After being fired, I became the light of medicine

Chapter 137 This medicine has some effect (Please subscribe!)
Dr. William was one of the doctors who attended the "Kidney Disease Summit" and was quite familiar with Qingshan Pharmaceutical's "Kidney Toxin Clearing Dialysis Replacement Needle".

So, when Novartis contacted the Mayo Clinic to prepare for clinical trials, he immediately noticed the "dialysis needle" and took the initiative to recommend it to patients.

Seeing Professor Stephen's slightly surprised expression, he nodded and explained:

"The efficiency of Qingshan Pharmaceutical is indeed amazing, but I think this is mainly because this 'dialysis needle' is not only undergoing clinical trials in our country, but also in India."

"The number of samples and clinical data they will receive will be very large, which will undoubtedly provide them with a lot of data references."

Professor Stephen recovered and breathed a sigh of relief:

"I also work in scientific research, although not in the field of biopharmaceuticals, but a large amount of data does have a positive impact on the research and development process..."

"I can understand!"

"That's good."

Doctor William smiled slightly:
"Then would you like to try this 'Kidney Toxin Clearing Dialysis Needle'?"

"Now that the toxin removal rate has reached 70%, because it is an 'instant removal' mechanism, the toxins remaining in the body after 12 hours are actually less than those after dialysis; after comprehensive calculation, the toxins remaining in the patient's body within 48 hours are only slightly more than those after dialysis..."

"It can be said that the risk is much smaller than before."

"Don't you want to experience the feeling of urinating again? Don't you want to go to the football game and travel again?"

"Try the 'Kidney Toxin Clearing Dialysis Injection'. It will definitely meet your needs."

Stephen was moved.

For the first time, his eyes fell on the promotional brochure of Qingshan Pharmaceutical's "Kidney Toxin Clearing Dialysis Needle".

As a university professor, Dr. William quickly realized the advantages of the "Kidney Toxin Clearing Dialysis Needle" over dialysis without much explanation.

Although the effective clearance rate of 70% is lower than that of dialysis, it is better in terms of “instant clearance” and can replace dialysis with just one injection!

Just one minute later, he looked bitter:
"Doctor William, I believe you, so I will try it with all my might. You should know that this is my first time using a drug from China, and also my first time conducting a clinical trial."

"I hope my choice is not wrong and it can bring me a better life."

"Haha, don't worry, there is already a lot of clinical data to prove that it can work!"

Stephen, a professor of semiconductors at the University of Minnesota, became one of the subjects in the Phase II clinical trial of the "Kidney Toxin Replacement Injection".

In fact, Professor Stephen is not an isolated case.

In the United States, influenced by liberalism and multiculturalism, Americans value freedom more and like to travel and take risks, but dialysis has completely turned them into "puppets" and made them completely tied to the dialysis machines.

Therefore,
Even though Novartis indicated at the beginning that the "Kidney Toxin Clearing Dialysis Injection" was a drug from China Qingshan Pharmaceutical, countless American dialysis patients still "reluctantly" accepted it.

Novartis' Phase II clinical trial recruitment is progressing smoothly.

On the other side of the ocean, the Phase I and Phase II clinical trials led by GlaxoSmithKline in India were also quickly passed, and recruitment for Phase III clinical trials has now begun.

At eight o'clock in the morning, Lucas arrived at the clinical trial base in Delhi, India. At this time, dozens of patients were already waiting in line outside the base.

There have been rumors circulating on the Chinese Internet that India has achieved nationwide free medical care.

Indeed, taking dialysis as an example, the Indian government implemented a program called the "National Dialysis Program" a few years ago, under which patients at or below the poverty line can apply for dialysis free of charge.

The specific requirements are that the annual income is less than 10 rupees (approximately 8500 yuan) and the annual pension is less than 30 rupees. As long as you meet the conditions, you can apply for free dialysis at an officially designated specialist hospital.

However, there are still many problems.

For example, there is a plan, but there are not many specialized hospitals, and the dialysis equipment and conditions in the hospitals are relatively low, which will greatly affect the quality of dialysis.

In addition, for patients who do not meet the requirements for free dialysis, the cost of dialysis will be more expensive.

When GlaxoSmithKline conducted clinical trials of the "Kidney Toxin Clearing Dialysis Injection" in India, there was an endless stream of dialysis patients willing to participate because the drug and weekly dialysis were provided free of charge.

Looking at the long queue of Indians waiting to register for Phase III clinical trials outside the window, the assistant smiled:
"President Lucas, it looks like we will be able to recruit enough subjects soon. I have to say that India is a place where patients are recruited quickly."

"If it were in our country, it would take at least a year to recruit 450 people for the Phase III clinical trial."

Lucas also smiled. What the assistant didn't say was:

In India, not only is the number of patients large and the recruitment speed fast, but the recruitment cost is also pleasantly low.

Each of the 450 subjects only needed 15000 rupees to compete, which is less than $180 per person.

Compared to the thousands of US dollars per person in the local market, this is simply a bargain.

"David, I see that many of the people below are skinny. Please arrange for each person to receive a bottle of milk and a piece of bread each time they conduct an experiment, in order to avoid any accidents caused by low blood sugar."

"President Lucas, you are such a kind person."

……

Clinical trials of the "Kidney Toxin Clearing Dialysis Needle" in the United States and India are proceeding in an orderly manner. In particular, after Tsingshan Pharmaceutical continued to improve the effective toxin removal rate to 70%, it attracted the attention of more dialysis patients and even the medical community.

Gradually, more and more reports about "Kidney Toxin Clearing Dialysis Needle" appeared in relevant journals, magazines and self-media.

The news finally reached the country.

When the "Kidney Toxin Clearing Dialysis Needle" was first launched overseas for clinical trials, Tsingshan Pharmaceutical briefly disclosed the treatment effects and functions on its official website, and domestic patients were quite looking forward to it for a while.

Unexpectedly, for one, two, or three months, there was no news about clinical trials from Qingshan Pharmaceutical.

I originally thought that this "Kidney Toxin Clearing Dialysis Needle" had encountered some problems and had not yet been launched in clinical trials in China. It was not until the news was passed back to China that I realized the problem.

Wow, Qingshan Pharmaceutical’s “Kidney Toxin Replacement Injection” has not failed to undergo clinical trials, but has gone overseas to conduct trials first!

Excessive!

"I think Qingshan Pharmaceutical is too unfair. They tested such a good drug overseas first? And not domestically? That's too much!"

"That's right, it's like a bolt from the blue! I can still tolerate the United States, but the most infuriating thing is that there are clinical trials in India but not in China? Are we not even as good as India?"

"...I have been waiting for this drug for a long time! I saw many people on the Internet saying that the 'Kidney Toxin Clearing Dialysis Injection' is very effective and can restore urination immediately after injection. I am so envious that I am crying! Mr. Zhang, please start clinical trials in China as soon as possible!"

"Hey, this reminds me of the time when Huawei's Meta series was always first launched overseas. From a business perspective, the overseas prices of Qingshan Pharmaceutical's drugs are indeed much higher than those in China, and the profits are also greater. It is understandable that they value the overseas market...

It seems that they are planning to launch it overseas first, and then gradually launch it in China..."

"I feel so sad and want to cry! Qingshan Pharmaceutical has also slowly changed. Sigh."

When the news reached China, it immediately sparked discussion among a small number of dialysis patients.

However, due to the good reputation of Tsingshan Pharmaceutical and the recent clobazam incident which made everyone completely convinced of Tsingshan Pharmaceutical, the vast majority of patients still believe that Tsingshan Pharmaceutical will not discriminate against domestic patients for purely commercial interests.

"I think Qingshan Pharmaceutical should have its own considerations. Don't be too anxious. I suggest you wait and see!"

"That's right. Many of the drugs developed by Qingshan Pharmaceutical have always been the first to conduct clinical trials in China. This is the first time that clinical trials are conducted abroad. Although I don't know the specific reason, I still believe in Qingshan Pharmaceutical and their decision!"

"I also believe in Qingshan Pharmaceutical and Mr. Zhang. If that doesn't work, we can go to Qingshan Pharmaceutical's Weibo and ask. I heard that Qingshan Pharmaceutical's official Weibo will answer any questions you have."

"Okay, that's a good idea!"

Like many companies, Qingshan Pharmaceutical’s external publicity windows include Weibo and Douyin in addition to its official website. The person in charge of Qingshan Pharmaceutical’s Weibo is a girl born in the 00s from the Information Department. After noticing that many patients left messages on Weibo, she immediately came to the office to report the problem to Zhang Yang.

“Why not conduct clinical trials in China?”

Looking at the questions raised by fellow patients on Weibo, Zhang Yang was at a loss whether to laugh or cry.

When I worked so hard to get the "Kidney Toxin Clearing Dialysis Needle" to conduct clinical trials overseas first, wasn't it because I was worried that domestic patients would suffer organ damage due to side effects?
How do you answer now?

It can't be said that the previous 60% of "kidney detoxification dialysis needles" have the potential to cause irreversible damage to the human body, so they were tested overseas first, allowing the Americans and Indians to test the poison first, right?

But looking at the dozens of comments, he knew he couldn't not reply.

After thinking for a moment, he said slowly:

"Let me tell you this. Qingshan Pharmaceutical has not forgotten the domestic patients. The main reason why we are not conducting clinical trials in China is that the 'Kidney Toxin Removal Injection' is still in the research and development stage, and its toxin removal effect still has room for improvement!"

"In the next few months, once the drug is ready, we will arrange clinical trials in the country as soon as possible. Please be patient."

The timely response from Qingshan Pharmaceutical barely calmed the patients' doubts, and Zhang Yang couldn't help but wonder whether he should start the clinical trial of "Kidney Toxin Clearing Dialysis Needle" in China now.

After thinking about it, I decided to wait for the approval of the Phase II clinical trial in the United States. After the kidney toxicity clearance is improved to 80% complete, I will directly start the Phase III clinical trial in China. The time difference is not much.

Just as Zhang Yang began to prepare to upgrade "Kidney Toxin Clearing" to a complete product, the "catalyst" drug that had previously attracted Wei Tian's attention to BI Company also officially started the first phase of clinical trials.

BI is Germany's top kidney drug research and development company. The "catalyst" that impressed Zhang Yang at the "Kidney Summit" was mainly used to improve the toxin filtration rate of the dialysis machine.

The reason why Zhang Yang was interested in this was that he suddenly had the idea of ​​trying to see if this drug could be used in combination with Qingshan Pharmaceutical's "Kidney Toxin Clearing Dialysis Needle" to improve the toxin clearance rate.

Now this "catalyst" has been officially named "BI-toxin filtration catalyst" after the first phase of clinical trials.

Zhang Yang then told Wei Tian to pay close attention to the data of its Phase I clinical trial. If it was true that the toxin clearance rate could be increased by more than 7% as Hans from BI said, he wanted to discuss cooperation with BI.

Of course, there is no rush for this matter. We have to wait until the first round of BI company's Phase I clinical data is released before we can get a rough idea.

While Zhang Yang was dealing with these trivial matters, on the other side of the ocean, the Phase II clinical trial of "Kidney Toxin Clearing Dialysis Replacement Injection" that Novartis was recruiting for was completed.

3 month 16 day,
Professor Stephen received accurate notification that he had been successfully enrolled in the group and would officially start receiving the first injection of the "Kidney Toxin Clearing Dialysis Needle" two days later.

March 3, 18: am.

Professor Stephen arrived at the Mayo Clinic Medical Clinical Trials Center on time, and his attending physician William was already waiting for him there.

"Professor Stephen, don't be stressed. Believe me, this is definitely a good experiment."

"I hope so. I've read a lot of reports about Huaxia Qingshan Pharmaceutical these days. I really hope they can be as good as they are in the field of blood diseases."

"It's okay, don't worry, professor. It's your turn, second window. Go ahead. Good luck."

"Lend your auspicious words."

Professor Stephen walked quickly to the second window William mentioned, and saw a black female nurse.

"Mr. Stephen Howard?"

“Yes, here are my medical records and clinical trial registration card.”

"OK, wait."

The black female nurse quickly confirmed Stephen's identity and then returned all the information to the professor.

"Okay, Mr. Stephen, your identity has been confirmed."

As she spoke, the nurse's tone became formal and serious:
"Then I will confirm with you again. You are currently participating in the Phase II clinical trial of the 'Kidney Toxin Clearing Dialysis Replacement Needle' developed by Huaxia Qingshan Pharmaceutical Company and conducted by Novartis. Are you sure you want to participate?"

Stephen paused for two seconds and nodded:

"I am sure."

"Okay, let me tell you in detail about the entire clinical trial process."

"I will then give you your first injection of 'Kidney Toxin Clearing Dialysis Replacement Injection' through an IV, and you will urinate in about two hours."

"You will feel a slight pain in your urinary system, which is in your lower abdomen, but don't be afraid. This is the drug ingredients restarting your kidneys and telling the urinary system that it is about to work again."

"You can't leave the hospital within these two hours. You need to put all of your first urine into this bottle and bring it back to me."

"I will also draw your blood for the first time after taking the medicine at that time, do you understand?"

Stephen pouted as he looked at the disposable urinal in front of him, obviously not expecting it to be so troublesome.

"Okay, I got it, I'll get it back on time."

“Okay, great!”

The black female nurse smiled, revealing her white teeth.

However, as soon as she finished speaking, she took out two larger disposable urine containers in front of Professor Stephen's surprised look.

"The larger of these two containers is used to hold all the urine starting today, and the smaller one is used to hold all the urine tomorrow. Remember, all of it."

Professor Stephen immediately shook his head and complained:
"Why is it so troublesome..."

“How can it be called a clinical trial if it’s not troublesome?”

The black nurse shrugged.

"By the way, remember to pack all the urine separately. This is very important clinical data and will be very helpful for the subsequent improvement of drug ingredients!"

"After you collect your urine and bring it to me on the third morning, I will give you the second injection of the drug. Do you understand?"

Stephen nodded unhappily.

Seeing Stephen's expression, the black female nurse understood and said with a smile:

"Don't worry, there will be more requirements in the first two weeks, but in the third week, fourth week, and even the second and third month, you only need to collect clinical data once a week!"

"Okay, now I'm going to give you your first injection, Mr. Stephen."

Professor Stephen suddenly perked up and stretched out his right arm.

One minute later,
About 20 ml of transparent and colorless medicine was slowly injected into the body through the vein in the arm. Stephen did not feel any discomfort.

ten minutes later,

He began to feel a slight chill in his body.

About an hour and forty minutes later, he suddenly felt a dull pain in his lower abdomen, and then, the urge to urinate that had not been there for half a year suddenly surged into his brain.

Although he was mentally prepared, when the moment really came, he couldn't help but get goosebumps all over his body.

After more than half a year, the dormant kidneys actually started to urinate again!

hiss!
This medicine is working!

(End of this chapter)