After being fired, I became the light of medicine

Chapter 131: Generic Clobazam? No, I want the original drug (Subscription required)
About 20 minutes later, Zhang Yang was invited into the director's office.

After receiving the call, Director Song hurried back to the bureau from outside. This was also the first time he saw Zhang Yang in person.

It’s not that his rank is not high enough to know Zhang Yang, but because the person he has been dealing with in Qingshan Pharmaceutical over the years is another person: Ren Xiaomin.

He was much more familiar with Ren Xiaomin.

30 minutes later, Ren Xiaomin also hurried into the director's office.

Soon, after a few brief chats, everyone understood all the causes and consequences.

Zhang Yang did not expect things to develop like this. His original idea was to personally accompany He Ping to submit the information and then get it approved as soon as possible.

Unexpectedly,

After a few simple words, Director Kong slammed the table and threatened him, and then he simply revealed his identity.

But this little conflict is okay.

Director Song looked at Zhang Yang with an apologetic look on his face:

"Mr. Zhang, Mr. Ren, I'm very sorry about this. Don't worry, I will be personally responsible for the approval of your company's Clobazam."

"I will start the approval process right away, and working overtime this weekend will definitely speed up the approval process."

As he spoke, he looked at Kong Xiang standing beside him.

"Director Kong, please also express your opinion to Mr. Zhang."

Director Kong no longer had the arrogance and condescension he had just shown. He lowered his head and said:
"Mr. Zhang, I'm sorry. I had a bad attitude just now. I hope you can forgive me."

"Don't worry, just like Director Song said, I will work overtime this weekend and get all the approval documents for your company ready."

Zhang Yang exhaled slowly.

After a moment, he stood up and looked at Director Song.

"Director Song, thank you for your help. If you need any additional information, please contact us. I'll be leaving now."

As he spoke, he took the initiative to extend his right hand and shook hands with Director Song, then walked out of the office with He Ping and Ren Xiaomin.

……

Zhang Yang breathed a sigh of relief after resolving the issue of approval for the production qualification of Clobazam.

The next step is to find a way to imitate Clobazam.

Clobazam was developed and synthesized by a Danish company, H. Lundbeck, in 1966. After more than 60 years, its patent has long expired.

Zhang Yang quickly found the patent drawings of "Clobazam" in the database of the new drug research and development center.

In the pharmaceutical field, drug patents generally refer to patents on drug compounds.

What is a compound patent?
Simply put, Western medicine is actually a variety of artificially synthesized compounds. For example, "clobazam" is an organic compound with the chemical formula C16H13ClN2O2.

With the chemical formula, any slightly professional drug researcher can synthesize the compound through its chemical formula.

However, this does not mean that the compound with the chemical formula "C16H13ClN2O2" is equal to "clobazam".

In nature, the chemical formula of carbon is C, and the chemical formula of diamond is also C. We can’t say that carbon is diamond, right?

Therefore,
In addition to compounds, there is another very important patent that distinguishes drugs: the crystal form patent.

To put it bluntly, the crystal form patent refers to the internal molecular structure of the drug in the solid state, and its internal molecular structure truly determines whether the compound has a therapeutic effect.

and so.

A drug can be understood as: chemical formula + internal molecular crystal structure = a specific drug.

of course,

The crystal form patent of "Clobazam", like the compound patent, expired more than 60 years ago.

But unlike what many people think, the expiration of a patent does not mean that you can produce exactly the same drug.

The expiration of a patent only means that you can use the same crystal form and the same compound for free, but the original drug manufacturer will not disclose how this crystal form was synthesized or what route was used for synthesis.

You want to copy?

Then try it yourself step by step.

90% of pharmaceutical companies can slowly test out their products over a period of one, two, or even several years, but even so, subtle differences in crystal forms will lead to certain differences in the therapeutic effects between original drugs and generic drugs.

The difference is about 10%-20%.

This is also the reason why original drugs are definitely better than generic drugs.

While thinking, Zhang Yang carefully looked at the crystal patent and various materials of "Clobazam".

About two hours later, he already had a preliminary idea of ​​how to imitate "clobazam", and the next step was to verify his synthetic route in the laboratory.

It must be said that after so many times of extracting drug patents from the simulator, Zhang Yang's level in the field of biopharmaceuticals has greatly improved.
In addition, "Clobazam" is an old drug that has been around for decades and has a large amount of generic information, so it is indeed not difficult for him.

Zhang Yang soon came to the drug research and development center. In order not to disrupt the progress of other drug research and development teams, especially the improvement progress of the "Kidney Toxin Clearing Dialysis Needle", Zhang Yang decided to synthesize clobazam himself.

He immediately found Wei Tian and asked Wei Tian to arrange two less important researchers to help. However, when he told Wei Tian that the drug he was going to try to imitate was "clobazam", Wei Tian suddenly pushed the frame of his glasses.

"Mr. Zhang, a few years ago when I was in college, I accidentally saw a piece of news about 'clobazam'."

"It seems that the Danish company that developed Clobazam was acquired by Novartis..."

"Why don't you ask Novartis whether it has inherited the technical documents of its production process and synthesis pathway? The current market economic value of this drug is not high. With your relationship with Novartis, you should be able to buy it for a short time. Isn't this much faster than trying to copy it?"

Zhang Yang was slightly stunned. He really didn't know that Novartis might have mastered the production technology of "Clobazam".

But what Wei Tian said was very right. If there were production materials for original research drugs, they could just be purchased and produced. There was no point in imitating them.

A moment later, he called Friedman.

Friedman was a little surprised to receive Zhang Yang's sudden call.

"Zhang, luckily I'm awake. You called me in the middle of the night to check on the progress of the 'Kidney Toxin Clearing Dialysis Needle'? Don't worry, everything is going smoothly, and the response in our country is very good!"

Zhang Yang smiled politely twice and then stated his purpose.

Friedman was obviously surprised when he heard Zhang Yang asking about Clobazam:

"Zhang, we did acquire all the shares of the Danish company 'H. Lundbeck' a few years ago, and they are now our wholly-owned subsidiary."

"But I'm not very familiar with the drug 'clobazam'. Can I get back to you tomorrow?"

"of course can."

Friedman was very efficient. At nine o'clock in the evening, Zhang Yang received a long-distance call from Friedman.

"Zhang, I have confirmed for you that we do have all the production data and technical documents of Clobazam. Moreover, after so many years of improvement, our original Clobazam has a better sedative effect and fewer side effects and addiction."

Zhang Yang immediately felt relieved.

"That's perfect." "Friedman, I told you last time that I want to buy the production technology information of this drug. Of course... I only produce this drug in China, and I won't export it to affect the normal sales of your subsidiary abroad."

"You can name a price if you like."

"What's the price?"

Friedman's voice on the other end of the phone rose slightly by two degrees:
"Oh, Zhang, you look down on me as a friend!"

"Since you've already asked, how can I possibly ask for your money? I'll have a technician deliver the production technical data of this Clobazam to you tomorrow."

Zhang Yang was slightly stunned, and said hurriedly:
"No, Friedman, that's not necessary. This is your core information."

"You just need to authorize me to use it, and I will pay the usage fee, either in one lump sum or per box."

"Oh, Zhang, if you continue like this, you are not considering me as a friend..."

Friedman had obviously made up his mind that no matter how Zhang Yang refused, he would authorize the core production materials of "Clobacillus" to Tsingshan Pharmaceutical for free use.

In desperation, Zhang Yang had to accept Friedman's "good intentions".

The next day, two Novatis China staff members came to Tsingshan Pharmaceutical, bringing with them a thick stack of production materials.

It is the synthesis route and technical data of "Clobazam" originally developed by H. Lundbeck of Denmark.

Now Zhang Yang finally felt relieved. The two conditions for producing "Clobazam": "production qualification" and "pharmaceutical technology" have been met. The next step is to wait for approval!
Just when Zhang Yang finally breathed a sigh of relief, on the other side, the home of "Song Song's father" far away in Zhejiang Province was extremely messy.

"Is my son asleep?"

"Sleep."

Songsong's father glanced at his son who was sleeping soundly on the bed, then carefully closed the door of the room.

Next to him is his wife, Songsong's mother.

"Luckily, I didn't break too many things this time. Just two cups. By the way, did you see your phone break?"

Only then did Songsong's father take out his cell phone from his trouser pocket. The phone accidentally fell out when he was controlling his son.

He carefully checked the phone screen and breathed a sigh of relief:

"Fortunately not."

"That's good."

Songsong's mother sighed helplessly, her face full of fatigue.

Thirty minutes ago, their son suddenly had an epileptic seizure and then broke two water cups during the convulsions. Fortunately, Songsong's father was at home and the epilepsy was finally controlled after giving him medicine.

"This disease is really tormenting. We have taken the best medicine, but he still has seizures every year or so. Life is so miserable... What sins did we commit in our previous life to let our child suffer from such a disease!"

Songsong's father also sighed heavily.

Ordinary epilepsy drugs have no effect on refractory epilepsy. Only continuous use of clobazam can control the condition.

However... even if the child takes clobazam for a long time, he will occasionally have a sudden attack after a year or two. At first he thought it was due to his son, but later he asked several parents of patients and found out that this was a common phenomenon.

Later I found out that this was caused by taking generic drugs. This situation would not have occurred if I had taken original drugs.

However, it is good to be able to take generic drugs, but now even generic drugs are out of stock.

Thinking of this, his heart tightened and he looked at Songsong's mother sadly:

"Wife, how much clobazam is left at home?"

"There are only two boxes left... Songsong's father, we really need to think of a solution. What if we can't buy medicine and the child gets sick?"

"Hey... I'll go ask in the group and see if anyone can help share two boxes."

Songsong’s father quickly took out his mobile phone and opened the WeChat group.

Ever since the video of the "joint petition" was posted online, it has indeed caused quite a stir, and countless netizens have spoken up for them.

The latest news is that even the court is considering that "Tie Ma" was purchasing drugs for medical treatment and had no subjective intention to sell drugs, so they are discussing the decision not to prosecute "Tie Ma".

"Iron Horse" should not be sentenced.

But the problem is,

After this incident fermented, "Clobacum" was completely out of stock. Even those patients who had not purchased from "Iron Horse" before reported that all purchasing channels were cut off and no one was willing to help buy Clobazam anymore.

Come to think of it, before this incident happened everyone thought it was just purchasing medicine on behalf of others, and it was considered a good deed.

But no one expected that this matter involved drug trafficking. Even if Tiema was finally acquitted, who would be willing to take such a big risk for a few dozen or a hundred dollars in purchasing fees?
Songsong's father shook his head helplessly and started sending messages in the patient group, asking if there were any patients who had sufficient drug supplies and could help get a few boxes for emergency use.

Soon, replies from fellow patients came into the group.

"Songsong's father, we only have a few boxes of medicine left. I'm sorry, I can't share them with you."

"I do have about ten boxes left, and I can give you two. But this is not a solution. I have given away nearly ten boxes in the past two days, and it won't be long before they are all gone and everyone will be short of medicine!"

"Oh, yes. I originally thought that writing a 'joint petition' would draw attention to us, a vulnerable group, but I didn't expect that it would make it even harder to buy medicine!"

"Yes, Songsong's father, we have to think of a solution. This won't work! Why don't we take advantage of the current heat and contact a few media outlets for help, and ask the relevant departments to help solve the problem of buying medicine!"

Songsong's father looked at the messages quickly scrolling across the group screen, and thought about the only two boxes of medicine left in his home, and he had already made a decision in his heart!
"Okay, I was interviewed by a media outlet before, I'll contact them right away!"

The next day, Songsong's father contacted a media outlet that had interviewed him before. It was indeed as his fellow patients had said, the "Ice Age" incident was still quite hot. After the request for help was issued, it quickly attracted the attention of netizens who had been paying attention to this matter.

Everyone also began to realize that the arrest of "Iron Horse and Ice River" was an easy matter to resolve, and the court agreed not to prosecute.

But how to solve the problem of the drug "clobazam"?

"How can we solve this problem? If we want to solve this problem, we need to understand why no one in China sells it. Is it because the country doesn't allow it?"

"Haven't the relevant departments refuted the rumor before? Although it is a controlled drug, the state allows and supports major pharmaceutical companies to carry out the work of imitating 'clobazam', but no pharmaceutical company is willing to do it."

"Why?"

"Are you still asking why? The money is small but the work is complicated. It also involves drug control. One of the raw materials is heroin. Just think about it, isn't it troublesome?"

"Well, that being said, is there really no pharmaceutical company willing to take on some social responsibility? After all, there are more than 10,000 families!"

"Yes! By the way, isn't there Qingshan Pharmaceutical? Wasn't the boss of Qingshan Pharmaceutical named a role model of the times? The role model of the times should at least come out and set an example!"

Many netizens quickly thought of Tsingshan Pharmaceutical, especially the black fans of Tsingshan Pharmaceutical who finally found an opportunity to express their jealousy.

It’s not that they dislike Qingshan Pharmaceutical, these haters just can’t stand the fact that many fans praise Qingshan Pharmaceutical to the sky.

"That's right! I almost forgot about Qingshan Pharmaceutical! Didn't many people praise Qingshan Pharmaceutical for its righteousness and its dedication to the country and the people? Now that it's not making money, why doesn't Qingshan Pharmaceutical come out? Why doesn't it speak out?"

"Haha, I am dying of laughter. Why is no one bragging that Qingshan Pharmaceutical is the pride of the nation? If it is really the pride of the nation, it should come out and produce clobazam, and truly solve the problems of these patients!"

"That's right, if you're really awesome, come out and slap me in the face and make it swollen!"

(End of this chapter)