After being fired, I became the light of medicine

Chapter 127 That's right, I caught you (Subscribe)

Many people know that India is the world's largest generic drug factory, and its sales of generic drugs account for 25% of the global total.

But what many people don’t know is that India is also the world’s largest clinical trial base for innovative drugs.

Almost all well-known pharmaceutical companies in the United States and Europe have their own clinical trial bases in India.

Why do Western pharmaceutical companies want to establish clinical trial bases in India?
This requires us to start with India's generic drugs.

Why can India unscrupulously imitate new drugs developed by major Western pharmaceutical companies at a cost of tens of billions or hundreds of billions of dollars?
Do you really think that the Indian government does not recognize that "drugs are patented", so Indian pharmaceutical companies can imitate them at will?
What a joke! When did Western capitalists become so kind? They let India take advantage of the drugs they developed with their own hard-earned money, and then save all living beings?
It would be a piece of cake for the West to deal with India. The real reason why the West concedes that India can ignore patents and copy is that -

In exchange for human lives.

To be precise, it was paid for with the lives of Indians.

As everyone knows,

Developing any new drug not only has a long R&D cycle and high financial costs, but there are also not many patients willing to undergo clinical trials.

Especially in developed countries such as Europe and the United States, the cost of recruiting a patient for a full cycle of trials is about US$15000. What about India?

Three hundred dollars.

A gap of 50 times.

In addition, clinical trials of an innovative drug require at least several hundred people. If the drug composition is repeatedly modified and clinical trials are repeated, the number of subjects may even reach one or two thousand.

How can the cost difference not attract capitalists?

In addition, compared with the complete and strict approval processes of the European Union and the United States, India's clinical trial approval is extremely loose!

Died from drug testing?

Just pay some money!
Such an environment is simply paradise for pharmaceutical companies!
This is not alarmist. A few years ago, a well-known American pharmaceutical company was exposed for testing its innovative drugs directly on Indians without any animal testing.

The reason is that experimental monkeys are more expensive than Indians...

Therefore,
In such an environment, Western and Indian officials have reached a delicate balance: I don't mind you copying our innovative drugs, but you also allow us to conduct various clinical trials in India to the maximum extent possible.

Of course, Zhang Yang also knows something about the situation in India. If the "Kidney Toxin Clearing Dialysis Needle" is clinically tested in India, there will definitely be no problem with either safety approval or subject recruitment.

In addition, GlaxoSmithKline itself is the largest pharmaceutical company in the UK. As the sovereign state, GlaxoSmithKline has unique advantages.

Thinking of this, Zhang Yang nodded slightly. Seeing this, Lucas on the side quickly spoke up and took advantage of the situation:

"Zhang, if you are willing to give us the European agency rights for 'Kidney Toxin Clearing Dialysis Needle', we can also bear 80% like Novartis..."

“Oh no, we are willing to pay 100% of the clinical trial costs, anyway!”

"You don't have to worry about anything. We will take care of all the clinical trials and market approvals!"

Zhang Yang must be satisfied with this answer. As for the life safety of Indian people participating in the clinical trials?
Are you kidding? He doesn’t care about Americans, so why would he care about the deaths of Indians?
"Lucas, your proposal is very constructive, and I look forward to working with you again in depth."

"Okay, I agree to give you the exclusive European agency rights for this 'Kidney Toxin Replacement Injection', but the prerequisite is that you launch and pass the clinical trial as soon as possible!"

"Of course, our R&D team will also join in this process to continuously improve the drug ingredients."

"Like I said at the summit this afternoon, our current effective toxin removal rate is only 60%, but we are already seeing some progress in increasing it to 80%. We should see a breakthrough in a year at best, or half a year at best. Don't worry!"

Zhang Yang's last words completely reassured the two of them.

If this dialysis needle can really achieve 80% effectiveness, then let alone passing clinical trials, future market sales will definitely be even more promising!
"Haha, Zhang, you are really my best friend and the best partner of Novartis!!"

"Zhang, thank you for your trust. You can come to England when you are free next time. I will definitely accompany you."

Zhang Yang smiled, and the three of them clasped hands tightly together.

"Pleasant to work with."

……

Zhang Yang and his two companions decided on the main market agency rights for the "Kidney Toxin Clearing Dialysis Needle" while strolling along the Huangpu River.
Friedman and Lucas also changed their itinerary and urgently booked the same flight as Zhang Yang to fly to Qingshan Pharmaceutical.

When the three of them arrived at Qingshan Pharmaceutical, Ren Xiaomin, who was left at home, was stunned.

He didn't expect that Zhang Yang would be able to secure the agency rights for the "Kidney Toxin Clearing Replacement Injection" just by attending a kidney disease summit, and...

It also seems to have solved the problem that had been plaguing Tsingshan Pharmaceutical, namely, "how to conduct and whether to conduct clinical trials of dialysis needles."

Taking advantage of the gap, he hurriedly pulled Zhang Yang aside and lowered his voice:

"Zhang Yang, are you saying that we should not conduct trials on this 'renal dialysis replacement needle' in China first, but wait until clinical trials are completed in the United States and India?"

Zhang Yang nodded.

When Ren Xiaomin got the correct answer, a smile suddenly appeared on his face and his voice became even lower.

"Zhang Yang, how did you convince them? I can understand India, but the FDA is in the United States. Are Novartis really willing to do that?"

"This could lead to someone's death."

Zhang Yang shrugged and looked at Friedman, who was smiling.

He patted Ren Xiaomin on the shoulder and lowered his voice:
"Brother Ren, this world may not be as beautiful as we imagined."

"This society is cannibalistic!"

"what?"

……

Zhang Yang then handed over the details of the agency contract to Ren Xiaomin.

With the experience of previous agency cooperation, Tsingshan Pharmaceutical quickly signed letters of intent for priority agency rights in the US and EU markets with Novo and GlaxoSmithKline respectively.

As long as Novartis and GlaxoSmithKline pass the drug approval certification in their respective markets, they will automatically obtain the local agency rights for "Kidney Toxin Clearing Dialysis Needle".

At noon the next day, Friedman returned to the United States with a large amount of clinical data and patent authorization letters provided by Qingshan Pharmaceutical;
Lucas also left with a large amount of clinical data, but instead of returning to the UK, he flew directly to GlaxoSmithKline's clinical trial center in India.

After the two left, Ren Xiaomin found Zhang Yang again, and this time he asked about the "Kidney Toxin Clearing Dialysis Needle".

"Zhang Yang, our 'Kidney Toxin Clearing Dialysis Needle' has now officially entered the clinical trial stage. Do you think we should announce the latest progress on the official website? Or promote it?"

Zhang Yang thought for a moment and shook his head:

"Forget about the publicity, but we can publish the news about the 'Kidney Toxin Clearing Dialysis Needle' on the official website."

"On the one hand, we want to show you our latest research and development results, and on the other hand, this should also bring some hope to countless dialysis patients."

"it is good."

With Zhang Yang's permission, Ren Xiaomin immediately posted some simple functions and effects of the "Kidney Toxin Clearing Dialysis Needle" on the official website.

Tsingshan Pharmaceutical is currently considered a leading pharmaceutical company in China. Within two days of the news release, some medical self-media and public account UP hosts noticed Tsingshan Pharmaceutical's latest research results.

Soon, a series of articles introducing Qingshan Pharmaceutical's "Kidney Toxin Clearing Dialysis Needle" appeared on the public account. With rapid forwarding, they appeared in kidney disease patient groups, attracting the attention of many kidney disease patients.

"Look, look, Qingshan Pharmaceutical has produced new research and development results. This time it's finally the turn of our kidney patients!"

"Really? Let me see, has Qingshan Pharmaceutical developed a drug that can reverse chronic nephritis? That would be great if so!" "No, it's a 'dialysis replacement injection' mainly for dialysis patients. It seems that two injections can be given consecutively, which can replace the function of the dialysis machine for a short time!"

"Replace the dialysis machine? Let me see...hiss! Oh my god, reactivating the kidneys and restoring their urination function?! Do you know how long I haven't urinated? I haven't urinated for 5 years!"

"Fuck, I want to try it. I'm a dialysis patient. Even if it's just to experience the feeling of urinating again, I have to try it. When will this drug be available on the market?!
"It's too early to launch it. This is the latest research and development results, and we don't even know when clinical trials will begin..."

"Qingshan Pharmaceutical is very efficient. Once they publish their research results, they will almost immediately start clinical trials. Wait."

"Okay! I'll wait!"

Just as Zhang Yang thought, many dialysis patients began to look forward to the "Kidney Toxin Clearing Dialysis Needle" after noticing it, and they all hoped to get news about the clinical trials as soon as possible.

Of course, Zhang Yang could not see the discussions in the patient group. At this moment, he had already started the next stage of work on the "Kidney Toxin Clearing Dialysis Replacement Injection".

In the coming time, he will lead the entire R&D team to gradually increase the toxin removal effect from 60% to 80%, and finally realize a complete product.

However, apart from this, he did not forget another unexpected gain at this "Kidney Disease Summit", that is, BI's "catalyst needle" that improves the toxin removal effect of the dialysis machine by 7%.

Zhang Yang’s idea was very simple. BI’s “catalyst needle” could break down large molecular toxins in the human body, thereby increasing the toxin clearance rate of the dialysis machine. So could the “catalyst needle” be used in conjunction with its own “kidney toxin removal replacement needle”?
Even more so, can some of these "catalytic molecules" be added into the "kidney toxin clearing drugs"?
With this idea in mind, Zhang Yang asked Wei Tian to start collecting and gaining a deeper understanding of the information about this "catalyst needle".

Of course, BI's "catalyst injection" is currently only in the laboratory stage and has not even been clinically tested...

Zhang Yang was not in a hurry either.

Time passed quickly, and about three weeks later, news from Novartis first came from the United States.

The "Kidney Toxin Clearing Dialysis Needle" has passed the clinical trial application and is about to start phase I clinical toxicity testing.

Almost at the same time,

There was also news from GlaxoSmithKline's Lucas in India.

Compared with the FDA which is still taking one step at a time, GlaxoSmithKline's progress in India is a big step forward!

Because the "Kidney Toxin Clearing Dialysis Needle" is only for specific dialysis patients, the Phase I and Phase II clinical trials are combined and conducted simultaneously.

Zhang Yang was of course happy to see this situation. After calling the two to congratulate them, the "Kidney Toxin Clearing Dialysis Replacement Injection" officially kicked off the clinical trial!
While Lucas was conducting clinical trials in India in full swing, the generic drug wholesale market a few kilometers away was bustling with small packages being loaded into courier trucks.

These packages of medicines are almost all purchased from overseas. They will be transported by planes and cargo ships across the sky and ocean to the patients...

A week later,

One of the packages arrived in Shenzhen, a coastal city in China, via a cargo ship across the Indian Ocean.

Brother Hu sat in the living room, looking at his five-year-old daughter with eyes full of doting.

Suddenly, the cell phone in the bag rang.

He quickly covered his phone, fearing that the sudden ringing would scare his daughter.

After a moment, he quickly picked up the phone and whispered:
"Hello, who is it?"

"I'm the courier. Your package has arrived. Please come down and pick it up."

"Oh."

Hu A'di said "oh" and calculated the time quickly in his mind.

Express delivery from India to China takes about 3-10 days, air transportation takes about 3 days, and sea transportation takes about 7 days if you are lucky.

It has been exactly one week since I last contacted the Indian seller to ship the goods... The timing matches, so it should be the batch of medicine I bought.

However, he soon felt something was wrong.

Usually the courier would just send a text message and leave it at the courier station, so why did he call in person today?

Fortunately, this thought only flashed through his mind, and he immediately said:

"Thank you. Please leave it at the courier station. I'll pick it up when I'm free."

There was silence on the other end of the phone for two seconds.

"Um... no; the thing is, your package is a little damaged, you need to come and see it in person."

"If there is a problem, just refuse it on the spot and I will return it."

damaged?

Hu A'di's heart suddenly skipped a beat. He knew very well that the package contained all generic drugs that he had purchased from India.

If any problems arise, money is a small matter. The key is that many patients are still waiting to take medicine!
Those are life-saving drugs!

"Okay, wait for me for two minutes, I'll be down right away!"

Hu A-di felt a little uneasy and put his phone back into his trouser pocket.

He looked at his five-year-old daughter, thought for a moment, and finally walked into the bedroom to wake up his wife who was catching up on her sleep.

His daughter was very noisy all night last night, and his wife Wang Mei was also tossing and turning all night. Now she finally got some sleep.

"Mei, wake up."

"Brother, what's wrong?"

"There's something wrong with the express package I bought from India. The courier said the package seems to be damaged. I'll go down and take a look. You look after my daughter."

Wang Mei raised her sleepy eyes and looked at her daughter, then nodded:
"Okay, go ahead, brother."

Hu A'di finally felt relieved. Her daughter was suffering from a rare disease, epilepsy. Once she was emotionally excited or stimulated, she would easily have an attack. This meant that the couple had to keep an eye on their daughter almost all the time and anywhere.

He quickly went downstairs to the express delivery station and immediately saw the courier boy standing next to the delivery truck.

Hurrying over:
"Hello, courier. I'm the one you just called to say the package was damaged. I'm here to check on the package..."

The courier boy glanced at Hu A-di evasively, then looked at the two people around him.

Hu A'di felt something strange. At this moment, two people next to the courier suddenly jumped out, grabbed his hands from the left and right, and then pressed his head down with force.

The sudden noise startled the onlookers who were picking up the parcels. Before they could come to their senses, another plainclothes officer took out his police ID from his bag and explained to everyone:
"The police are investigating the case. The police are investigating the case. Don't be afraid."

police?

Hu Adi panicked and shouted:
"Comrade police, you have arrested the wrong person! You have arrested the wrong person! I am a good person!"

The policeman who had taken out his police ID just now put it away, then walked up to Hu A-di and looked straight at him:
"Is your name Hu Adi?"

"Yes."

"What did you buy in the express?"

"I bought...I bought some generic drugs, generic drugs for rare diseases!"

"medicine?"

"That's right, you are the one we caught!"

(End of this chapter)