After being fired, I became the light of medicine

Chapter 236: Old Xia, Mr. Zhang is here!
"I agree."

As soon as he finished speaking, Dr. Zhou was the first in the conference room to raise his hand in agreement.

After a moment, he glanced at everyone and continued:
"When we first started developing 'ibactuzumab', our initial starting point was to completely cure 'acute myeloid leukemia', so the initial research and development direction was to start from the injectable preparation, just like 'ITG human myelopoietin'!"

"But now, based on the actual treatment situation we have, the best data of 'ibukumab' in animal experiments is that it can identify and kill about 80% of leukemia malignant cancer cells in the host body. The remaining 20% ​​of leukemia cancer cells may not respond well due to reasons such as dormancy or escape, and cannot be completely eliminated."

"That is to say, at present, 'ibuzumab' is likely to become a long-term injectable drug, which will accompany 'acute myeloid leukemia' for life."

"So just like what Director Wei said just now, if lifelong injections are necessary, then it would be best to develop tablets, which would be more convenient for patients to take and would increase their compliance!"

"Of course!"

“Currently, ‘ibumaxin’ is mainly administered intravenously, and the drug components directly enter the bloodstream to identify and attack leukemia cells in the blood;

If it is changed to oral tablets, it needs to be absorbed through the gastrointestinal tract before entering the blood. The whole cycle is relatively complicated, so a special oral preparation team needs to be established..."

At this point, Dr. Zhou's eyes fell on Zhang Yang, who was sitting in the middle.

Zhang Yang had a smile on his face.

As a top drug developer, he certainly knows the difference between the two.

Moreover, he was also very clear that Wei Tian and Dr. Zhou said so much, in the final analysis, they also hoped that he would agree to start the research and development of oral tablets.

After all, developing tablets requires a lot of additional R&D costs.

However, he also feels that it is necessary to develop oral tablets of "ibukumab". Patients only need to take one tablet every day, with high compliance and minimal impact on patients' lives.

"Zhou Bo, we can start developing oral tablets next."

"Then the injectable 'ibumab' can be used in hospitals and when the patient's condition is critical. After the patient stabilizes and the condition is under control, it can be switched to oral preparations when discharged from the hospital!"

Wei Tian and Dr. Zhou's expressions suddenly brightened.

Dr. Zhou said anxiously:

"Okay, Mr. Zhang, since you agree, I will arrange for the team to start developing oral tablets."

"With the experience of the targeted drug 'ibumaxin', developing oral tablets should not be a problem."

"Ah."

Zhang Yang nodded, and the atmosphere in the conference room suddenly became relaxed.

Wei Tian on the side also smiled and said:
"Boss, now that the development of oral tablets has been finalized, let's move on to the second topic of this meeting!"

"Before, we urgently mobilized almost all the R&D backbones in the R&D center because we wanted to concentrate our efforts on the 'Ibeumab' project. Now the 'Ibeumab' project has successfully entered the clinical trial stage..."

“Although there is still some gap between this and the original plan to completely cure leukemia, do you think we should lift the mobilization and allow the key R&D personnel to return to their previous R&D teams?

Or...wait until 'Ibetumumab' completes Phase III clinical trials and is officially launched before disbanding? ! "

As soon as he finished speaking, the doctors from several major project teams attending the meeting sat up straight.

Not only Zhang Yang and Dr. Zhou attended this meeting, but also doctors from major project teams of the R&D center!

Clearly, this is something they care about very much!
After a moment, before Zhang Yang could speak, Dr. Liu from the second project team couldn't wait to speak:
"Mr. Zhang, we must disband the team now and return the people to us! The first project team's 'Ibexin-1 Antibody' has already been put into clinical trials, and their original R&D team is fully capable of the subsequent clinical work!"

"Our various groups' projects have been suspended for a long time. We can't afford to delay any longer!"

After the voice fell, Dr. Liu from the second project team spoke, and immediately the doctors from the other project teams also spoke up:

"Yes, Mr. Zhang! Our third project team's 'Fatty Liver Reversal' project is also at a critical stage, and we are also in urgent need of people!"

"That's right. To be honest with you, Mr. Zhang, several researchers in our group have told me that they don't want to stay in the first project team anymore and have wanted to come back."

Upon hearing this, Dr. Zhou, who was originally waiting for Zhang Yang's decision, became unhappy and quickly retorted:
"Old Liu, what you said is sheer nonsense!"

"I haven't even told Mr. Zhang yet, but several researchers in your group have come to me privately and said they want to stay in our first project team and develop drugs related to blood diseases!"

"Humph! You're talking bullshit. Tell me who wants to stay in your first project team?!"

Hearing Dr. Zhou and Dr. Liu suddenly quarreling, Zhang Yang couldn't help but smile bitterly.

He could certainly understand the importance that the PhDs in the major project teams placed on talent. After all, only with a large number of professional R&D personnel could the process of developing new drugs be successfully advanced.

Moreover, this was also the first time for him to witness the powerful drug research and development capabilities that emerged after the Qingshan Pharmaceutical R&D Center mobilized nearly a hundred top R&D personnel!

Drug research and development, after all, is the accumulation of talent!

Thinking of this, Zhang Yang interrupted their quarrel with a smile and said:
"Okay, Zhou Bo, Liu Bo, stop arguing."

"Well, at present, 'Ibeumab' is indeed one of the most important R&D projects of our Qingshan Pharmaceutical,"

"If there are R&D personnel willing to stay in the first project team, then transfer the work department to the first project team!"

After saying this, seeing that the doctors from the major project teams all wanted to speak, Zhang Yang hurriedly continued:
"Of course, it won't happen again."

"At the same time, I am also planning to recruit more people on a larger scale and double the size of our current professional R&D staff!"

Double the size!
After hearing this, the doctors, who were originally a little agitated, calmed down a little.

Zhang Yang looked at Wei Tian and continued:
"Wei Tian, ​​I'll leave this matter to you."

"Of course, we need to recruit not only experienced R&D personnel, but also more fresh graduates, and gradually begin to cultivate our future backbone."

"it is good!"

Wei Tian was recording quickly. At this moment, Zhang Yang exhaled lightly, glanced at everyone, and then said:
"Okay, have we finished discussing the two topics of today's meeting?"

"Now, I have something to announce."

Everyone looked a little puzzled, Zhang Yang smiled and said:

“Although Ibelumab has not yet passed clinical trials and is officially on the market, the fact that it has reached this stage of clinical trials is already a huge breakthrough and an important step!”

"Wei Tian, ​​Zhou Bo, go and sort out all the R&D personnel participating in the 'Ibeumab' project. Each of them will be rewarded one million yuan!"

"Three million yuan for those who have made special contributions and performed well, and..."

As he spoke, Zhang Yang once again glanced at the doctors present:
"This time, all the doctors put aside their own projects at the most critical moment and worked together to participate in the final sprint of 'ibumab'. Thank you for your hard work."

"Similarly, everyone will receive a research and development reward of 3 million yuan each. I will then notify Mr. Qian in the finance department and it will be paid out along with the salary next month!"

three million!

The doctors present were stunned, and all their dissatisfaction disappeared in an instant!

Are you kidding? The reward is three million for each person!

You know, although they are PhDs, project leaders, and their annual salary exceeds one million, but!

Who would complain about having too much money?!

"Mr. Zhang, you are so polite. We have only done our best... Don't worry, next time there are other projects that need to be focused on, we will definitely go all out!"

"Yes, yes, Mr. Zhang, we will definitely cooperate with you. You are really the most generous boss I have ever met!"

Zhang Yang smiled and waved his hand, saying, "Since no one has any objections, today's meeting ends here. Let's adjourn!"

"Okay, thank you Mr. Zhang!"

No one expected that today's meeting would end like this. All the doctors stood up, thanked Zhang Yang with smiles on their faces, and then left.

After a while, the doctors from various project teams happily returned to the R&D center, and only Wei Tian and Zhang Yang were left in the conference room.

Wei Tian was about to speak, but Zhang Yang spoke first:

"Wei Tian, ​​do you have anything else to do now?"

Wei Tian was slightly stunned and shook his head:
"No, what's wrong, boss?"

"nothing."

Zhang Yang pondered for a moment:
"I want you to go to the Third People's Hospital with me. Wasn't there a patient who used our 'Ibetumumab' in advance?"

"Today is exactly the seventh day after the injection. Let's go and see the effect."

Wei Tian instantly recalled Xia Xue lying in the emergency room, dying, and thought of Old Xia, but just as he was about to nod, he paused, took out his cell phone and took a look.

Then he hesitated:

"Boss, it's 11:10 AM now. It should be 11:40 when we drive to Sanren Hospital."

"You came to the company at around 7 o'clock this morning and have been busy until now. How about having lunch and then I will accompany you to the hospital?"

Zhang Yang suddenly felt a little hungry, but after thinking about it, he shook his head:

"It's okay, let's go to the hospital first. If you're really hungry later, just eat something near the hospital."

"All right!"

Seeing Zhang Yang's insistence, Wei Tian did not persuade him any further, and the two of them immediately went downstairs and came to the parking lot.

30 minutes later, Wei Tian parked the car and appeared at the Hematology Department of Rongcheng Third People's Hospital with Zhang Yang.

This was not the first time that Zhang Yang came to the inpatient department of the Department of Hematology. As early as when he was developing "Qingshan Afa" and "ITG Human Myelopoietin", he often came to the inpatient department of the Department of Hematology to learn about the conditions of patients with aplastic anemia.

But even so, he was still shocked by the corridor crowded with patients.

Only when he arrived at Director Hu's office did he come to his senses.

"Director Hu, why are there so many people in the Hematology Department suddenly?"

Director Hu was not surprised by Zhang Yang's sudden visit.

In his impression, whenever there is an important clinical trial of a new drug of Qingshan Pharmaceutical, Zhang Yang will personally go to the hospital to understand the situation and the problems encountered in the clinical trial.

He took off his black-framed glasses, rubbed his temples, and replied with a look of deep fatigue in his eyes:
"Mr. Zhang, today's amount is already considered small."

"Two days ago, the day after your Ibetuzumab was released, our inpatient department, outpatient department, and clinical trial center were all packed with leukemia patients from all over the country!"

"All the patients are eager to participate in our new drug clinical trials. We can't even register enough!"

As he spoke, Director Hu put on his black-framed glasses again and took out a document from his desk drawer:
"This time, our 'ibukumab' is a combined phase I and phase II clinical trial, with a total of 104 places available."

"This is the registration data as of this morning. A total of 240 patients have registered. This afternoon I will work with your staff to screen out eligible leukemia patients for a double-blind clinical trial."

"but……"

He glanced at Zhang Yang and said:
"However, more than 30 of these patients are in particularly serious and life-threatening conditions. Now they have all gone through the admission procedures and hope that we can use the medicine directly without participating in any double-blind test!"

"Can you add 30 more direct medication quotas?"

Zhang Yang took the information handed over by Director Hu and took a quick look at it.

As we all know, all new drugs must be double-blind tested during clinical trials, that is, there is a control (placebo) group and an experimental group;
At the same time, even pharmaceutical companies, patients, and doctors do not know which patients have taken the experimental drugs, thus ensuring the authenticity of the drug clinical trials.

but.

When encountering some particularly high-risk diseases or diseases with very small number of patients, such as advanced cancer, leukemia, and some rare diseases, regulations may allow separate medication and separate records.

However, compared with the standard double-blind testing process, this method is more complicated, the approval process is very troublesome, and the credibility is relatively low, which is a burden for pharmaceutical companies.

Therefore, pharmaceutical companies generally do not make this allowance for patients.

Soon Zhang Yang handed the information back to Director Hu and nodded:

"Okay, Director Hu, since you also think it is necessary to use the medicine directly, then just apply for direct medication for these patients!"

"Save as many as you can!"

Director Hu's expression relaxed, and the fatigue on his face seemed to disappear in an instant.

He smiled and said:
"Mr. Zhang, you are here today to see the patient who first used the medicine, right?"

"She has now been transferred to the general ward. Please wait a moment. I'll get some information and take you there right away!"

"it is good!"

Zhang Yang nodded. About two minutes later, Director Hu, holding a tablet in his hand, led Zhang Yang through the corridor towards Xia Xue's ward.

As he walked, he looked at the tablet in his hand and introduced:

"Mr. Zhang, let me give you a brief introduction to the patient's condition."

"The patient's name is Xia Xue, 26 years old. She received our first injection of 'ibuzumab' seven days ago. The PET-CT scan performed when she was admitted to the hospital showed widespread increased metabolism in the bone marrow throughout the body, with obvious high metabolism in the bone marrow of the sternum, spine, pelvis and long bones of the limbs."

"These are all manifestations of advanced leukemia."

"The same is true for the blood test. The white blood cell count was as high as 231×10/L when he was admitted to the hospital. However, after one injection of treatment, in just seven days..."

"I had another PET-CT scan yesterday. The high metabolic response of the bone marrow was significantly reduced. Only the sternum still had a certain level of high metabolic response. There were no obvious abnormalities in other parts of the body!"

"At the same time, important blood indicators such as white blood cells, red blood cells, and lymphocytes are close to normal!"

"It can be said that the patient's leukemia symptoms have been well controlled with just one injection!"

Zhang Yang nodded.

At this time, the two of them just walked into the ward.

This is a two-person ward. Xia Xue is lying on the bed resting, while Old Xia is looking at his phone boredly.

Director Hu stepped forward hurriedly and said:

"Old Xia!"

"This is Mr. Zhang from Qingshan Pharmaceutical, and he came here specially to see Xia Xue's situation!"

Old Xia was startled and stood up quickly.

He only took a glance at Zhang Yang, and his expression instantly became nervous and respectful.

(End of this chapter)