After being fired, I became the light of medicine

Chapter 124 The Kidney Toxin Removal Injection Surprised Everyone (Subscribe!)

BI's influence in the field of kidney disease drugs is still recognized by everyone.

After hearing what Hans said, everyone stopped discussing and looked towards the center of the booth.

Hans didn't beat around the bush and projected the prepared information onto the screen through his mobile phone, then said:

“As we all know, there are more than 500 million dialysis patients worldwide, the vast majority of whom use the most common form of hemodialysis.”

"But hemodialysis also has major drawbacks. Currently, regardless of the brand of dialysis machine or dialysis fluid, it can only remove about 85% of the toxins in human blood."

“Some large molecular toxins and toxic elements produced by some metabolites cannot be completely removed by hemodialysis.”

"This means that dialysis patients always have some toxins remaining in their bodies at all times. Eventually, these toxins will invade the human body for a long time, eventually causing problems such as heart failure and organ failure."

"It can be said that this drawback has become the biggest factor affecting the lives of dialysis patients!"

After the words were spoken, everyone present nodded.

The principle of the dialysis machine is actually the same as that of a water purifier, which mainly relies on the principles of adsorption and diffusion.

Adsorption is the process of using the adsorbent in the dialyzer to absorb metabolites and some toxins in the blood, but adsorption is a physical method and it is difficult to achieve 100% adsorption.

The diffusion principle can be understood as the concentration principle.

The blood of patients with uremia has high concentrations of metabolic waste products such as urea, creatinine, uric acid, and solutes such as excess electrolytes. When the blood passes through the dialysis machine, these high-concentration toxic substances will be separated and diffused into the dialysate, thereby purifying the blood and harmful substances.

The diffusion principle is also the main principle of the dialysis machine.

However, both of these methods are actually high-probability methods. Whether it is adsorption or diffusion, it is impossible to achieve 100% complete filtration of toxins.

At this point, Hans continued:

“So, given that hemodialysis currently cannot achieve a higher toxin filtration rate, we developed such an injection;
It can be injected into the patient's body through the blood catheter when the patient is undergoing hemodialysis, so that the drug components can act directly on the blood, thereby achieving the purpose of increasing the filtration rate of dialysis toxins. "

"You can think of it as a catalyst, just like the 'fuel saver' in a fuel car. Its drug ingredients can quickly break down harmful substances such as large molecular toxins and residual metabolites in the blood, allowing the dialysis machine to better adsorb and diffuse the blood, thereby achieving a higher toxin filtration rate for the dialysis machine."

"According to the data obtained from our laboratory, the dialysis effect can be increased to 92% after adding this drug, and the effective improvement rate has increased by 7% compared to the current level!"

"The effective filtration rate of normal people is about 98%, which means that if this drug is successfully launched on the market, we will be able to increase the current median survival time of dialysis patients from 13.78 years by 3-5 years."

"Even in the future, we may be able to achieve the same 98% filtration rate for dialysis patients as normal people through continuous improvement!"

"This is a historic moment!"

As soon as the words fell, everyone present couldn't help but take a deep breath.

Zhang Yang noticed that even Friedman and Lucas beside him were slightly startled, and their eyes became serious and earnest.

It must be admitted that once such a drug is developed, it will definitely be a major milestone in the history of renal dialysis!

and……

Both of them realized how much commercial profit this drug would bring once it was on the market!
Even though there are only 500 million dialysis patients in the world, these patients undergo dialysis three times a week, which means twelve times a month!
If this drug is added to every dialysis session, the benefits will be absolutely unimaginable!
Friedman and Lucas were frantically calculating the market prospects of this drug in their minds, and the doctors on the left, including Dr. Xili, were also completely interested.

Dialysis has been popular for many years, and its toxin filtration rate has been improving.

However, after the filtration rate reached 20% in the past 85 years, it has been difficult to increase it further. After all, there is still a big difference between machines and human kidneys. Even though modern technology is so advanced, it is still impossible to achieve such precise operation as human kidneys.

Now BI companies are taking a different approach, and this approach does sound very likely to succeed.

All of a sudden, doctors raised their hands to ask questions, and the scene was very lively.

Zhang Yang was also surprised by BI's drug. Recently, because of the "Kidney Toxin Clearing Dialysis Replacement Injection", he has been paying attention to various matters related to dialysis patients.

The biggest trouble in the life of dialysis patients is that they have to undergo dialysis three times a week and are almost tied to the dialysis machine.

The biggest problem in survival is that toxins accumulate in the body for a long time and are not eliminated thoroughly.

If this drug can really be put on the market, it will definitely significantly improve the survival time of dialysis patients!
"BI Company still has something to offer..."

Zhang Yang couldn't help but sigh, but suddenly, an idea flashed in his mind and a fantastic idea suddenly popped up in his mind.

if,

The "Kidney Toxin Clearing Dialysis Needle" in my hand, which has only 80% filtration effect, can be combined with the drug ingredients of BI company...

hiss!
You should know that the "Kidney Toxin Clearing Dialysis Replacement Injection" is a drug that can activate the kidneys after injection and allow patients to resume urination.

However, because it has only 80% drug toxin removal effect, it can only last for a maximum of two injections before a comprehensive dialysis machine is required to avoid accumulation in the body.

If BI's catalyst is added, will it improve the toxin filtering effect of the "Kidney Toxin Clearing Dialysis Needle"? !

If that were the case!

Wouldn’t it be possible for the “Kidney Toxin Clearing Dialysis Replacement Needle” to completely replace the dialysis machine?

The more Zhang Yang thought about it, the more excited he felt. However, he soon calmed down. BI's drug had not even started Phase I clinical trials, so it was not certain whether it would actually be effective on the human body.

While he was thinking, Hans from BI's communication with the doctors finally came to an end.

Everyone can see that many doctors are very interested in the drug BI, and some even took the initiative to leave Hans' contact information, hoping to obtain more relevant information.

Hans was also quite satisfied with the publicity this time. Although it is still in the laboratory stage, after such publicity, once the drug enters the clinical phase I, it will definitely attract the attention of many kidney disease hospitals around the world. If it can be put on the market, it will undoubtedly be quickly introduced to the global market.

That’s what the Kidney Summit is all about.

"Okay, that's all I have to share about medicine today. Thank you everyone."

Hans smiled and waved as he walked down the booth. Warm applause suddenly broke out in the conference hall. This was applause from the bottom of everyone's heart for BI!
This is cutting-edge technology!

Friedman and Lucas clapped their hands, too; apart from the business angle, they were equally happy about the possible medical advances.

Hans returned to his seat, and the time quietly came to 4:30 in the afternoon, with only half an hour left until the end of the summit.

The host seemed to realize that BI Company should be the last speaker, so the "new drug sharing" session ended.

Next, according to the meeting process, the last half hour is a period for free speech and communication between major pharmaceutical companies and doctors.

but.

Adhering to her professionalism, she still glanced at the pharmaceutical company's seat, and then asked politely:
“Are there any other companies that want to come on stage to share their new drugs? If not, we will move on to the last stage.”

After saying that, she was about to start her next opening speech, but at this moment, Zhang Yang stood up.

"Yes, I also want to share a drug."

Zhang Yang's words were soft, but the moment he stood up, everyone present was stunned.

Friedman and Lucas on the side opened their eyes wide and looked at Zhang Yang in surprise.

Good guy!
Just now you said you wanted to join the research and development of kidney disease drugs, and now you are going to take the stage? !
Is this going to be shown?

Is this going to be shared?

The host was stunned for a moment, then looked at the sign in front of Zhang Yang and said quickly, "Okay, then welcome Mr. Zhang Yang from Qingshan Pharmaceutical to share his medicine with us."

"Everyone welcomes you with applause."

The surprised Lucas and Friedman finally reacted and led the applause, and then warm applause broke out in the conference room.

Dean Gan Weiguo, who was sitting in the doctor's seat, watched Zhang Yang calmly walk up to the stage, and a cold sweat broke out on his forehead.

He also knew that Qingshan Pharmaceutical was interested in developing kidney drugs, but this time the original intention was to let Zhang Yang show up and feel the atmosphere.

But you actually went on stage?!
Of course, Zhang Yang had no idea what Dean Gan Weiguo was thinking at the moment. He walked up to the booth, took a deep breath, and skillfully shared the prepared information on the screen via his mobile phone.

Then, he stood in the middle of the booth, coughed lightly into the microphone, and said in a low voice:

"Hello everyone, I am Zhang Yang from Qingshan Pharmaceutical."

"What I brought today is also a drug for dialysis patients. To be more precise, it is an injection."

"Its chemical name is 'Polyethylene glycol-nephrotoxicity targeted scavenger injection', and its Chinese name is 'Kidney toxicity scavenger dialysis replacement needle'."

"Its effect, just like the name of the drug, allows patients to get rid of dialysis machines in a short period of time. Only an injection is needed to achieve the same effect as dialysis!"

Get rid of the dialysis machine!
Injections can achieve an effect similar to dialysis!

As soon as the words fell, everyone present was stunned and surprised!

Can a single injection replace dialysis? !

impossible?

You know, what is the most difficult part about replacing dialysis with injections!
It’s not about how to remove toxins, but how to get toxins out of your body!

Amid great doubts, a doctor immediately stood up and spoke:

"Mr. Zhang Yang, excuse me for interrupting you. You should know that almost all dialysis patients will lose their urination function after long-term dialysis. May I ask you, how do these dialysis patients excrete toxins without the urination function?"

Zhang Yang smiled slightly and said:

"That's right. Most dialysis patients have lost their urination function, but after our 'Kidney Toxin Clearing Dialysis Replacement Needle' is injected intravenously, they will be able to urinate again within an hour!"

Urinating again!

As soon as he finished speaking, not only the doctor who asked the question just now, but all the doctors who were invited to the scene could not sit still!
They are the world's top nephrologists, and they have never heard of any drug that can activate the kidneys to start urinating again!

What a joke!
The root cause of uremia is kidney damage that leads to the inability to filter toxins and the inability to urinate!
For example, in the field of kidney disease, there is a very common classification of kidney disease called "nephrotic syndrome". Once the patient reaches renal failure and uremia, the whole body will suffer from edema. The reason is that the kidneys stop working due to severe damage, resulting in a large amount of toxins and water that cannot be excreted from the body!

At this time, the doctor will use a large amount of diuretics, but diuretics also have drug resistance. They are very effective the first time, but after a few times, the kidneys will develop drug resistance and the effect will not be effective!

The only final solution is dialysis.

And now!
Zhang Yang, the president of Qingshan Pharmaceutical, actually said that he could reactivate the shut-down kidneys?!

Zhang Yang smiled slightly, understanding everyone's doubts, and continued:

"I know everyone has doubts, so let me first briefly introduce the principle of our 'Kidney Toxin Clearing Dialysis Replacement Needle'."

"First, after the drug is injected intravenously, its drug molecules will quickly reach the renal tubular epithelial cell pathway.

The renal tubular epithelial pathway is the key point to stimulate the kidney to start.

Once the connection is established, the pathway mitogen-activated protein kinase (MAPK) is reactivated, thereby stimulating the kidneys to open the channel and ultimately achieve urination.”

After speaking, he paused and continued:
“It is undeniable that patients who meet the dialysis criteria have severe kidney damage, but I believe you cannot deny that even patients with advanced uremia still retain 20-30% of their kidney function.”

After these words were spoken, many shocked doctors nodded.

indeed.

Uremia does not mean complete kidney necrosis, but when the number of glomeruli is reduced to only 50, the human body has difficulty completing its work, and symptoms such as edema and vomiting will gradually appear.

At this time, 99% of people will be sent to the hospital. Once they are sent to the hospital for dialysis, the remaining glomeruli will almost always retain their functionality.

"now it's right!"

Seeing everyone nod, Zhang Yang continued:

"So, we only need the kidneys to open the urinary pathway, and the remaining 20% ​​of kidney function is enough to form bottom urine, and then the urine formed under the function of the drug is excreted through the urinary system."

"For patients who are still producing urine during dialysis, the situation is even simpler. Their kidneys are simply shut down at the request of their immune system, and their urination function is actually normal."

"We just need to reactivate their kidneys to enable urination..."

After the words fell, the doctors present took a deep breath and looked at each other.

I have to say that the principle Zhang Yang explained does make sense, but!
Is it true that Tsingshan Pharmaceutical, which had previously made no achievements in the kidney field, is so strong in kidney research?
The doctors present were perhaps just surprised, but the eyes of the pharmaceutical company representatives nearby were filled with shock for the first time!

You know, whether it is Roche's "Empagliflozin" or the drugs promoted by the other two companies, they are all eye-catching.

Even BI's catalyst for improving dialysis is just amazing!
What about Qingshan Pharmaceutical’s “Kidney Toxin Clearing Dialysis Replacement Injection”?

Its drug mechanism is enough to make people shocked and incredible!

Others may not know, but they know it very well in their hearts. Although Zhang Yang makes it sound easy, it is not easy to find the pathway to activate the kidneys and the target to activate the kidneys!
I admit that Tsingshan Pharmaceutical is very strong in the fields of blood diseases and liver diseases!
But is Qingshan Pharmaceutical so strong in the kidney field? !

And at this moment, Zhang Yang's voice was heard again.

"Okay, now that everyone has no questions, let me briefly introduce the toxin removal effect of our 'Kidney Toxin Clearing Dialysis Replacement Needle'!"

"At present, our 'dialysis replacement needle' has achieved a 60% toxin filtration rate in the body, which is still a long way from the 85% effective filtration rate of the dialysis machine, but we are confident that we can increase the toxin filtration rate to 80% in the future."

60%.

Everyone breathed a sigh of relief.

"However, although our effective filtration rate cannot reach the effect of a dialysis machine at present, we have a huge advantage over traditional dialysis, which requires toxins to accumulate for two days before dialysis!"

"The body's urination function will resume one hour after we inject the drug."

"That is to say, the 'Kidney Toxin Clearing Dialysis Replacement Needle' will completely simulate the human kidney. After ingesting food, toxins can be excreted from the body through the action of drug molecules immediately, without having to wait for toxins to accumulate!"

“This is our greatest advantage!”

As soon as the words fell, the scene fell into silence.

Everyone's eyes widened and they suddenly realized this very critical issue!
Clear in time!

……

PS: Thanks to Francisco for the 500-coin reward!
The previous chapter was 4.8K, this chapter is 4.7K, a total of 9.5K. Although it is not 500 words a day, it is only words away!
This one is an additional update for Ma Jia Box!
Asking for a monthly ticket.

I will continue to update ten thousand times a day tomorrow and add more chapters for the big guys!

(End of this chapter)