After being fired, I became the light of medicine

Chapter 12 New trouble—tight funds!
The next morning, Zhang Yang arrived at the clinical trial center early.

Now his daily work is very simple. In addition to recruiting as many subjects as possible, he also maintains communication with the clinical center and solves problems encountered in clinical trials in a timely manner.

After staying at the clinical trial center until ten o'clock in the morning, he came to the hematology inpatient department.

In fact, in the division of labor in clinical trials of innovative drugs, the clinical trial center is more responsible for the tasks of enrolling, examining, and administering medication to patients after recruitment.

The bulk of the work of recruiting subjects actually falls on the shoulders of various departments.

The reason is simple. Doctors in the department understand the patient's condition better and are more likely to recommend the patient to participate in clinical trials of innovative drugs.

So generally speaking, after major pharmaceutical companies begin clinical recruitment, they will arrange one or two interns in the corresponding department's inpatient and outpatient departments to help contact patients, fill out information, etc.

Zhang Yang is no exception.

Qingshan Pharmaceutical’s contact person in the hematology department is an intern named Li Xue.

"Li Xue, you're busy. How's the recruitment going these days?"

When I arrived at the hematologist's office, Li Xue was busy organizing medical records.

Although she is the liaison officer of Qingshan Avatrombopag, her main job is still an internship in the department.

Seeing Zhang Yang coming, she greeted him hurriedly and warmly.

"Mr. Zhang, you are here. Please take a seat."

"The recruitment situation these days is much better than before. Especially a few days ago, the first batch of patients who participated in the trial reported that the treatment effect was good and their platelet count increased a lot. Now they are actively promoting it to us."

"Two patients came to ask about this this morning. I think the recruitment work will go more and more smoothly in the future."

Zhang Yang felt slightly relieved; this conclusion was pretty much what he had imagined.

Thanks to the excellent therapeutic effect of Qingshan Avatrombopag, once the word spreads, subsequent recruitment work should be much easier.

"That's good. Thank you for your hard work!"

"It's not hard, it's what you should do."

The conversation between the two was simple and direct. After chatting for a few more sentences, Zhang Yang left the inpatient department.

In the next few days, just as Li Xue said, with the personal promotion of the first batch of test subjects, many patients who were originally on the sidelines chose to give it a try.

quickly,

The recruitment of the second, third and fourth groups of patients has been completed, and the Phase II clinical trial of "Qingshan Avatrombopag Tablets" has begun.

Gradually, as Qingshan Avatrombopag continued to recruit new patients, the first batch of fifteen subjects also unknowingly completed the eight-week Phase II clinical trial.

When the complete two-month data was placed in front of Feng Gang, deputy director of the clinical center, he was completely amazed!
The first batch of fifteen patients were divided into an experimental group and a control group (placebo group). In just two months, the clinical data of the eight patients in the experimental group completely crushed that of the control group!
Moreover, judging from the clinical data of the experimental group, the therapeutic effect demonstrated by "Qingshan Avatrombopag" is indeed no different from that of the foreign "Avatrombopag" which costs as much as 7800 yuan per box!
Feng Gang was shocked, Zhang Yang and Ren Xiaomin were also very happy, but the happiest ones were the first batch of patients who participated in the clinical trial.

They are all patients with blood diseases, and most of them participated in the trial just with a fluke mentality. However, they did not expect that "Qingshan Avatrombopag" would actually give them such a big surprise in just two months!
Yan Xiaoduo is one of them.

Two years ago, at the age of 30, she was diagnosed with aplastic anemia.

In the past two years, she has tried the most effective treatment options currently available, including bone marrow transplantation and ATG, but unfortunately, the final results of both bone marrow transplantation and ATG were not satisfactory.

There was no other choice, and under the doctor's advice, she could only take the most conservative treatment method - drug therapy.

But it seemed as if God was playing a joke on her. She did not respond well to traditional domestic hormone drugs and blood-raising drugs. She had no choice but to switch to "Eltrombopag".

"Eltrombopag" did have some effect. Soon her platelets and red blood cells began to increase steadily. In one month, they increased from 10 to 30 units.

But the price of more than 2000 yuan per box really made her feel distressed. Moreover, a check-up showed that the transaminase and bilirubin in her liver were rapidly increasing.

The final diagnosis was acute liver injury.

She knew very well that this was the side effect of Eltrombopag.

But between maintaining life and liver toxicity, does she have a choice?

The doctor had no choice but to recommend a better drug to her. She still remembers the doctor's exact words until now: "This is the best thrombopoietin in the world. You can try this drug, but it's a little expensive."

"How much more expensive can it be?"

But when she checked it online, she was immediately in despair.

This imported drug called "Avatrombopag" costs as much as 7800 yuan per box, or a total of 400 yuan per pill.

This kind of medicine is not something that an ordinary person like her can afford!

Yan Xiaoduo was desperate and had to take Eltrombopag, which had serious side effects, while taking Chinese patent medicine for liver protection.

This is life!

Until one day, she came across a promotional advertisement for an innovative drug in Phase II clinical trials...

"Qingshan Avaqubopa"!
Thinking of this, Yan Xiaoduo came back to her senses and couldn't help but take a look at the test results she had just received in her hand.

The three most important indicators for blood patients:
[Platelets...80, normal! ]

[Red blood cells...3, normal! ]

[White blood cell count...2.8, normal! ]

Although the platelet count has just reached the lower limit of normal values, compared with the platelet counts in recent years which were often only 10, 20 or even single digits, this is already the best blood picture in recent years!

She has already asked the doctor, as long as she can maintain this blood count, there will be no problem in leading a normal and stable life!
It might even be possible to get back to normal!

Yan Xiaoduo was completely excited and could no longer suppress her inner excitement. She quickly opened the patient group on her mobile phone, then took a photo of the report in her hand and sent it to the group. She couldn't wait to share her joy with other patients.

"@Everyone, here is the final blood report of the two-month clinical trial, everyone please take a look!"

It was noon at this time, and just moments after the message was sent, many people in the group immediately responded.

"Group leader, you finally showed up. Let me see your report..."

"Hiss! Xiaoduo, is this really your blood report? Are your platelets back to normal?"

"Fuck, is this true? Xiaoduo, is this new drug trial you participated in really having such a good clinical effect? ​​I've been taking Eltrombopag for half a year and my platelet count is only 60 now!"

"Oh my god! This is totally beyond my imagination. To be honest, if you hadn't tried the drug yourself, I would have thought you were a liar! Is this drug from Qingshan Pharmaceutical really so effective? Or is "Avatrombopag" really so effective?"

"I was also shocked. It's only been two months and the platelet count has returned to normal. Has anyone in the group taken 'Avatrombopag'? Can you tell me if 'Avatrombopag' is really that effective?"

"No one in our group can afford this medicine. Even the doctors in our hospital have never seen this medicine!"

Yan Xiaoduo could fully understand the shock of her fellow patients, and she began to patiently answer every question in the group.

Obviously, as one of the first people to have undergone two months of Qingshan Avatrombopag treatment, she is qualified to answer questions!

However, just as the patients were excited, Zhang Yang found that as more and more patients joined the group, his funds began to fall behind.

Clinical trials, as the name suggests, are trials conducted on living humans.

But everyone knows that the emergence of a new drug is always accompanied by a lot of uncertainties, such as whether it is liver toxicity, kidney toxicity, and whether it will have an impact on human organs?

Therefore, if a new drug wants to recruit enough patients, it not only needs to have the right drug for the right condition, but also needs to provide patients with some cost compensation during the recruitment process.

The number can be as high as tens of thousands or as low as a few hundred.

"Qingshan Avatrombopag" naturally also provides each subject with a considerable amount of fees.

as a last resort,
Faced with the funding gap at this time, Zhang Yang had no choice but to mortgage his house and car. No matter what, he had to complete the Phase II clinical trial!

And at this moment,
The discussion about "Qingshan Avaqubo Tablets" in the patient group became more and more heated, and successfully attracted the attention of other pharmaceutical companies. A document about Qingshan Pharmaceutical, Zhang Yang and Ren Xiaomin was placed on the desk.

(End of this chapter)