After being fired, I became the light of medicine

Chapter 148 Buying out the BI-Toxin Catalyst Patent! (Subscription Request)

On the other side, Qingshan Pharmaceutical’s drug research and development center.

Since Zhang Yang's "two tasks" were determined, Fang Hanliang and the newly established R&D project team have devoted themselves to the imitation of the "BI-toxin filtration catalyst".

Fang Hanliang knew very well that Zhang Yang attached great importance to BI's "Toxin Catalyst", and he also understood that his current priority was to quickly find out whether the "catalyst" was effective when used in combination with "Kidney Toxin Clearing"!

If so, how much can the toxin filtering effect be improved? !
The data results he provided will also determine what method Qingshan Pharmaceutical, or Zhang Yang, will take and what price he will pay to obtain the patent authorization for the "BI-toxin filtering catalyst".

However, it is not easy to imitate the "BI-Toxin Filter Catalyst".
Fortunately, Fang Hanliang had nearly 15 years of work experience in BI companies, and he more or less knew some of the company's R&D ideas. In addition, the imitated "catalyst" was not intended for commercial use, but only for scientific research, so some details could be similar.

But even so, it still took more than 4 months to barely get a similar "catalyst", and then more than 3 months of extensive experiments and data analysis. It was not until today that we finally completed the data summary and obtained confirmable data.

"Mr. Zhang, after more than three months of experimental data, we have confirmed that BI's 'Catalyst' and our 'Kidney Toxin Clearing' are fully compatible and can achieve combined treatment!"

"Our data on mice and monkeys show that the toxin filtration rate of the combined drug is 4.3% higher than that of the 'Kidney Toxin Clearing Dialysis Needle' alone, and this is the level of our generic drug."

"If it is their original research drug, and then further purification and improvement, I believe it is possible to approach or achieve the 7% originally announced by BI."

After getting the positive data, Zhang Yang breathed a sigh of relief. After half a year of waiting, he finally got the result.

Then next,
He will try every possible means and at any cost to obtain the patent authorization of BI's "toxin filtering catalyst"!

Only by obtaining the patent authorization for the "catalyst" can he develop an injectable catalyst for use with Kidney Toxin Clearer!
Once the combination of drugs can really increase the toxin clearance rate to 85% or even above 87%, it is entirely possible to reduce the current need for dialysis after two injections to once every two weeks!

It may even be possible to get off dialysis altogether!

If this step can be truly achieved, it will undoubtedly be a huge benefit to all dialysis patients!
and,

Thanks to the efforts of clinical doctors, "Shenduqing" has now begun to be used in patients with "stage 4 kidney disease".

If the toxin clearance rate can be improved, it may be possible to develop a "long-acting kidney toxin clearing dialysis injection" in the future, changing the current injection every two days to one injection for a week or one injection for half a month!

but,

After a brief imagination, Zhang Yang came back to his senses and suddenly remembered the first problem encountered when "BI-Catalyst" was first tested in the clinical phase I.

"Fang Bo, when they were doing the first phase of clinical trials, the clinical effect was only about 2.5%. Do you know the reason now?"

"Yeah, I already know."

"To put it simply, the blood passes through the dialysis machine for too short a time, and the fusion time with the catalyst is not enough, so the large molecular toxins cannot be completely decomposed, so the effect is poor."

"But this is not a problem for us. Our 'Kidney Toxin Clearing' drug starts to clear toxins one hour after injection."

Zhang Yang understood immediately after hearing this, and he smiled and said:
“That’s a perfect match.”

While the two were talking, Zhou Xiaomei in the laboratory also brought a glass of water and handed it to Zhang Yang.

"Mr. Zhang, please drink some water."

"Oh well."

Over the past six months, Zhang Yang has always paid attention to the progress of "Catalyst", and the two have had more and more contact.

Seeing Zhang Yang taking the paper cup, Zhou Xiaomei smiled and went back to her own business.

Fang Hanliang showed a smile, his eyes fell on Zhang Yang again, and he returned to the topic.

"Mr. Zhang, now that we have confirmed the data, what are your plans next?"

"I do have some personal connections at BI. Do you want me to help you get a feel for what they are saying?"

Zhang Yang frowned slightly.

Now the role of the "catalyst" has been confirmed, but from the last contact with BI, BI has little interest in selling patents.

I'm afraid this will cost a lot!
As for his claim that he is conducting research on "macromolecular toxin catalysts", that is just an empty plan, and BI company may not believe it or not!
"Fang Bo..."

Zhang Yang was about to speak, but at this moment, the phone in his pocket suddenly rang with two consecutive message alert sounds.

He was slightly stunned. This message alert tone was neither WeChat nor text message. Two seconds later, he realized that it was WhatsApp, a very popular social software on the Internet.

It was a message from Hans, the vice president of BI.

"Zhang, are you there?"

Looking at the content of the message, Zhang Yang's originally frowned brows suddenly relaxed.

Fang Hanliang on the side also noticed the change in Zhang Yang's expression. When he saw the content on the phone screen clearly, he was surprised at first, and then he couldn't help but smile.

"Boss Zhang, it seems that Hans and his team have encountered some problems!"

Zhang Yang exhaled slightly. There is an old saying in China that goes "One does not visit a temple for no reason!"
After waiting for a minute, he replied:

"I'm here Hans, what's wrong?"

"Oh, I'm so happy to hear from you so quickly."

"I saw your company announce that it is developing a 'macromolecule toxin catalyst'. I haven't seen any updates on your research and development for a long time. How is the progress recently?"

After seeing these words, Zhang Yang basically knew that Hans contacted him for something!
It is most likely BI’s “toxin filtering catalyst”!
He replied calmly:
"We are making good progress and will soon start Phase I clinical trials. President Hans, I also often follow your 'BI-Catalyst'. Your progress is much faster than ours!"

"The Phase I clinical trial is about to begin? So soon?"

Hans did not answer Zhang Yang's last question, and his attention was obviously on the Phase I clinical trial.

Zhang Yang couldn't help but smile and said quickly:

"It's fine. By the way, Hans, is there anything important?"

This time, it took two minutes before Hans replied again:

"Okay, Zhang, I suddenly remembered that you were interested in our 'BI-Catalyst' half a year ago?"

"I contacted you today to ask if you are still interested?"

Still interested?
Seeing these words, Zhang Yang's heart couldn't help but beat rapidly twice, and Fang Hanliang's eyes flashed with a hint of surprise!
After a moment, Zhang Yang took a deep breath and slowly replied:

"Hans, to be honest, I'm not very interested. You know, we are already developing our own 'macromolecule toxin catalyst' and we have invested a lot of money in it."

At the end, he suddenly added:
"What's wrong? Are you trying to sell the patent?"

Seeing the message being sent, even Zhang Yang couldn't help but feel a little excited.

He stared at the screen of his mobile phone. As long as Hans showed a little intention to sell, he would be able to take the initiative and know the bottom line of BI. Just as Zhang Yang was looking forward to it, Hans, who was sitting in the conference room, handed the phone in his hand to President Dussmann who was standing in front of him.

It turned out that after the BI company decided to contact Tsingshan Pharmaceutical, Hans volunteered to use his personal relationship to sound out Tsingshan Pharmaceutical's attitude first.

Looking at the news in front of him, he said:

"Mr. President, how do we respond? Should we respond directly now?"

Dusman frowned and shook his head slowly.

"Wait a minute, let's talk for a few minutes!"

“Although they say they are not interested, no one can be sure whether they are interested or not!”

"We must find a way to find out their true cards. This is crucial for us. Only by figuring out their true thoughts can we take the initiative in the subsequent negotiations!"

Hans nodded but didn't respond directly.

Everyone knew that if Zhang Yang was interested, he would surely ask further questions.

And those who are not really interested may already be busy with other things.

One minute, two minutes, five minutes.

Zhang Yang was also a little anxious.

We were having a good chat, why did it suddenly go haywire over the most crucial issue?
Didn’t you see it?!

After a while,
He began to type a text in the chat box:
"Hans, are you still there?"

But after typing the last letter, he suddenly realized that this might be a test from the other party? !
Thinking of this, he suddenly came to his senses. The growth over the years has made him no longer the flamboyant person he used to be.

He was waiting for news from Hans, and Hans was also waiting for news from him!
Hans is not clear about his own cards, and is not sure whether he is interested or not. Whoever can't help but send a message first will be put in a passive position!

The testing between the two sides actually started from the first message!

Calming down, Zhang Yang simply put his phone back into his bag, said goodbye to Fang Hanliang and returned to the office.

As soon as I stepped into the office, news about Hans appeared again.

"Zhang, I was just processing a document and was delayed for a while. Sorry."

“We do have the idea of ​​doing a BD transaction now, and we are also willing to do patent licensing as you mentioned before.”

"Do you want to know more?"

Zhang Yang raised a smile. He no longer had to pretend to wait and sent messages at a normal speed:

"If you do have plans for a BD transaction, I can find out about it."

"Do you have a plan? How about this, you send me your plan and I'll take a look."

But before Zhang Yang could be happy for even a second, new news came from the other side of the screen:
“We haven’t developed a complete BD plan yet, but we have a simple framework in mind.”

"We can license the patent of 'BI-Catalyst' to you for $3 million, but we need to get 30% of the profit dividends of all new drugs developed based on this patent."

30% profit dividend?
Zhang Yang frowned, this dividend was a bit high.

……

According to his idea, the price of "Kidney Toxin Clearing Dialysis Replacement Injection" is 1000 yuan per injection.

The injectable "large molecule toxin catalyst" is a combination drug and an accessory product. The price is about 300-400 yuan, and the profit should be 200-300 yuan.

Based on the profit of 300 yuan per injection and domestic sales of 500 million injections per year, the domestic profit is 15 billion yuan per year, and the amount distributed to BI company is as high as 4.5 million yuan.

This is still domestic profit.

Profits are higher and sales are greater overseas. According to the market share of global hemodialysis, profits overseas can reach at least 35 billion, which means 15 billion in profits must be paid to BI company every year!

150 billion in ten years,
300 billion in years!
He didn't like this approach.

Soon, he called the finance manager, Lao Qian.

"Old Qian, come to my office."

Five minutes later, Financial Director Lao Qian rushed to Zhang Yang's office.

Zhang Yang didn't waste any words, his first sentence was:
"Old Qian, how much cash do we have in our account right now?"

"cash?"

Old Qian was stunned for a moment, then his eyes gradually became excited.

Ever since the last time the Medical Insurance Bureau purchased 2000 million bottles of "Abrocitinib", the company's cash flow suddenly soared to 122.5 billion and has never dropped since!
He has reminded Mr. Zhang more than once that he can buy some financial products or government bonds, but Mr. Zhang seems not interested at all!
You know, as a professional financial staff, he wants to cry every day when he sees the 10 or 20 billion in cash in the company's account lying in the bank account earning a meager current interest!
Could it be!

Mr. Zhang finally got it?

Are you finally going to buy financial products?

"Mr. Zhang, we have invested billions in new drug research and development during this period, and we only have 231.6 billion in cash in our account!"

"If you want to buy financial products, you can buy 200 billion! The remaining 31 billion is enough for working capital!"

"Buy financial products?"

Zhang Yang shook his head and calculated silently in his mind.

"231.6 billion is only 33 billion U.S. dollars."

"To be honest, 33 billion is not a lot in BD transactions that are often worth more than billion or billion US dollars!"

"But it should be enough to buy out the 'BI-Toxin Catalyst'!"

Zhang Yang clenched his fists.

"enough!"

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(End of this chapter)