After being fired, I became the light of medicine

Chapter 189 Amazing discovery!
Zhang Yang is already familiar with the simulator.

After locking the office door, he entered the simulator.

I opened my eyes and looked around, and a familiar feeling suddenly came over me.

The bright laboratory, with all kinds of high-end and sophisticated biological instruments, took Zhang Yang only two seconds to react. This was the Norwegian "Adrev Biological Laboratory" where the "Biological Laboratory" in the first phase of the simulated plot was located.

“I didn’t expect that the plot scene of the second stage would still be here.”

"That's good. I don't have to familiarize myself with the scene."

He couldn't help but sigh in his heart, then turned his head slightly, and a familiar yet unfamiliar figure appeared in his sight at the next workstation.

It's Evans.

In the previous plot "Biology Lab", Evans had a very good relationship with him.

He was responsible for compiling data on lung adenocarcinoma in Western European populations, while Evans was responsible for compiling data on East Asian populations.

Just as Zhang Yang was thinking about how to talk to Evans, Evans suddenly turned around, looked at Zhang Yang in surprise, and said:

"Zhang, what's wrong with you? Why do I feel like you're acting weird?"

The voice echoed in the laboratory, and the familiar feeling suddenly returned.

Zhang Yang remembered every detail of his encounter with Evans in the previous episode, and couldn't help but grin:
"Hello, Evans, long time no see!"

"Long time no see? Zhang, you're not suffering from amnesia again, are you?"

"I was really scared the last time you grabbed my collar and asked me where I was. Please don't play pranks on me again. I don't want to happen again."

"what?"

Zhang Yang opened his mouth slightly and reacted instantly.

Evans actually remembered that at the beginning of the last episode, he grabbed his collar and asked him what was going on.

In other words, the plot of the second phase not only continues the scenes of the previous plot, but even the memories of the characters in the plot are preserved?

It seems that this is really a continuous plot!
"Haha, Evans, I won't hurt you."

"But believe me, we haven't seen each other for a long time."

"What the hell!"

Evans shook his head helplessly. He seemed to have gotten used to Zhang Yang's tone:
"Zhang, stop talking nonsense and start working quickly. This mission is much more complicated than the previous ones."

Work?

Zhang Yang perked up immediately. In the previous plot, he completed the task and received the reward after collecting data on 1.6 patients with lung adenocarcinoma of the Nordic race.

Will I be able to complete the task through work this time as well?
He almost blurted out:

"Evans, what is my job this time?!"

"Oh, My God."

Evans thought Zhang Yang was joking with him, and spread his hands with a wry smile:

"Zhang, please stop playing pranks like this, okay?"

"Well, I really lost to you..."

"Dr. Eric just assigned a new task yesterday. We received a request for help from the British company AstraZeneca. Their new drug, Osimertinib, which is currently undergoing phase III clinical trials, has encountered some problems..."

"To be precise, it's not that something went wrong, but during the Phase III clinical trial, they discovered that the latest 'lung adenocarcinoma cells' contained a specific protein fragment that had never been discovered before!"

"So, they put their Phase III clinical trial on hold, hoping that we could help them figure out the interaction between the protein structure of this specific protein and the cancer cell receptor, as well as the pathway between the specific protein and the cells as soon as possible."

Osimertinib? !
Phase III clinical trial? !
Zhang Yang was slightly stunned.
Osimertinib is a targeted lung cancer drug launched by AstraZeneca at the end of 2019. Once launched, it was hailed as the most powerful "miracle drug for lung cancer."

The time for the current simulation plot is 2018, and the timing is exactly right!
Could it be that this mission is related to AstraZeneca’s top third-generation targeted drug “Osimertinib”?
Is it to let myself participate in the research and development of "Osimertinib"?
Zhang Yang was a little distracted, but soon his attention shifted from "osimertinib" to the last sentence Evans said.

Because a new specific protease was discovered on the latest 'lung adenocarcinoma cells', the Phase III clinical trial of "osimertinib" was suspended?

If this statement is said to a layman, it may seem normal. After all, with new discoveries, clinical trials should naturally be suspended.

But Zhang Yang is the boss of Qingshan Pharmaceutical, he knows it very well!

When an innovative drug reaches Phase III clinical trials, it means that it has entered the final sprint stage for market launch, and its main ingredients and target mechanisms have also been basically determined!

At this time, even if there are new discoveries, we just need to put them into the research and development of the next generation of drugs, and there is no way to stop!
This is totally against common sense!

unless!

Zhang Yang was stunned, unless the benefits brought by this discovery were unimaginable!

hiss!
The huge doubts shocked Zhang Yang's heart, and countless information flooded into his mind.

"Osimertinib" is known as the "miracle drug for lung cancer", and once it was launched on the market, it became the world's most profitable targeted drug for lung cancer, with annual sales of up to 50 billion US dollars!
Could it be that the reason why Osimertinib is so effective in reality is because of this discovery?
Zhang Yang's expression became completely serious, and he suddenly became very interested in the new specific protein mentioned by Evans!
At this moment, Evans saw that Zhang Yang was getting serious, so he stood up and walked to the computer where Zhang Yang was, and skillfully helped to open a work document.

"Zhang! This is the specific work content. It's all in your work document."

"AstraZeneca has temporarily named this newly discovered specific protein 'T14 protein'. What you need to do is to hurry up and analyze how the pathways between 'T14 protein' and normal cells and cancer cells are connected. Now AstraZeneca is eager to know their internal connections."

"As for protein structure analysis and other analyses, don't worry about them. Other colleagues are doing them."

Zhang Yang nodded. This should be the task to be completed in this simulation plot.

After a moment, he looked at Evans with gratitude.

I have to say that Evans has a really good temper and has a very good relationship with me. Even if he thinks I am joking, he always explains patiently.

"Thank you Evans, I understand now."

"But what about you? What is your mission this time? Are you also studying T14 protein?"

"Uh……"

After he finished speaking, Zhang Yang didn't expect Evans to suddenly stop without any warning, and was somewhat unnaturally stunned for a moment.

"Me? I don't study T14 protein. Dr. Eric assigned me other work last night."

Zhang Yang obviously noticed Evans's abnormality, thought for a moment, and said:

"Other work?"

"Evans, can you tell me what the mission is? I'm curious."

After a brief pause, Evans returned to normal. He smiled bitterly and shook his head, then suddenly lowered his voice:
"Zhang, I'm sorry, I can't tell you. Dr. Eric specifically reminded me that it must be kept confidential."

"Besides, I don't want you to know about this. Believe me, it won't do you any good if you know it!"

After he finished speaking, Zhang Yang looked at Evans deeply, his expression somewhat unpredictable.

Fortunately, after a moment, he suddenly exhaled heavily:

"Okay, then I won't ask." "Yeah!"

Evans was visibly relieved, and a smile reappeared on his face:

"Zhang, you should start working quickly. I also want to get ready to go to work!"

"By the way, I will be in another lab during this time, but I will come here to clock in every morning."

"Ah."

After saying that, Evans returned to his seat, picked up the 14-inch notebook on the table, said goodbye to Zhang Yang and left.

After Evans left, although Zhang Yang was very curious about the "confidential" work that Evans suddenly mentioned, the most important task at the moment was to complete the plot mission quickly and get the plot reward!
Thinking of this,

Zhang Yang looked at the computer screen and began to read the work documents carefully.

After about ten minutes, he had read the entire work document and his work ideas became clearer.

At this moment, he suddenly found that a light blue screen had appeared in the upper right corner of his body, which actually displayed the progress of the task.

Task content:

Analysis of T14 protein cell pathway, current progress: 0%.

“It’s pretty smart.”

After sighing, Zhang Yang stood up from his chair and walked towards the experimental area.

He needed to first take out a piece of "lung adenocarcinoma" tissue, and then use sophisticated biological instruments to find and analyze the lung adenocarcinoma "T14 protein" mentioned in the work documents, and finally figure out its internal pathways.

Zhang Yang soon became immersed in the research of "T14 protein".

It has to be said that although his main major is drug research and development, he has a good professional foundation and has some research on cellular proteins. This job is difficult for him but he can still accept it.

So in the next few days, Zhang Yang not only did not feel any difficulty, but he made rapid progress while cramming knowledge related to specific proteins.

Simultaneously,

He also confirmed that the plot of the second phase would be the same as the first phase. He would just clock in at work every day and only need to complete the daily workload, and he could even work overtime to complete it.

About 20 days later, Zhang Yang's understanding of specific proteins had reached a new level. With the addition of three more assistants from the laboratory to assist in the analysis, the analysis progress of "T14 protein" on the task bar reached 30%.

but.

Just as Zhang Yang was fully devoted to the analysis of the "T14 protein pathway", he also noticed that Evans was just as he said. He could be seen checking in almost every morning and then disappeared for the whole day.

Zhang Yang thought of what Evans had said before - the work assignment needed to be kept confidential.

For a biological laboratory, there are indeed some experimental tasks that need to be kept strictly confidential.

For example, when cooperating with certain pharmaceutical companies to develop a drug, any commercial secrets involved naturally need to be kept confidential.

For example, when developing an important patent result, strict confidentiality is also required. At least, the fewer people who know about it, the better before the patent result is fully confirmed.

I just don't know why Evans wants to keep it secret or what work tasks need to be kept secret.

So curious!

After fruitless thinking, Zhang Yang simply stopped worrying about it and continued to focus on the analysis of "T14 protein".

One month later, the analysis progress of "T14 Protein" on the task bar reached 60%.

Evans was also nowhere to be seen all day. He came in every morning with a laptop, clocked in, and left with the laptop again. This repeated every day for a month.

Zhang Yang has become completely accustomed to this kind of simulation work. Although he is occasionally curious about what work Evans is doing, the most important thing at the moment is to complete the progress of the "T14 Protein" task on the task bar as soon as possible.

And within this one month.

While Zhang Yang was completing the analysis of "T14 protein" in the simulator, he was also dealing with various things in reality.

Due to the unique functions of the "nodule imaging CT machine", after the news spread overseas, Samsung Bio took the lead in reaching a purchasing agreement with Elephant Medical.

Samsung Biologics has several Samsung hospitals under its umbrella, the most famous of which is Samsung Seoul Hospital. Samsung Biologics purchased 10 "nodule imaging CT" at one time in the name of "Samsung Hospital" and also introduced the matching "nano nodule contrast agent".

Just like Zhang Yang said, you can buy it, but you have to pay extra.

Mao Zhiqiang was also ruthless. The "nodule imaging CT machine" introduced by Samsung Biopharma cost up to 230 million US dollars per unit, which is equivalent to 1600 million yuan!

This is twice the price in China!

The "nano-nodule developer" costs 200 yuan per tube in China, and the price after introduction from South Korea has reached 350 yuan per tube, nearly twice as expensive.

In addition, Zhang Yang also received shocking news.

Siemens, far away in Germany, seems to have contacted the Adrev Biological Laboratory, and the two sides reached a cooperation agreement to develop a developer of the same type as the "nano-nodule developer".

After seeing this news, Zhang Yang was a little dazed and didn't know whether to laugh or cry.

At this moment, he was in the simulator, analyzing T14 protein in the Adrev Biological Laboratory. Unexpectedly, in reality, the "Adrev Biological Laboratory" actually began to cooperate with Siemens to develop developers.

But I don’t know if a similar developer can be developed.

Zhang Yang did not worry for too long. As he continued to analyze the "T14-specific protein" pathway in the simulator, his attention was once again drawn back to the T14 protein.

60%，

70%，

80%...

Zhang Yang's research and development speed is getting faster and faster, from the study of T14 protein on cancer cell pathway signals to the study of T14 protein's association with normal cells...

Gradually, more and more pathway analysis data of "T14-specific proteins" were completely recorded!

Gradually, the pathway mechanism of "T14-specific protein" has also been studied clearly!

Analysis data showed that the most important function of "T14-specific protein" in cells is to fuse with key signaling molecules in cells and activate the PI3K-Akt pathway, thereby interfering with normal cells and inducing cancer cells!
But what surprised Zhang Yang was!
Logically speaking, since the mechanism of T14 protein is to interfere with the proliferation of normal cells and thus induce normal cells to become cancer cells, then T14 protein should be effective on all cells.

But there is another set of data showing that the T14 protein seems to be effective only on certain host cells and is not sensitive to other experimental host cells!
Zhang Yang was puzzled.

At this moment, he suddenly thought of the shocking hypothesis he had made when he learned about "lung adenocarcinoma" before.

If the pneumonia virus increases the incidence of "lung adenocarcinoma", then why is there no significant increase in European and American populations, while the Asian race has increased by 10%!

Could it be a racial issue?!
Zhang Yang's eyes froze.

Could it be that the T14 protein is only sensitive to cells of East Asians? And not sensitive to cells of Europeans and Americans?!

But before Zhang Yang could verify it, an even more shocking idea suddenly popped into his mind.

Where does this T14 protein come from?

(End of this chapter)