After being fired, I became the light of medicine

Chapter 116 A historic moment that shocked the world! (Additional chapter for Ma Jia Box!)
"@马晓红, stop playing dead and speak out. Didn't you claim that 'LivClearX' was a miracle drug? But it turns out that the patent for the drug belongs to Qingshan Pharmaceutical! Are you surprised or not?!"

"Haha, there are still those idiots who say Novartis is a beacon of mankind and that Novartis benefits all mankind. Come out, I want to see how you brag about Qingshan Pharmaceutical!"

"Hahahaha, awesome! I saw a lot of comments online and a lot of Americans are upset. Are you guys upset too?"

"Hahaha, they are bound to be defeated. Anyway, as long as there is something wrong in the country, they will definitely talk about the free market and the system. Now I want to see what excuses they have?!"

"Hahaha, @马晓红大公知 why are you silent? Is there no internet?"

"I still like your rebellious look."

When the news spread back to China, those netizens who supported Qingshan Pharmaceutical did not expect that the revenge would come so quickly and so satisfyingly!

It was so cool that Qingshan Pharmaceutical didn’t even need to respond, Novartis’ clarification statement directly humiliated all the public intellectuals.

All were killed.

However, after the carnival and pride, through Novartis’ clarification, netizens really began to care about Tsingshan Pharmaceutical’s “hepatocyte activator” for the first time!
"Brothers, let's talk and argue, what's the status of Qingshan Pharmaceutical's 'liver cell activator'? Is it going to be launched on the market?"

"I don't know. It is said that the clinical trial is already in phase III, but I don't know when it will end..."

"Do you think Qingshan Pharmaceutical has noticed what's happened recently?"

Zhang Yang certainly noticed what happened recently, but he just took a quick look at Novartis' clarification and then plunged into the final sprint of the Phase III clinical trial of "Hepatocyte Activator" again!
At this moment, the "hepatocyte activator" has entered the third month of Phase III clinical trials, which is also the critical last month!
Because the condition of patients with "decompensated" cirrhosis is indeed quite serious, he adjusted the original 75% activator component to 90% at the beginning of the third phase of clinical trials.

By the second month, he had corrected the 90% components to 100%, truly turning it into a complete form.

After taking the complete "Hepatocyte Activator" for two months, the clinical effect of the "Hepatocyte Activator" finally achieved a breakthrough!
The breakthrough is -

The compensatory stage, which is also the early stage of liver cirrhosis, began to show signs of reversal after two months of taking it!

reverse!

As we all know, cirrhosis is a disease that is difficult to quantify using a single indicator.

Currently, the conventional method of diagnosing liver cirrhosis is mainly through imaging, namely B-ultrasound and CT.

Simply put, B-ultrasound is used to observe whether there are obvious changes in the liver morphology and whether there are obvious hardened nodules, while CT is used to observe whether its density decreases.

But the most accurate and only gold standard in clinical practice is:
Liver biopsy - liver puncture!
Liver biopsy is a procedure in which a puncture needle is used to penetrate the skin to remove a piece of liver tissue from the liver. A liver cell biopsy is then performed on the removed liver tissue to determine the true condition of the liver.

The puncture can determine the degree of inflammation and fibrosis of the liver. The degree of inflammation represents the ongoing damage to the liver.
Fibrosis is a sign that the liver has been damaged!
Judging from the two-month medication period, the first inflammation level of patients in the compensatory stage, that is, early cirrhosis, dropped from A3 (severe inflammation) to A1 (mild inflammation)!
The focus is on fibrosis!

It has dropped from grade F4 (cirrhosis) to F3 (fibrosis)!
You know, fibrosis and cirrhosis are two completely different conditions!
Cirrhosis of the liver is a series of hard nodules, just like scars left on human wounds!

Although fibrosis still refers to a large amount of unhealthy liver tissue, it is not completely necrotic. Strictly speaking, fibrosis is "alive" and can be reversed!
It can be reversed!

This clinical result completely inspired the entire Qingshan Pharmaceutical R&D team. Everyone has determined that if these patients with early liver cirrhosis continue to take the "hepatocyte activator" for a long period of time,
It is entirely possible to transform a patient with cirrhosis into a "patient with liver fibrosis" or even an ordinary, common "patient with impaired liver function"!
Qingshan Pharmaceutical!

Hepatocyte activator has truly achieved the first reversal of "liver cirrhosis" in patients in human history!

In the conference room of Qingshan Pharmaceutical's Drug Research and Development Center, Zhang Yang listened to Wei Tian's complete report and was a little excited when he saw the 40-centimeter-thick clinical data in front of him!
In previous Phase I and Phase II clinical trials, the effects of 50%, 60% and even 75% could only be maintained, and the blood indicators of patients with cirrhosis could be slightly improved, but the reversal from cirrhosis to fibrosis has not yet been truly achieved!

just now!

done!
of course,

Although the reversal of late-stage liver cirrhosis has not yet been seen, he believes that it is not impossible to reverse late-stage liver cirrhosis to mid-stage or even early-stage after long-term medication!
As long as it is reversed to the middle or early stages, the patient's life will be greatly improved!
Thinking of this, he took a deep breath and no longer hesitated!
“Although our Phase III clinical trial has not yet ended, let’s announce this historic moment to the public!”

"We have finally developed the first drug in human history that can reverse cirrhosis!"

The thirty or so R&D personnel present clenched their fists in excitement;
Although the entire drug development was led by Mr. Zhang Yang, everyone contributed their sweat to it!

From animal experiments to clinical trials, drugs are improved time and time again, and experiments are repeated again and again!

They are equally worthy of respect!

……

Just when Zhang Yang was so excited that he decided to announce the important news that "hepatocyte activator" could reverse liver cirrhosis,
The discussion about Novartis' "LivClearX" and Tsingshan Pharmaceutical is still ongoing on the domestic Internet.

Of course, the news about Novartis' "LivClearX" on the North American Internet has calmed down.

After being angry for a few days after initially learning the truth, countless middle-class Americans ultimately chose to shake their heads and shrug their shoulders helplessly when faced with the real effects of "LivClearX". After all, health is more important.

Moreover,
Didn’t Novartis say that “LivClearX” is locally produced, locally sold, and locally improved?
Then it can also be considered a joint venture drug.

Since it's a joint venture, it doesn't count as aiding the enemy.

However, just when the entire United States was tacitly trying to turn the page and comfort itself, the news about Tsingshan Pharmaceutical came suddenly like a thunderclap!

Reuters:

【Breaking news! 】

[Huaxia Qingshan Pharmaceutical officially announced! 】

[After a year and a half, Qingshan Pharmaceutical's latest liver cirrhosis treatment drug, the 'liver cell regeneration activator', achieved a historic breakthrough, achieving the first clinical reversal of liver cirrhosis in human history! ]

The first clinical reversal of cirrhosis in human history!

Cirrhosis reversed!

As soon as the message was sent out, it immediately made it to the Twitter homepage!
Countless American netizens were stunned instantly!
"???F...uck!!"

"Cirrhosis! Reversal?!"

The shocking news reminded all American netizens of the previously wildly hyped "LivClearX". If Novartis' "LivClearX" for treating fatty liver disease was touted as a miracle drug, it was touted as the greatest contribution of modern medicine in the 21st century!
So!

What a big deal that we have achieved the reversal of liver cirrhosis for the first time in human history!
A miracle drug?!

The huge gap almost completely silenced the American Internet and netizens. Finally, two hours after the news came out, the top American medical journal, The New England Journal of Medicine, took the lead in publicly inviting Tsingshan Pharmaceutical to publish any information and clinical data on "hepatocyte activators" in its latest journal!
Actively invite contributions!
It was the New England Journal of Medicine, the top journal in the United States, that took the initiative to extend the invitation!
The American medical academic community is impressed by the achievements of Qingshan Pharmaceutical? !
Gradually, countless netizens on Twitter came to their senses, and more and more comments appeared about Tsingshan Pharmaceutical and hepatocyte activators.

"Can it really, really, really reverse cirrhosis of the liver?"

"Huaxia, Qingshan Pharmaceutical...Okay! I think I have to take off my tinted glasses. This Chinese pharmaceutical company is so strong, much stronger than I thought. It's so strong that I admire it!"

"Medicine should not have national boundaries. I admit that I used to have strong discrimination against Qingshan Pharmaceutical, but he conquered me. To be fair! He is the real light of medicine, the light of medicine for all mankind!"

"I think we have to reflect. From now on, we have to reflect on what went wrong with us."

“Yes, Qingshan Pharmaceutical is certainly worthy of our admiration, but are our pharmaceutical companies investing less and less? Is there something wrong with our market environment and system?”

"..."

A heated discussion was going on on the Internet. In the risk control office on the 17th floor of HSBC headquarters, Winston Davis stared at the news in shock, speechless.

He is not interested in China and even feels a little disgusted with it.

However, the Qingshan Pharmaceutical in front of him completely overturned his perception of Chinese pharmaceutical companies!
Even though Novartis’ “LivClearX” drug patent originated from them, unexpectedly, they actually developed a drug that is several times more powerful than “LivClearX” and can reverse liver cirrhosis!

After a moment, he opened the drawer, and inside was Novartis's domestically produced "LivClearX".

To be honest, he took the medicine for two months and the effect was quite good. Although fatty liver still existed, liver inflammation, blood indexes and even his mental state had indeed improved significantly!
This is thanks to this drug!
Thinking of this, he couldn't help but touch the right side of his abdomen, where the liver was.

After a full minute, a light suddenly flashed in his eyes!
"No, I have to take the original drug, this imported medicine from China!"

……

The news spread back home!

To be precise, the domestic network was the first to receive the historic news of Tsingshan Pharmaceutical’s official announcement of the “liver cell regeneration activator”!

The news came from a press release on Tsingshan Pharmaceutical's official website. Before it was even confirmed, the official media People's Daily was the first to reprint the news.

As soon as the news came out, it was immediately forwarded across the entire network. Within just ten minutes, it directly entered the top ten hot searches on Weibo, and then quickly swept through all the news and topped the list!

Not only on Weibo, the news about Qingshan Pharmaceutical quickly swept the Baidu popularity list and the Douyin popularity list. The first topic of all major apps was:
[For the first time in human history! Qingshan Pharmaceutical has achieved the first reversal of liver cirrhosis in human history! ]

The exciting news quickly spread throughout the entire Chinese Internet, and almost every netizen clicked on it to take a look!

You know, there are many hepatitis B patients in China, and there are tens of millions of people suffering from cirrhosis caused by hepatitis B!
More importantly, how many years have passed!

Chinese pharmaceutical companies finally have a strong competitor that can conquer the world!

"What is the light of humanity, what is the beacon of humanity! This is it! Qingshan Pharmaceutical is it!"

"It's so fucking cool, so awesome, @Qingshan Pharmaceutical, when Novartis' new drug 'LivClearX' came out, so many people in China were jealous of you, so many people laughed at you! What about now!

No one is optimistic about you, but you are the most competitive! "

"Yeah, why do I feel my eyes a little sore? After so many years, we finally have our own pharmaceutical company. Finally someone has made a difference! Really, you are so awesome. You really made us proud!"

"Those Americans were bragging about their 'LivClearX' being able to treat fatty liver disease, look at us, look at us! We can now reverse cirrhosis! Isn't that awesome!"

"Awesome! Qingshan Pharmaceutical is awesome! We used to envy them for having so many good pharmaceutical companies, but now it's finally their turn to envy us. Don't ask us who we have, as long as we have Qingshan Pharmaceutical!"

"Fuck, that's cool!"

……

The Internet was abuzz with discussion, with various media outlets reporting frantically on this historic achievement of Tsingshan Pharmaceutical. It was almost impossible for anyone browsing the Chinese Internet not to know about this news.

Do not,
To be precise, there is a high probability that you will see this news even when browsing the Internet.

In the Shanghai headquarters building of HSBC, George Lin looked at the news in front of him with some bitterness. Novartis' clarification announcement had dealt him a heavy blow, but he did not expect that just one month later, Tsingshan Pharmaceutical would deal him another heavy blow.

This is not the most important thing.

Last time he went on a business trip to the United States, although his aunt Wang Guilan did not ask him to help buy "LivClearX" on her behalf,
But as he breathed in the fresh American air and watched the massive amounts of publicity in the media, he thought of his immediate superior, David, the audit manager.

During the last physical examination, he noticed that David's ultrasound results showed fatty liver, so after thinking about it, he took the initiative to buy six bottles of "LivClearX" for David.

When the drug was first given to David, he was very happy. After all, David had also learned from abroad about this fatty liver treatment drug which has recently become very popular among the middle class.

but.

When Novartis clarified that "LivClearX" was derived from Tsingshan Pharmaceutical's patented technology, he vaguely felt that David seemed somewhat dissatisfied with him.

After all, he secretly looked at Twitter and saw that many people said that "LivClearX" was a castrated version and a semi-finished product of Tsingshan Pharmaceutical.

But now,
LivClearX is no longer just a castrated version. With the launch of Tsingshan Pharmaceutical's top-level "hepatocyte activator",
"LivClearX" will undoubtedly become a second-tier product, and its positioning is very awkward.

"Hey!"

Lin George sighed slightly, and at this moment, the phone on the desk suddenly rang.

He was startled and when he picked up the phone, it turned out to be his boss David.

"George, please come to my office right now."

"Okay, BOSS!"

After hanging up the phone, Lin George was very nervous. He quickly came to David's office, adjusted his breathing and whispered:

"Boss, I'm here. Please tell me what I need."

David glanced at George Lin and said:

"Nothing serious. Winston, the manager of the risk control department at HSBC's US headquarters, called me personally."

"He wants to buy some 'liver cell activator' from Qingshan Pharmaceutical. You are familiar with Qingshan Pharmaceutical, right? I'll leave this matter to you."

Lin George was suddenly stunned.

Manager Winston asked me to buy things for him?!
wrong,

Winston wants to purchase Qingshan Pharmaceutical's hepatocyte activator?

After a moment, he reacted:
"Boss, the drug from Qingshan Pharmaceutical has not yet been launched on the market. It is still in clinical trials... I don't know when it will be launched on the market."

David shook his head.
"Manager Winston just told me that he has learned about this drug in detail. It is about to complete the third phase of clinical trials and will be available on the market in about two months."

"Remember this matter, pay attention to it every day, and report to me immediately if you have any news!"

Pay attention to Tsingshan Pharmaceutical every day?

Lin George felt like the sky was falling.

"Is there a problem?"

"No...no."

David finally showed a smile.

Just when Lin George thought it was over, his immediate superior David suddenly spoke again:

"By the way, George, I only opened one bottle of Novartis' LivClearX that you gave me last time. You can take the remaining five bottles back."

“I’m a little uncomfortable with things made in the United States.”

"I heard that the liver protection effect of Qingshan Pharmaceutical's 'hepatocyte activator' is several times that of 'LivClearX'. When Qingshan Pharmaceutical's drug comes out, I want to try it."

Lin George's eyes suddenly became dull...

……

The news that Tsingshan Pharmaceutical's "hepatocyte activator" had achieved a historic breakthrough shocked the world.

Zhang Yang, who was in the middle of the storm, immediately received interview requests from many media outlets, including CCTV, but Zhang Yang declined them all.

At present, the "hepatocyte activator" has not officially completed the Phase III clinical trial, but its clinical data is sufficient to support its successful passing of the Phase III clinical trial and listing on the market.

Now he has to do:
First, go through the green approval channel of the "National Key Disease List" and start the pre-approval application for production approval.

Secondly, it is very important to determine the final retail price of the "hepatocyte activator".

He handed the first task to Liu Fei, who was in charge of the production project. With the cooperation of Lotus Pharmaceuticals, once the Phase III clinical trial was approved, the production approval would be obtained quickly and put into sales.

The second thing is pricing.

This time he did not act arbitrarily, but instead called together Ren Xiaomin, Wei Tian, ​​and several colleagues from the marketing department to discuss the final pricing of the "hepatocyte activator".

Zhang Yang and the entire Qingshan Pharmaceutical are positioning this drug for patients in the "compensated" and "decompensated" stages of liver cirrhosis.

Although the clinical data is not very sufficient, it has been confirmed that the "compensatory stage", or early cirrhosis, can begin to reverse after taking the drug for two months.

According to calculations and preliminary estimates, if the drug is taken continuously for about one year, patients with early-stage cirrhosis should be able to completely reverse the transition from cirrhosis to liver fibrosis.

After one year, the dosage can be gradually reduced from 4 200 mg tablets per day to 2 100 mg tablets per day.

Although there has been no obvious reversal in patients with advanced liver cirrhosis, the research and development team has also calculated that they should be able to reverse to the "compensatory stage" level after one year of taking the drug.

That is, mid-stage cirrhosis and early-stage cirrhosis.

Of course, since late-stage cirrhosis has caused large-scale hardening of the liver, it is impossible to fully recover again. It is very good to be able to restore a certain level of liver function.

Patients with advanced liver cirrhosis need to continue taking medication after one year, and there is currently no complete data on the specific subsequent medication cycle.

Of course, since the drug itself contains a large amount of liver cell regeneration and activating substances, it naturally has the effect of protecting and preserving the liver.

Moreover, it can be seen from Novartis' "LivClearX", which only contains 50% of the ingredients, that it is also effective in treating severe fatty liver. The complete "hepatocyte activator" will only be stronger and the effect will be more obvious.

After comprehensive consideration, the final price was set at 6500 yuan per bottle.

After determining their own retail price, Liu Weiguo, deputy director of the Purchasing Department of the Medical Insurance Bureau, who received the news, came to Qingshan Pharmaceutical in person.
Liu Weiguo and Zhang Yang are also old friends.

He was deeply moved when Zhang Yang took the initiative to reduce the price of the hepatitis B drug "Ekofovir" to 500 yuan per box.

It would be a lie to say I don't admire it.

"Mr. Zhang, nice to see you again. I'm really happy to see that you are in good health."

Zhang Yang smiled slightly. He was a little surprised by Liu Weiguo's active visit, but it was also reasonable.

"Director Liu, you are so proactive. We haven't even finished Phase III clinical trials yet and you came here. You're not so impatient."

"Haha."

Liu Weiguo smiled and shook his head, saying with emotion:
"Mr. Zhang, you may not know that many patients with liver cirrhosis across the country are looking forward to your drug being launched on the market as soon as possible."

“We have a burden on our shoulders, so we have to do something practical for the people, right?

Your drug is as scarce as the previous 'Ekofovir' and is urgently needed by the people. Naturally, we should deal with these issues before it goes on the market."

"Then the people's medication can at least be reimbursed for part of it."

Zhang Yang nodded.

Although there are many bad things in this country, there are still many pure people even in the darkest times.

Liu Weiguo should be counted as one of them.

"Okay, let's talk about the price."

"But... to be honest, we have already decided on the retail price."

"Well, please tell me first..."

This time, Liu Weiguo also knew the value of the "hepatocyte activator" and that it was an innovative drug. After a brief bargain, the final price for inclusion in the medical insurance was 500 yuan cheaper.

The price included in the medical insurance is 6000 yuan, and it is a Class B reimbursed drug.

Due to the high unit price, the state reimburses 35%, totaling 2100 yuan, and individuals bear 65%, totaling 3900 yuan.

After confirming everything, as the Phase III clinical trial of the "hepatocyte activator" was completed, Zhang Yang also revealed the price in advance on the official website.

Retail price: 6500 yuan.

Medical insurance price: 6000 yuan.

The individual bears 65%, which is 3900 yuan at his own expense.

Medical insurance covers 35% and reimburses 2100 yuan.

The news of pricing appeared on the Internet and quickly sparked a lot of heated discussion!
(End of this chapter)