected derivatives.

"Rapid detection technology based on CRISPR."

The latest research by a team led by "Aiying Medical and Aiying Biogene Editing" celebrity Dr. Zhang has found that CRISPR_Cas9 can specifically cut DNA under the guidance of gRNA to achieve gene editing functions, thereby enabling rapid gene detection (Cas13, Cas12a,

Csm6), related articles have been published in Nature and Science.

Compared with traditional molecular diagnostic technologies such as PCR and NGS, CRISPR detection technology is more sensitive, anti-interference, more accurate and more convenient to use.

Traditional PCR requires dozens of copy units of viruses to detect, while CRISPR detection technology only requires 1-3 copy units.

The sensitivity is dozens of times higher.

And it is more convenient in use scenarios. It does not require large instruments or laboratories and can be used at home."

so.

As a result, after a large number of clinical trial results were verified, China provided an accelerated approval process.

If everything goes well, production should be able to start at the end of May or early June. Aiying Medical is already working on the relevant production lines. All the existing production lines will need to be adjusted.

This major news was published in relevant authoritative journals in mid-May. As the temperature of masks is rampant around the world, countless people have noticed its harm. During this time, related technologies and articles have been published on

Top journals such as sci and nature are particularly easy to apply for and can be published very quickly.

The emergence of this technology has attracted great attention from the global medical industry because its data are ahead of other similar detection technologies.

Dr. Zhang became famous all of a sudden.

There is also an endless stream of interviews from domestic and foreign media.

"The fact that this technology can be implemented so quickly is not only due to me, but also to the help of my team members and other colleagues in the company. Without their help, it would be impossible to get the results so quickly." Dr. Zhang

But he said it with a serious face.

He told the truth.

Because the entire research and development process, even looking back on it now, was unexpectedly satisfying.

If we encounter a slight problem, other members of the group may suddenly have a flash of inspiration and give them the right direction.

Or maybe other groups in the company happen to have experts in related fields who can help solve the problem.

In addition, the members of the team have super strong execution ability.

I feel more comfortable than ever before. It seems that I only provide a general direction, ideas, and then the specific implementation process, and I don’t seem to need to worry about it.

He was extremely lucky at the moment, having agreed to the headhunting company's invitation out of anger.

But Dr. Zhang told the truth, viewers who saw the relevant interview.

But I feel that Dr. Zhang is being modest.

"A humble gentleman."

"This is what our Chinese scientists should really look like."

"Wu Zhou's luck must be very good. He just entered the medical field and won a big name. The important thing is that he also produced results."

"This stuff has been researched and found to be of some use, but it is gone in the country. Only one or two pop up occasionally."

"You are in Shangougou. Check out the international news. Millions of new people are being added every day abroad. I don't know how many people are actually there."

"Haha, so what, foreign technology is much more advanced than ours in China."

At the same time, many domestic and foreign medical institutions that are interested in paying attention to this technology are also following up to verify the feasibility of this technical route.

After all, the current global nucleic acid program is very uncomfortable, because the number of viruses required is much higher, so it must be severely poked in the nose, which makes many people feel psychologically disgusted and even resisted.

But if this kind of ultra-sensitive technology is used, the nucleic acid experience will be much better.

The second is timeliness. Current nucleic acid solutions generally take more than 6 hours to produce results.

The timeliness of Dr. Zhang's solution only takes about half an hour, and there is even room for further improvement.

In addition, the accuracy is high, the detection is convenient, and even the cost is not high.

Taken together, the results are obvious.

After the internal laboratory verification was correct, the person in charge of the relevant pharmaceutical group began to contact Wuzhou Company, hoping to obtain authorization for this patented technology.

Wu Zhou has full confidence in this technology. The results given by the system are the best technology at the moment and the best in almost all aspects. Even if the technology is announced now, other related companies at home and abroad will follow up immediately.

Relevant technology research and development will take at least several months, but this is based on a similar route.

As for the technology patent, Wu Zhou has asked the company's lawyers to apply for patents in major markets around the world. The company is also studying some related technical routes, and has made certain progress.

Moreover, patents can not only be applied for after the finished product is completed, but also the technology can be divided into many small technologies.

What is certain is that it is very difficult to circumvent Wu Zhou Company's patents and it is unlikely to achieve results in the short term.

On May 19, the first American company wanted to cooperate and offered US$10 million in the hope of obtaining global authorization, but Wu Zhou didn't even respond.

On May 21, three more companies contacted, but Wu Zhou only contacted one of them. It’s not that this company is big, it’s just because this company has a pretty good drug, and Wu Zhou wants to get the authorization.

As the internal verification results of each company are released one after another, more and more companies are contacting Aiying Group.

On May 31, after a screening process, Aiying Group invited the heads of China from eight pharmaceutical companies to gather in Yuncheng.

In a silent conference room, an 8-meter-long wooden conference table was placed in the middle of the room. A white door that opened inward separated the room from the outside world. On the ground

There is a thick white floor tile, and the sunlight coming through the window makes the whole room look particularly bright.

Wu Zhou was sitting at the main seat, surrounded by the company's technical staff, legal affairs, and business negotiators. On the other side were representatives from other related pharmaceutical companies, including Chinese and white people. At this moment, the two sides were sitting face to face, and the atmosphere was tense.

And looking forward to it.

"First of all, thank you all for coming. As a newly established biopharmaceutical company, I would like to thank you for your attention and recognition of our company's related technologies." Wu Zhou said with a smile.

"Mr. Wu is very polite. We are still the most powerful company in the field of biomedicine. Being established early or late does not mean that the company is strong or weak. We also admire Mr. Wu's heavy investment in the field of biomedicine. I believe that in the future,

There will be more cooperation opportunities with Mr. Wu’s company." Someone said with a smile.

The project is not being discussed yet, so of course Wu Zhou is being coaxed into talking about it.

"However, we had heard about Mr. Wu's achievements in the food field before we came here. The food of Qiao Fei's family is indeed very good. I believe that the future Aiying medical-related products will definitely be popular among Mr. Wu.

Under the leadership of the company, we will make better products and benefit countless patients.”

After a bunch of complimentary opening remarks, formal business negotiations begin.

"I believe that everyone who is working on this technology must have already understood it before coming here. This is the most advanced technology at the moment." Wu Zhou said confidently.

"Mr. Wu, your company is indeed ahead in the application of this technology this time, but I think Mr. Wu must also know that the United States is the first to start research on CRISPR-related companies and teams, and is a technology pioneer in this industry.

"A white man in a suit said to Wu Zhou seriously, the price is negotiated.

Things are more valuable when they are rare. As long as your opponent feels that your things are not rare enough, then of course the price will not be worth it.

"Gunpowder was invented by us in China first, but after a while, you used it better than us, didn't you?" Wu Zhou responded with a smile.

Although this technology is, as he said, the United States is more advanced and has even been applied to the clinical stage.

But this time Dr. Zhang's team has developed a new type of gene editing tool based on this technology, making it more accurate, specific and wider in application.

The confident gesture Wu Zhou showed at this moment made the person in charge of a pharmaceutical company opposite him, and the person in charge of a group of pharmaceutical companies opposite him, look at each other in disbelief.

They couldn't tell whether Wu Zhou was pretending on purpose or whether he really knew about the research progress abroad.

But Wu Zhou no longer planned to chat with them.

It's time to get down to business. The purpose of these people's coming is to obtain the global license for this technology. After expressing their ideas, they will directly give a quotation.

"Mr. Wu, our company invested 30 million US dollars for this reason. This is the highest price I can get." It was the white person in charge of the pharmaceutical company just now.

Wu Zhou glanced at him. "That's such a pity. It seems that there is no chance for us to cooperate with your company."

When other people saw this scene, the price also increased sharply.

As more and more people make bids and more and more competitors come in, prices begin to rise.

100 million US dollars, 300 million US dollars, 500 million US dollars, the highest even reached 1.5 billion US dollars. It was like a bidding market.

"It's too high, you are crazy." The person in charge of the pharmaceutical company who quoted 30 million couldn't help but criticize others around him.

Although this technology is the most advanced at the moment, at least it is only for now. As long as someone comes up with a technology update and is better than this technology, the patent licensing fee will be wasted.

Besides, masks seem very serious now, but they may not last long in the future. Spending US$1.5 billion on one is uncertain, which is crazy.

"Thank you for your recognition of our company's technology. The application process of new technologies will inevitably bring risks, such as being replaced by more advanced technologies. Our company will not do this and leave all risks to our partners."

"Although making money is important, to me, it doesn't matter whether it's more or less. My original intention of entering the medical field was just to make good products and benefit ordinary people."

"This is a technology related to detecting masks. Now everyone is clearly aware of its seriousness. I hope this technology can benefit the general public faster and make some contribution to preventing its further spread."

After Wu Zhou said a lot.

"Therefore, our company will not consider the buyout authorization for the time being. What I hope is a share authorization, with a ratio of 30%."

"Mr. Wu, some of us still want to win global channel authorization."

But Wu Zhou was resolute.

Wu Zhou's plan does make some people excited, after all, it can greatly reduce this risk.

"Mr. Wu, the ratio of 30% is too high. We can only agree to 10% at most for related technical cooperation patent fees. Do you think?"

"Of course there is no problem. I can accept 10%, but there are additional conditions. If this cooperation is established, then our company will only need to pay 10% as an agent for some of your company's products?"

After some back-and-forth negotiations, it was finally determined that it was all 20%.

(End of chapter)