After being fired, I became the light of medicine

Chapter 228: Drugs that can cure acute myeloid leukemia? !
Tsingshan Pharmaceutical Drug Research and Development Center.

In the spacious and bright conference hall, dozens of R&D backbones sat on chairs, looking at the stage with focused expressions.

"Everyone knows that leukemia can be divided into two types according to the speed of cell differentiation: 'chronic leukemia' and 'acute leukemia'."

"The world's most famous leukemia treatment drug, Gleevec, is mainly used to treat 'myeloid leukemia' among chronic leukemias, also known as 'chronic myeloid leukemia'."

"Gleevec is currently listed as the first choice drug for the treatment of chronic myeloid leukemia both domestically and internationally. Its clinical priority is even higher than bone marrow stem cell transplantation."

"The reason is very simple, because Gleevec can effectively control the progression of chronic myeloid leukemia in the long term, turning it from a malignant blood tumor into a controllable chronic disease."

"For most patients, stem cell transplantation is not recommended unless the disease worsens, suddenly develops into a blast crisis, or develops drug resistance. Instead, continuous Gleevec control is recommended."

"So... more than six years ago, when the first project team of our R&D center was first established, we focused the development of leukemia treatment drugs on the 'acute myeloid leukemia' subtype!"

"This is completely different from the 'chronic myeloid leukemia' treated with Gleevec."

The person standing on the podium at the top of the conference hall and speaking was Wei Tian. Below him, there were thirty or forty of the top researchers from Qingshan Pharmaceutical's Drug Research and Development Center sitting in a large crowd.

Obviously, at this moment, he is holding a mobilization meeting!
"certainly……"

“Although ‘acute myeloid leukemia’ is called ‘acute’, it does not mean that acute diseases in the traditional sense are easier to cure!”

"On the contrary, the acuteness here is based on the differentiation speed of malignant cells. The higher the acuteness, the faster the leukemia cancer cells reproduce and the greater their destructive power, which can cause great harm to the human body in a short period of time."

"It can be said that compared with 'chronic myeloid leukemia', the acute subtype is more difficult to treat and has a higher mortality rate. Except for some subtypes, the only effective treatment is high-dose, high-intensity chemotherapy followed by immediate stem cell transplantation!"

"There is no other way!"

As he spoke, Wei Tian paused deliberately, looking at the many researchers below the stage looking at him intently, nodded and continued:

"According to the latest disease statistics, among all types of leukemia, the incidence of 'acute myeloid leukemia' accounts for as high as 59%, and the vast majority of them are young people between the ages of 20 and 35!"

"what does that mean?!"

"This means that nearly 60% of leukemia patients cannot control their disease through medication. Their only way to survive is to undergo bone marrow stem cell transplantation immediately after chemotherapy!"

Having said that, Wei Tian paused again.

This time he paused longer, for more than ten seconds before he continued:
"But... everyone is well aware of the risks of bone marrow transplantation. Not only is there a high cost, but there are also huge risks of postoperative infection and rejection!"

“The most unacceptable thing is that due to the high malignancy of ‘acute myeloid leukemia’, the relapse rate after even ‘sibling-matched’ (siblings = brothers and sisters) transplantation is as high as 20% to 30%;

The relapse rate after haploidentical transplantation (the chromosome leukocyte antigen genes are exactly the same, parent and child) is even higher, reaching 30%~40%! "

"That is to say, even if these nearly 30% of leukemia patients undergo bone marrow stem cell transplantation, 40-% of them will eventually face death and there is no cure."

Wei Tian's deep voice echoed in the conference room.

The recurrence rate of 30 to 40% was a bit frightening for the top drug researchers present who were used to seeing all kinds of difficult and complicated diseases.

In fact, the data that 59% of "acute myeloid leukemia" patients could not be controlled by drugs was somewhat surprising, but it was unexpected that the recurrence rate among this 59% was as high as 30~40%.

Isn't this going to kill people?
At this moment, Wei Tian's voice sounded again.

"But fortunately, after decades of research, the medical community has conducted in-depth studies on the pathogenesis and related targets of 'acute myeloid leukemia'!"

"Our Qingshan Pharmaceutical Project Team No. 1 stood on the shoulders of countless giants in the medical field, invested huge sums of money, and after nearly seven years of continuous research, we finally found a target that is extremely sensitive to leukemia cells!"

"Once we fully understand the detailed mechanism of action of this target, and once we can further purify and screen the effective compounds we currently have, I believe we will be able to completely cure acute myeloid leukemia through this target!"

"And this is also the fundamental purpose of why I specially selected all the outstanding people from various project teams and convened a meeting here today!"

"Now!"

"The first project team has reached the most critical time to develop a drug that can cure 'Acute Myeloid Leukemia'!"

"Now, my colleagues in the first team need your support!

Now, the golden signboard of Qingshan Pharmaceutical needs your joint defense!

Now, countless patients with acute leukemia are waiting for us to save them! "

"Everyone, for the next three months, can you all work together to give it your all?! Fight your way out of this siege!"

"can!"

As soon as the words fell, the emotions of all the researchers present were instantly ignited, and everyone answered in unison.

"it is good!"

Wei Tian finally showed a smile on his face.

To be honest, it is very common to draw core members from various project teams to tackle a drug.

After all, even world-renowned R&D pharmaceutical companies like Pfizer and Gilead all adopt a wide-net model, and there are often several or even dozens of drug R&D projects within the company at the same time.

Initially, resources were basically divided equally among the projects. Only after a project had actually made progress would the company gradually allocate more manpower and financial resources to research and development projects that were likely to produce results.

Of course, although this is the case, the logic is also true.

However, the R&D backbones transferred this time were all the elites among the elites of each project team, which directly led to the suspension of the projects that were originally carried out normally in multiple project teams. The leading doctors of each project team all complained.

Therefore, the most important thing at the moment is to unify our thoughts and work together.

Thinking of this, Wei Tian couldn't help but feel quite emotional.

I have to say that the First Project Team really worked hard this time. Six and a half years is neither long nor short, and after experiencing countless failures, they actually made a breakthrough!

You know, the drug developed this time to treat "acute leukemia" is not like the previous male contraceptives. Once it can be developed and marketed, it will be a truly epoch-making drug!

Qingshan Pharmaceutical and all members involved in the research and development will be recorded in history and remembered!

How could this not make him excited?
"Okay, since everyone has no questions, then I would like to invite the project leader of our first project team, who is also the leader of the 'acute leukemia' drug research and development, Zhou Qingsong Zhou Bo, to say a few words to everyone."

There was sudden applause in the conference room.

After a moment, Dr. Zhou, as Wei Tian called him, slowly stood up from the first row and walked towards the stage under the gaze of everyone. He smiled and said:

"Actually, there's not much to say."

“Although your main research and development direction is not blood diseases, your expertise in the field of drug development is unquestionable.”

"Next, we will describe the R&D projects that require your assistance in documents. I believe that with your professional abilities, you will be able to get started quickly."

"I would like to thank you all first. I hope we can achieve greater results this time!"

"By the way, my assistant will arrange your groups. If you have any special requirements or areas of expertise, please let my assistant know now. We will notify you of the final groups by phone tonight at the latest."

"Well, that's it!"

As soon as he finished speaking, applause broke out again in the conference room.

At this time, Dr. Zhou's assistant also stood up and began to introduce the situation of the first project team to the researchers, while also starting to register the projects that each researcher was good at.

Seeing the enthusiasm of the researchers who were selected, Wei Tian and Dr. Zhou on the stage smiled at each other and gradually left the stage to the assistants.

The two of them walked quietly to the door of the conference room. The noise in their ears was no longer so noisy. Dr. Zhou stopped first, looked at Wei Tian and said with a smile:
"Director Wei, I'm afraid you haven't told Mr. Zhang about the transfer of so many R&D backbones? Do you think we should still tell Mr. Zhang?"

When Wei Tian heard this, he immediately smiled and waved his hands:
"We won't need to worry about this for now, Zhou Bo. You know that Mr. Zhang has been busy with Chinese medicinal materials recently. Should we not bother him with this?"

"Uh... that's fine."

As they spoke, the two looked at each other again and smiled knowingly.

Dr. Zhou certainly knew what Wei Tian was thinking.

Although there have been major breakthroughs in drugs for the treatment of acute leukemia, there is still some distance before they can be truly implemented.

Wei Tian certainly hopes to wait until it is truly transformed into a result that can be shown off before telling Zhang Yang and giving Zhang Yang a surprise.

Of course, Wei Tian also guessed Zhou Bo's inner thoughts.

Although the first project team, under the leadership of Dr. Zhou, has developed drugs such as male contraceptives, those drugs are ultimately not up to standard. The fame and influence they have brought to Qingshan Pharmaceutical are by no means comparable to those of the "leukemia" drugs.

Dr. Zhou naturally also hopes that Mr. Zhang will not be involved for the time being, and that he will independently lead the team to complete the research and development of the project.

This is not entirely because Dr. Zhou is narrow-minded.

The main reason is that Zhang Yang’s fame is too great and the pressure is too strong. Once he intervenes in this project, it may disrupt the progress of the entire project!
"Come on, Zhou Bo, come sit in my office for a while. I want to discuss some issues with you about this project!"

"it is good!"

The two of them pushed open the door of the conference room while chatting and laughing, but as soon as they took a step, Wei Tian was suddenly stunned.

I saw Mr. Zhang Yang appear at the door of the conference room at some point.

"Wei Tian, ​​Dr. Zhou, what did you two just say?"

"No...I didn't say anything!"

Wei Tianxia denied it subconsciously, and fortunately Zhang Yang did not continue to ask about it.

He just called the front desk of the R&D center and learned that Wei Tian had gathered most of the backbones to prepare for the final sprint of a drug. He simply came directly to the R&D center to understand the specific situation.

When I learned that the meeting was being held in the conference room, I just arrived at the door and ran into Wei Tian and Dr. Zhou pushing the door open.

Seeing Wei Tian at this time, Zhang Yang simply asked directly:
"Wei Tian, ​​I called your cell phone just now and found out that you have called a meeting of the backbones of various projects to prepare for the sprint to develop a drug. What drug is it? What's the situation?"

When Wei Tian heard this, he subconsciously glanced at Dr. Zhou next to him, and suddenly thought of the conversation they had just had.

After a moment, he hurriedly shook his head and said:

"Boss, no...no medicine, just an ordinary medicine."

"Ordinary medicine?"

Zhang Yang was even more confused. He looked through the gap in the conference room door and could see dozens of senior R&D personnel inside, including some researchers he was quite familiar with.

After a moment, he smiled and said:
"Wei Tian, ​​you don't think I don't have other channels to know, right? If you don't tell me, then I'll go ask my little sister directly."

"You don't think my little sister won't tell me, do you?"

Upon hearing this, Wei Tian suddenly became completely stunned.

He originally wanted to give Zhang Yang a surprise, but he didn't expect to forget about Zhou Xiaomei!
"That's all."

Wei Tian had a sad face:
"Boss, I originally wanted to give you a surprise and tell you when the final result is out, but I forgot that you have a little sister working undercover!"

"Well, to be honest, under the leadership of Dr. Zhou, the first project team has made a breakthrough in the treatment of 'acute myeloid leukemia'!"

"We have already found several key targets, and we have also found effective high-molecular compounds that respond well to the targets!"

"According to the experimental data we have now, the high-molecular-weight effective compound can inhibit at least 60% of 'leukemia cells'!"

"That is to say, even with the current situation, we have a high probability of developing a drug that can control 'acute myeloid leukemia'. The worst-case scenario is that it can significantly improve the survival of current leukemia patients!"

"but!"

"In addition, among the thousands of experimental data, we accidentally found that the 'leukemia cells' in two experiments were all killed, while other normal cells did not cause any damage!"

"It's just that we don't know which specific target or active ingredient causes this condition, so!"

"This time, I simply called together all the R&D backbones in the R&D center to prepare for a full sprint, because the ultimate effect that Dr. Zhou and I want is not to control 'acute myeloid leukemia', but to completely cure it!"

cure!

Acute myeloid leukemia? !

Zhang Yang’s eyes widened, and he suddenly became excited!
(End of this chapter)