A genius? I just love studying.

Chapter 316 Editor-in-Chief of *Cell*: We're Far Ahead
“Strange phenomena have emerged in laboratory animals and subsequent complex organoid models.”

In the laboratory, Tang Jian played a series of data and said to Chen Hui, "The adaptive drug Locksmith No. 1 has brought unprecedented selection pressure, which has accelerated the evolution of cancer cells."

Instead of producing single drug-resistant mutations, they begin to exhibit a series of synergistic mutations. These mutations not only render drugs ineffective but also make cancer cells more malignant, with stronger proliferation and metastasis capabilities.

"What's even more alarming is that we discovered that when these smart drugs attack the main mutated pathways, they unexpectedly activate other ancient, normally silent signaling pathways related to embryonic development, such as Hedgehog and Wnt."

This seemed to echo within the cancer cells, awakening their deeper, more fundamental survival mechanisms. Although the tumor shrank temporarily, it became more malleable and harder to eradicate completely, like a centipede that, though dead, does not stiffen.

On the large screen in the conference room, X-ray images of tumors in laboratory mice were being played, and the eerie swelling felt like a heavy hammer blow to Chen Hui's heart.

What he worried about most happened.

"Let's go check out the lab."

After carefully reviewing the data and photos compiled by Tang Jian, Chen Hui's expression grew even more grim, but he was still unwilling to give up and wanted to see it for himself.

In the laboratory, Chen Hui stared silently at the cancer cells in the petri dish, which had become increasingly bizarre and tenacious under the influence of drugs.

He suddenly realized that what he had designed was not the ultimate weapon to kill cancer, but a powerful evolutionary catalyst. Instead of killing the demon, it forged it into stronger armor and weapons.

At that moment, Chen Hui suddenly felt immense pressure.

He thought of the death of the girl whose name he still didn't know.

No one knows if the uncle's condition will suddenly worsen, or if it will deteriorate like that girl's, leaving him only a few days to live...

Chen Hui's face was pale.

He felt unprecedented pressure and self-doubt; the pride of a genius was shattered by reality.

In the past, no matter how difficult the problem was, Chen Hui was confident that he could solve it. Because he had a proficiency panel, he believed that even if he couldn't solve it now, as long as he kept improving his proficiency, he would be able to solve it one day.

Therefore, he has always maintained a good mindset, able to remain calm and detached in the face of any changes.

But now, his research concerns his uncle's life or death, and he has never felt such pressure.

"Let's continue to observe and see how things go, keep a record, and then I'll study it further and see if I can think of any other solutions."

Chen Hui remained silent for a while before speaking again.

He is now the backbone of the laboratory; he cannot fall!
After Tang Jian and the others left, Chen Hui sat in the small conference room, his brain working overtime, repeatedly replaying all the data, all the models, and all the failures.

Slaughter...attack...suppression...block...these words filled his mind.

But what is the essence of cancer? It is the infinite proliferation of life.

“Infinite proliferation…” he murmured to himself. This was one of the most primal and powerful abilities of life, but it had been activated at the wrong time and in the wrong place.

……

Chinese scholars have discovered a new mechanism of drug resistance in lung cancer, and combination therapy may be able to reverse it.

Song Chaoming's team solves the problem of osimertinib resistance.

Just as Chen Hui and his team were troubled by new problems, Song Chaoming's team finally published their paper on non-classical pathway research of specific EGFR mutants.

Even though it was published in a new journal like "Huaxia Mathematics," which doesn't have much industry influence, such explosive news still attracted media professionals from all walks of life like a swarm of fish, just like the smell of blood.

Of course, the influence of "Chinese Mathematics" in academic circles may be average, but its popularity is not low. After all, it is a journal founded by Chen Hui, a legendary Chinese mathematician, and the first issue published such a heavyweight result as the proof of the Riemann Hypothesis.

Even before it has garnered widespread attention in academic circles, this paper has already sparked heated discussions online.

[Holy crap, Chen Shen is awesome! So all that silence for so long, turns out he'd been researching cancer. This is great news for cancer patients!]

Although what you said sounds a bit strange, I agree with you. Every time Chen Shen starts researching something, it's predictable that it will soon no longer be a problem.

[Don't celebrate too soon. This is just a preliminary study showing a solution to drug resistance; it doesn't mean cancer has been completely cured. We still need to see the results of further research. Cancer is not so easy to cure.]

Don't panic, hold on tight to Chen Shen, good news will come soon.

[I don't know why people always doubt Chen Shen. Since I, Chen Shen, have taken action, isn't a minor cancer a piece of cake? Haven't those who question Chen Shen been slapped in the face enough?]

In the lab, Xu Xin smiled wryly; people really do want to laugh when they're feeling helpless.

As a fellow doctoral student researching cancer, he certainly knew the difficulty of completely curing cancer, and he could understand Chen Hui's paper, but it was still a long way from completely curing cancer.

But these fans online don't care about anything at all. The way they praise him is as if Chen Hui has been completely cured of cancer, which is really quite funny.

Of course, he himself also admired Chen Hui very much. For a mathematician to be able to achieve this level of cross-domain research is already beyond imagination. That guy really can always produce amazing results once he starts researching something.

However, he still firmly believes that it is almost impossible to completely cure cancer, even if that person is Chen Shen.

……

Germany, Max Planck Society
At the Institute for Controlled Nuclear Fusion, Schultz emerged from the laboratory, looking exhausted.

As early as six months ago, they reached a cooperation agreement with China, providing money and a large amount of resources to purchase China's nuclear fusion power generation technology.

Such technology naturally requires top scientific talents to digest, especially Chen Hui's plasma operation model, which only top mathematicians like Schultz can perfectly absorb and apply with ease.

Therefore, when they were accepting technology from China, they gathered almost all the top experts in related fields across the country.

After several months of study, their experimental reactor has been built. Once the verification is completed, they can begin construction of the nuclear fusion power plant.

Of course, they also have their own ambitions in gathering so many experts.

Temporary setbacks do not mean permanent backwardness. They have always been at the forefront of research in the field of controlled nuclear fusion. They believe that after digesting China's technology, they may be able to catch up and even overtake China.

So even after the experimental reactor was completed, Schultz continued his busy research.

He had to admit that Chen Hui was a genius. His plasma operation model was so perfect that he couldn't find a single flaw. In fact, after studying it for nearly half a year, he still couldn't find any way to improve it.

Upon realizing this, he changed his mind, having originally planned to go back to his room to rest, and headed to his office.

Although he has been studying Chen Hui's model these days, he has not neglected to keep up with the international forefront of mathematics. Although he is no longer young, he still has a strong ambition in mathematics.

When I arrived at the office, I suddenly saw the email notifications I had subscribed to.

The latest issue of "Huaxia Mathematics" has been published.

Others might think that the only interesting thing about "Chinese Mathematics" is that article on the Riemann Hypothesis. Although Terence Tao's subsequent research is top-notch, it can only be considered first-rate. There are no other noteworthy articles after that, so they naturally wouldn't waste their time subscribing to such a journal.

Schultz, however, did not think so. He believed that Chen Hui would sooner or later give the world a huge shock, and the platform for the next shock would definitely be "Huaxia Mathematics", so he kept a close eye on it.

Non-classical pathway research on specific EGFR mutants

"He actually went off to study cancer?"

Schultz muttered to himself. He had already seen Chen Hui's name in the author list. Although it was only his third work, he believed in the role Chen Hui played in it.

Since it was Chen Hui's paper, Schultz wasn't in a hurry to do other research. He printed out the paper and began to study it carefully.

……

At Princeton, Deng Leyan walked into Fefferman's office with a stack of papers. "Professor, you might be interested in this paper."

He is now Fefferman's doctoral student. Thanks to Chen Hui's instructions, Fefferman has been very supportive of him, and as Deng Leyan has shown his talent, Fefferman has grown increasingly fond of the young man, truly considering him his student. Because of the strength demonstrated by China, S.H.I.E.L.D. has stopped making things difficult for Deng Leyan, allowing him to thrive at Princeton.

"Oh?"

"What paper?"

Fefferman took off his reading glasses and looked at the paper in Deng Leyan's hand with considerable curiosity.

Deng Leyan handed over the paper, "An article from the latest issue of Huaxia Mathematics."

"Chinese Mathematics?"

Fefferman paused for a moment, then realized, "It's a publication founded by Chen Hui?"

"Has he proven another Millennium Problem?"

Fefferman immediately became interested.

"It's not the Millennium Problem anymore; he's switched to studying tumors."

"Tumor?"

Fefferman's eyes widened. "Isn't this ridiculous?"

"Why waste your talent on a perfectly good subject like mathematics and go into biomedicine!"

"I heard his uncle has lung cancer." Deng Leyan was, after all, from Chengdu, and was more informed about news from China than Fefferman.

Fefferman remained silent.

If that's the case, he really has nothing to say.

But then it suddenly dawned on him: if Deng Leyan had asked him to look at the paper, wouldn't that mean, "Could it be that he really has made a breakthrough in his research?"

"Please take a look at the paper first."

……

In a courtyard house in Beijing, Mr. Qian looked at the paper he couldn't understand at all, a broad smile on his face, and then looked at the other elderly people in the courtyard.

"Look, now you know what a genius is!"

"This is genius!"

"Do one thing, and you'll excel at it!"

"It's only been a short time, and he's already achieved such significant results. Maybe he really can find a cure for cancer!"

Lin Zhengtian was also all smiles; he was even more cheerful than Qian Lao.

"Hey, Lao Zhao, why aren't you saying anything?"

"Didn't you used to be the most loud and boisterous?"

"What, did you take some kind of mute drug today?"

He vividly recalled that when Chen Hui was researching cancer, Old Zhao had given him a lot of negative feedback and even argued with him about it.

Old Zhao did not speak.

The other elderly people were in good spirits. Chen Hui's findings could be used not only for cancer but also for other diseases, which was great news for them.

"Chen Hui is truly a lucky general for China!"

Old Li sighed, which was unanimously affirmed by everyone in the courtyard. Chen Hui had brought about four or five key changes to China over the years. Anyone else who could accomplish any one of these would be recorded in history and leave a lasting mark on the annals of time.

Chen Hui actually made four or five pieces in a row, and given his age, it is foreseeable that he will be able to produce even more in the future.

They're growing to like Chen Hui more and more these days.

……

The editorial office of the journal *Cell*

The deputy editor stormed into the editor-in-chief's office, carrying a stack of papers. "My God, Charlie, look at this paper!"

"The fact that such a major breakthrough in biology was published in an obscure mathematics journal is the greatest insult to our Cell."

Charlie sat behind his desk, smiling as he looked at Lumian. "You mean that paper in Chinese mathematics?"

"You've already seen it?"

Lumian was somewhat surprised. He was not surprised that Charlie had already read the paper, but that Charlie could still maintain such a good attitude after reading it.

"Of course!"

Charlie said with a smile, "Such a groundbreaking breakthrough has been hotly discussed in academic circles for a long time. How could I not know about it?"

"Don't you feel regretful?" Lumian asked, puzzled. "This was originally supposed to be the cover article for Cell!"

Charlie shook his head repeatedly, "No, you're wrong, it doesn't deserve to be the cover article!"

Lumian was startled. "Could it be that there's been some new breakthrough recently?"

"I also have a paper here, would you like to take a look?"

Charlie smiled without saying a word, picked up a stack of papers from the desk, and handed them to Lumian.

The paper's author was Diana, Lumian knew, as it was the name of the head of the world's leading cancer research center, the Dana-Farber Cancer Institute.

This is followed by the paper's title: "Pan-cancer analysis reveals the master switch for bypass drug resistance, targeting the PKA-mTOR signaling axis."

Although Lumian was just an editor, he usually paid close attention to cutting-edge biological science. When he saw the title, he roughly guessed what it was about. He didn't care about anything else and sat down on the sofa next to Charlie's office to start studying the paper.

Two hours later, Lumian looked away from the paper, a smile appearing on his face. "What a pity. That research by the Chinese was quite good, but compared to this paper, they are as immature as babies."

So what's there to regret?

Charlie said with a smile, "This paper is more than worthy of being the cover of the next issue of Cell!"

"It's a good idea for them to increase the influence of their journal, but unfortunately, they've run into trouble this time. Once this article is published, I'm afraid no one will care about that paper anymore."

"If he had published it in Cell, it might have left a small mark on the history of cancer research."

"Running a journal isn't that easy. Chen Hui is indeed quite good at mathematics, but we haven't seen Gauss or Euler start a journal, have we? Running a journal isn't that easy!"

Lumian laughed happily, "Although they are ahead in seventh-generation fighter jets and nuclear fusion, we are ultimately superior in cancer research."

"No, it's far ahead!"

The two looked at each other and burst into laughter.

(End of this chapter)