After being fired, I became the light of medicine

Chapter 246 The Truth - TEF Glycoprotein! (Happy New Year!)

"How's the situation?"

"Boss, there are some signs of progress."

"In the past two or three days, we have extracted sufficient blood samples and biological tissues from 32 critically ill patients. After a few days of analysis, we have found that dozens of microbial and blood indicators in Xia Xue's body are significantly higher than those of other patients."

"At the same time, we found more than ten types of residual factors that have never been discovered before in Xia Xue's blood residues. However, we don't know which indicators or substances affect the effect of drug treatment. We need more detailed analysis and verification one by one!"

"Well, thank you for your hard work, Wei Tian."

In the biological laboratory of Qingshan Pharmaceutical's Drug Research and Development Center, where the first project team is located.

Zhang Yang listened carefully to Wei Tian's latest report and nodded gently in approval.

"By the way, please arrange an analysis project for me. I also want to participate."

"You want to get involved too?"

Wei Tian was slightly surprised.

"Ah."

Zhang Yang nodded again:
"I heard about all the patients' overwhelming support when you went to the hospital a few days ago. I was also quite shocked!"

"So, I want to do my part, too. We can't let them down, right?!"

Wei Tian was stunned, then took a deep breath and nodded:

"Okay, boss. I'll assign you a task then!"

"It just so happens that we are in urgent need of manpower. The amount of data for this experiment is too large!"

"Ah."

……

Zhang Yang's active participation is also a microcosm of the importance that Qingshan Pharmaceutical attaches to the "Ibetumumab" improvement plan.

In the following days, more blood samples and biological tissues were sent to Qingshan Pharmaceutical's drug research and development center.

Seven days after the implementation of the Ibelumab improvement plan,
Blood samples from a total of thirty-two subjects were collected every six hours for seven days, and all of them appeared at Qingshan Pharmaceutical's drug research and development center without omission!
The thirty-two patients who participated in the improvement program finally breathed a sigh of relief, twenty-five milliliters at a time, one hundred milliliters a day!
The blood loss of 700 ml in seven days was close to the limit of their human body.

While they were taking a breath, Tsingshan Pharmaceutical quietly took over the baton.

three days later.

11pm.

The biological laboratory on the first floor of Qingshan Pharmaceutical's drug research and development center is brightly lit, and more than 40 drug developers from the first project team are still working late into the night.

"Boss, it's eleven o'clock. It's the latest overtime time stipulated by the company. How about we stop here today?!"

Zhang Yang looked up at the clock hanging high in the middle of the laboratory, exhaled slightly, and nodded.

"Well, that's enough for today. Let's call everyone off. After all, health is the capital of revolution!"

"By the way, have you got the results of the analytical experiment? How are they? Is there a positive correlation with the treatment effect?"

When Wei Tian heard this, he immediately shook his head:
"The experimental results are out, but no obvious correlation was found between the experimental regimen and the treatment effect. We have to continue screening."

"What about you, boss?"

“I don’t see any connection either.”

"Okay, boss. I'll go and tell everyone to get off work."

"it is good."

After a brief conversation, Wei Tian slowly walked to the various lab tables and told everyone to get off work.

Zhang Yang's gaze gradually left Wei Tian, ​​and his thoughts returned to the analytical experiment in front of him.

Although there were only dozens of obvious "abnormal indicators" found in Xia Xue's body this time, and only more than ten unknown residual substances were found, but!
It is very troublesome to verify the correlation between each indicator and the treatment effect. There is no better way than to try them one by one!
The more than ten unknown residual substances are even more troublesome. Before verifying the therapeutic relevance, the composition and source of the unknown substances must be clarified, which also requires a lot of experiments.

"Huh... can't be impatient, I can only take it step by step."

“It was only then that I truly realized how powerful the medicine given by the simulator was!”

Zhang Yang couldn't help but sigh in his heart and a bitter smile appeared on his face.

After obtaining the drug ingredients from the simulator, I tried every means to create obstacles for the R&D team. Now that it is my turn to do completely independent research and development, I wish there would be as little trouble as possible!
After sighing, Zhang Yang slowly stood up. Seeing that everyone started to clean up the lab tables and sort out the test data under Wei Tian's call, he stepped forward and walked to the middle of the laboratory and said:
"Everyone has worked hard, just pack up and leave."

"We will delay work by half an hour tomorrow morning so everyone can take a rest."

"Is the car ready? Wei Tian?"

"Okay, ready."

Wei Tian looked at Zhang Yang, then nodded and confirmed:

"The company's shuttle buses are ready, and the three drivers are waiting in the buses. Just like before, there are three buses going in different directions. Everyone can take the bus that goes in the direction they want to go home."

"Okay, Director Wei, we know."

Many colleagues in the laboratory responded, and Zhang Yang also showed a satisfied smile on his face.

Seeing that several colleagues had already packed up the lab table and were ready to leave, Zhang Yang suddenly noticed that there was another colleague in a corner not far away who was still lowering his head and seemed to be monitoring the experiment.

He was slightly surprised and walked over slowly. When he got closer, he could barely remember the name of the drug developer from his back - Qin Xiaohua.

Qin Xiaohua had only been working at the company for a short time, and was not even a drug researcher in the first project team at the beginning.

If he remembered correctly, Qin Xiaohua was supposed to be in the sixth project team? Or a researcher in the eighth project team. It was only after Wei Tian summoned most of the researchers in the R&D center to sprint the progress of "Ibeumab" that Qin Xiaohua took the initiative to stay in the first project team and officially switched from the previous drug research and development track to the research and development of leukemia drugs.

Thinking of this, Zhang Yang's pace quickened. It was a good thing to focus on the experiment, but it was indeed a little late today.

But just as he walked behind him, Qin Xiaohua suddenly trembled all over, and then shouted excitedly:
“Found it, found it!”

"Team Leader, I found it, I found it, I found it!"

Zhang Yang was startled, but when he heard clearly what Qin Xiaohua shouted, he was also shocked. His originally relaxed expression suddenly became tense, and he asked excitedly and even with a hint of expectation: "Qin Xiaohua, what's wrong?! What did you find?!"

Qin Xiaohua was so focused on the experiment that he didn't notice that Mr. Zhang Yang had quietly appeared behind him!

After being stunned for a moment, he looked around and realized that not only was Mr. Zhang standing behind him, but his colleagues had also basically cleaned up the lab benches and were ready to go off work!
Oh my god, it's already eleven o'clock at night? ?
hiss!
I was so focused on the experiment that I didn’t even notice everyone’s situation!
"Qin Xiaohua, what are you staring at? Tell me, what did you find out?"

Qin Xiaohua's loud shout naturally attracted the attention of all his colleagues, and everyone stopped and waited for him to tell about his new discovery.

But after Mr. Zhang's question, instead of answering him promptly, he froze in silence, which made the team leader beside him hurriedly remind him.

Fortunately, Qin Xiaohua finally reacted. He looked at Zhang Yang in front of him and recalled the experimental results he had just obtained. He became excited instantly:
"Mr. Zhang, I found an unknown substance factor that is positively correlated with the therapeutic effect!"

!!!

Zhang Yang's expression suddenly brightened up, and his heartbeat quickened!
I actually found something!

After a moment, he suppressed his excitement and said in a deep voice:
"Don't worry, take your time!"

Not only Zhang Yang, but everyone in the biology laboratory moved over instantly. Even a few colleagues who had already walked to the door and were ready to leave turned back and moved over!
Are you kidding? Who doesn't want to know what Qin Xiaohua discovered?!
Qin Xiaohua came to his senses:
"Mr. Zhang is always like this!"

"Didn't we find some unknown factors in Xia Xue's blood sample a few days ago? Of course, the more accurate term should be factors that have not yet been extensively researched."

"The experimental task assigned to me is to analyze one of the unknown material factors and find out its composition, source and function!"

"After several experiments, I confirmed that this unknown substance factor is a glycoprotein secreted by a special subtype of immune cell subsets - CD8+T cells."

"For the sake of record, I have previously named this glycoprotein secreted by a special subtype of CD8+ T cells Target-enhancing Factor, or TEF for short."

"Besides, I want to correct a mistake here."

"We previously thought that this unknown substance factor, TEF glycoprotein, only appeared in Xia Xue's blood sample, but after I analyzed the blood samples of other patients in detail again, I found that TEF glycoprotein not only appeared in Xia Xue's blood sample, but also in the blood samples of other patients!"

"only!"

"The concentration of TEF glycoprotein in Xia Xue's blood is much higher than that of other patients, and the cell signal is very active, while the concentration of TEF in the blood of other patients is low and very stable, so it is difficult to detect without using special methods!"

Zhang Yang was slightly stunned.

Immune cell subsets - CD8+T cells, which are normal immune cells in the human body.

Actually,
The operating logic of immune cells in the human body is actually similar to that of normal cells. They also go through the process of generation to exhaustion, so when operating normally, immune cells will also secrete various glycoproteins and cellular metabolites.

It’s just that because the glycoproteins secreted by various immune cells are different, and the secretion content is extremely low and the structure is stable, the pharmaceutical community generally regards them as substances produced by the normal metabolism of immune cells, so there has been no further in-depth research.

Could it be!

Is the reason why "Ibetumumab" has such a significant effect in Xia Xue's body because it is related to this TEF glycoprotein? !
Qin Xiaohua also saw Zhang Yang's doubt and urgency, and said hurriedly:
"Mr. Zhang, you know!"

"The original intention of designing our 'ibactuzumab' was not to be an inhibitory targeted drug, but a killer that directly targets antigens on the surface of leukemia cells!"

"The core principle of drug design is to use drug components to bind to the surface antigens of leukemia cells, thereby determining which cells are leukemia cells and which are normal cells, and then identifying and killing them!"

"But everyone has seen the effects in clinical trials. The fluctuation rate of treatment effects is very large, so I guess the biggest possibility is that the unstable binding efficiency of 'involumab' with leukemia cell surface antigens causes drastic fluctuations."

"And it just so happens that the high concentration of TEF glycoprotein in Xia Xue's body seems to be just the right thing for Ibamivirus to better bind to the surface antigens of leukemia cells!"

"This is also the result I got from the experimental analysis just now!"

Zhang Yang was shocked, his face full of shock!

Dozens of top pharmaceutical professionals who had gathered around were also surprised. A TEF glycoprotein secreted by immune cells could actually allow Ibamivirus to better bind to the surface antigens of leukemia cells? !
This... this is a discovery that has never been made before!
"Qin Xiaohua, what is the principle behind this? Do you know how it is achieved?!"

Qin Xiaohua smiled bitterly, shook his head, and said:
"Mr. Zhang, I have just verified the positive correlation between TEF glycoprotein and the therapeutic effect of 'ibukumab'. I don't know why and by what principle it can better bind to the surface antigens of leukemia cells."

Zhang Yang took a deep breath, then took the experimental results handed over by Qin Xiaohua and quickly scanned them. Half a minute later, he handed it to Dr. Zhou, the project team leader.

A minute later, Dr. Zhou also nodded heavily.

"This TEF glycoprotein does have a significant positive correlation with 'ibukumab'!"

"Boss Zhang, how about we work overtime tonight and find out the exact reason?"

As soon as he finished speaking, before Zhang Yang could say anything, the researchers who were watching were all ready to go, and the sleepiness of the late night was swept away.

What could be more exciting than discovering a "new world"?
"it is good!"

Zhang Yang nodded, but soon changed the subject and looked at the other R&D personnel present!
"But don't stay up late, go back and rest first, and continue the battle tomorrow!"

"Tonight, let me, Zhou Bo, Wei Tian, ​​and Qin Xiaohua work overtime together to find out the situation of TEF glycoprotein, okay?"

"How's it going, Xiaohua?"

"it is good!"

Qin Xiaohua naturally agreed without hesitation and was very excited.

……

With a specific research and development direction, Zhang Yang, Zhou Bo and Wei Tian are all truly top-notch drug developers.

Overnight, more secrets about TEF glycoprotein were revealed, including how it was connected to "ibukumab", and the pathway and principle through which it better combined with the surface antigens of leukemia cells.

At 8:30 the next morning, the developers of the first project team rushed to work and reached an accurate and clear conclusion.

TEF glycoprotein is indeed secreted by a specific subtype of immune cell subset, CD8+ T cells.

When the concentration of TEF glycoprotein in the blood becomes high, TEF glycoprotein will fully and specifically bind to the FC segment drug component of "ibacterium vaccinia" and the specific receptors on the surface of leukemia cells at the same time.

simply put,
After the TEF glycoprotein binds to the Fc segment of "ibacterium tumefaciens", it will change the spatial conformation of the antibody, allowing the original antigen-binding part of the drug to bind to the surface antigens of leukemia cells more accurately and efficiently, just like a "recognition enhancer", greatly enhancing the recognition of highly hidden leukemia cells!

At the same time, TEF will also bind to the surface receptors of leukemia cells, inducing aggregation and conformational changes of leukemia cell surface antigens, further increasing the affinity of the "ibacterium vaccinium" antigen, allowing ibetuzumab to be more firmly anchored on the surface of leukemia cells, making it less likely to fall off, thereby enhancing the drug's lethality!
It can be said,
TEF glycoprotein is like a targeting factor enhancer. After combining with the FC segment of Ivacumab, it greatly enhances the ability of Ivacumab to identify latent and genetically mutated leukemia cells!

But then, a huge confusion appeared in the minds of all R&D personnel.

So!

Why are all of them suffering from severe leukemia, but only Xia Xue has such a high concentration of TEF glycoprotein in her blood?
TEF glycoprotein is secreted by CD8+T cells, a subset of immune cells.
Could it be related to immune cells?

(End of this chapter)